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- 저자 : Toshiyuki Kanno (검색결과 2 건)
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Toshiyuki Kanno,Hideo Matsui,Yoshika Akizawa,Hirokazu Usui,Makio Shozu 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.6
Objective: Highly effective chemotherapy for patients with low-risk gestational trophoblastic neoplasia (GTN) is associated with almost a 100% cure rate. However, 20%–30% of patients treated with chemotherapy need to change their regimens due to severe adverse events (SAEs) or drug resistance. We examined the treatment outcomes of second-line chemotherapy for patients with low-risk GTN. Methods: Between 1980 and 2015, 281 patients with low-risk GTN were treated. Of these 281 patients, 178 patients were primarily treated with 5-day intramuscular methotrexate (MTX; n=114) or 5-day drip infusion etoposide (ETP; n=64). We examined the remission rates, the drug change rates, and the outcomes of second-line chemotherapy. Results: The primary remission rates and drug resistant rates of 5-day ETP were significantly higher (p<0.001) and significantly lower (p=0.002) than those of 5-day MTX, respectively. Forty-seven patients (26.4%) required a change in their chemotherapy regimen due to the SAEs (n=16) and drug resistance (n=31), respectively. Of these 47 patients failed the first-line regimen, 39 patients (39/47, 82.9%) were re-treated with single-agent chemotherapy, and 35 patients (35/39, 89.7%) achieved remission. Four patients failed second-line, single-agent chemotherapy and eight patients (17.0%) who failed first-line regimens were treated with combined or multi-agent chemotherapy and achieved remission. Conclusions: Patients with low-risk GTN were usually treated with single-agent chemotherapy, while 20%–30% patients had to change their chemotherapy regimen due to SAEs or drug resistance. The second-line regimens of single-agent chemotherapy were effective; however, there were several patients who needed multiple agents and combined chemotherapy to achieve remission.
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Isaku Kanno,Hidetoshi Kotera,Kiyotaka Wasa,Ryouichi Takayama,Takeshi Kamada,Toshiyuki Matsunaga 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.IV
Compositional dependence of crystallographic structure of the epitaxial Pb(Zr,Ti)O3 (PZT) lms was investigated. The c-axis oriented PZT lms with Zr/Ti ratio ranging from 10/90 to 70/30 were epitaxially grown on (100)Pt/(100)MgO substrates using rf-sputtering. Four-circle x-ray diraction measurements revealed that the PZT lms exhibited anomalous crystalline structure which was considerably dierent from the phase diagram of bulk PZT. In particular, the PZT lms showed tetragonal structure even with the Zr/Ti composition above 53/47 and rhombohedral phase could not be identied even for the PZT lms of 70/30. The lattice constants of the PZT lms were independent of the lm thickness. The sputtering process accompanies non-thermal equilibrium reactions with the bombardment of the energetic sputtered particles to the growing lms and might induce isotropic internal stress across the lms. The anomalous crystalline characteristics are attributed to the sputter-induced stress of the PZT lms.
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