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RISS 인기검색어
- 검색키워드
- 저자 : Tsu-Cheng Chiang (검색결과 9 건)
- 무료
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Economic Burden of High-Responding Inhibitors in Patients with Hemophilia A in Taiwan
Tsu-Chiang Tu,Shin-Nan Cheng,Jye-Daa Chen,Thau-Ming Cham,Mei-Ing Chung 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.2
Purpose: Hemophilia A (HA) is the most common X-linked inherited bleeding disorder. In some patients with HA, particularly those with severe HA, replacement therapy results in the production of high-responding clotting factor VIII inhibitors. The economic burden of this complication is the highest reported for a chronic disease. Our aim was to investigate the direct medical expenditure burden of high-responding inhibitors in patients with HA. Materials and Methods: A retrospective study was conducted using the National Health Insurance Research Database,utilizing data covering the period of 2004-2007. Results: In total, 638 males with HA¸ including 37 patients with high-responding inhibitors were evaluated. Over 99% of the annual median medical expenditure was attributable to the cost of clotting factor concentrates (CFCs) in patients with high-responding inhibitors. The annual median expenditure related to CFCs of the total medical care and outpatient care were US$170611 and US$141982, respectively, and were 4.6- and 4.3-fold higher in these patients during the study period, respectively. In patients with high-responding inhibitors, the median hospitalization expenditure and daily hospitalization cost with or without surgical procedures were 3.0- and 2.4-fold higher, respectively, and 4.3 and 5.6-fold higher, respectively. Conclusion: Our data reveal higher medical expenditures burden for patients with HA and high-responding inhibitors in Taiwan. Future research is encouraged to evaluate the impact of this burden on patient quality of life.
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Piecewise exact solution for analysis of base-isolated structures under earthquakes
C. S. Tsai,Tsu-Cheng Chiang,Bo-Jen Chen,Kuei-Chi Chen 국제구조공학회 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.19 No.4
Base isolation technologies have been proven to be very efficient in protecting structures from seismic hazards during experimental and theoretical studies. In recent years, there have been more and more engineering applications using base isolators to upgrade the seismic resistibility of structures. Optimum design of the base isolator can lessen the undesirable seismic hazard with the most efficiency. Hence, tracing the nonlinear behavior of the base isolator with good accuracy is important in the engineering profession. In order to predict the nonlinear behavior of base isolated structures precisely, hundreds even thousands of degrees-of-freedom and iterative algorithm are required for nonlinear time history analysis. In view of this, a simple and feasible exact formulation without any iteration has been proposed in this study to calculate the seismic responses of structures with base isolators. Comparison between the experimental results from shaking table tests conducted at National Center for Research on Earthquake Engineering in Taiwan and the analytical results show that the proposed method can accurately simulate the seismic behavior of base isolated structures with elastomeric bearings. Furthermore, it is also shown that the proposed method can predict the nonlinear behavior of the VCFPS isolated structure with accuracy as compared to that from the nonlinear finite element program. Therefore, the proposed concept can be used as a simple and practical tool for engineering professions for designing the elastomeric bearing as well as sliding bearing.
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Piecewise exact solution for analysis of base-isolated structures under earthquakes
Tsai, C.S.,Chiang, Tsu-Cheng,Chen, Bo-Jen,Chen, Kuei-Chi Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.19 No.4
Base isolation technologies have been proven to be very efficient in protecting structures from seismic hazards during experimental and theoretical studies. In recent years, there have been more and more engineering applications using base isolators to upgrade the seismic resistibility of structures. Optimum design of the base isolator can lessen the undesirable seismic hazard with the most efficiency. Hence, tracing the nonlinear behavior of the base isolator with good accuracy is important in the engineering profession. In order to predict the nonlinear behavior of base isolated structures precisely, hundreds even thousands of degrees-of-freedom and iterative algorithm are required for nonlinear time history analysis. In view of this, a simple and feasible exact formulation without any iteration has been proposed in this study to calculate the seismic responses of structures with base isolators. Comparison between the experimental results from shaking table tests conducted at National Center for Research on Earthquake Engineering in Taiwan and the analytical results show that the proposed method can accurately simulate the seismic behavior of base isolated structures with elastomeric bearings. Furthermore, it is also shown that the proposed method can predict the nonlinear behavior of the VCFPS isolated structure with accuracy as compared to that from the nonlinear finite element program. Therefore, the proposed concept can be used as a simple and practical tool for engineering professions for designing the elastomeric bearing as well as sliding bearing.
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Tsai, C.S.,Lin, Yung-Chang,Chen, Wen-Shin,Chiang, Tsu-Cheng,Chen, Bo-Jen Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.35 No.2
Recently, earthquake proof technology has been widely applied to both new and existing structures and bridges. The analysis of bridge systems equipped with structural control devices, which possess large degrees of freedom and nonlinear characteristics, is a result in time-consuming task. Therefore, a piecewise exact solution is proposed in this study to simplify the seismic mitigation analysis process for bridge systems equipped with sliding-type isolators. In this study, the simplified system having two degrees of freedom, to reasonably represent the large number of degrees of freedom of a bridge, and is modeled to obtain a piecewise exact solution for system responses during earthquakes. Simultaneously, we used the nonlinear finite element computer program to analyze the bridge responses and verify the accuracy of the proposed piecewise exact solution for bridge systems equipped with sliding-type isolators. The conclusions derived by comparing the results obtained from the piecewise exact solution and nonlinear finite element analysis reveal that the proposed solution not only simplifies the calculation process but also provides highly accurate seismic responses of isolated bridges under earthquakes.
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Seismic behavior of structures isolated with a hybrid system of rubber bearings
Chen, Bo-Jen,Tsai, C.S.,Chung, L.L.,Chiang, Tsu-Cheng Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.22 No.6
The enlargement of interest in base isolators as an earthquake-proof design strategy has dramatically accelerated experimental studies of elastomeric bearings worldwide. In this paper, a new base isolator concept that is a hybrid system of rubber bearings is proposed. Uniaxial, biaxial, and triaxial shaking table tests are also performed to study the seismic behavior of a 0.4-scale three-story isolated steel structure in the National Center for Research on Earthquake Engineering in Taiwan. Experimental results demonstrate that structures with a hybrid system of rubber bearings composed of stirruped rubber bearings and laminated rubber bearings can actually decrease the seismic responses of the superstructure. It has been proved through the shaking table tests that the proposed hybrid system of rubber bearings is a very promising tool to enhance the seismic resistance of structures. Moreover, it is demonstrated that the proposed analytical model in this paper can predict the mechanical behavior of the hybrid system of rubber bearings and seismic responses of the base-isolated structures.
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C.S. Tsai,Yung-Chang Lin,Wen-Shin Chen,Tsu-Cheng Chiang,Bo-Jen Chen 국제구조공학회 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.35 No.2
Recently, earthquake proof technology has been widely applied to both new and existing structures and bridges. The analysis of bridge systems equipped with structural control devices, which possess large degrees of freedom and nonlinear characteristics, is a result in time-consuming task. Therefore, a piecewise exact solution is proposed in this study to simplify the seismic mitigation analysis process for bridge systems equipped with sliding-type isolators. In this study, the simplified system having two degrees of freedom, to reasonably represent the large number of degrees of freedom of a bridge, and is modeled to obtain a piecewise exact solution for system responses during earthquakes. Simultaneously, we used the nonlinear finite element computer program to analyze he bridge responses and verify the accuracy of the proposed piecewise exact solution for bridge systems equipped with sliding-type isolators. The conclusions derived by comparing the results obtained from the piecewise exact solution and nonlinear finite element analysis reveal that the proposed solution not only simplifies the calculation process but also provides highly accurate seismic responses of isolated bridges under earthquakes.
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