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( Feng Wang ),( Xiaodong Tian ),( Chunxin Yang ),( Yinmo Yang ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Cancer stem cells (CSCs) indicate multipotent cells exhibiting self-renewal capacity, multilineage differentiation ability and high carcinogenesis, and are closely related to tumor growth, metastasis, recurrence and chemoresistance. As tumorigenic drivers, CSCs should be effectively targeted to achieve long-lasting therapeutic responses. This study aimed to explore the mechanism of the novel Tripterygium wilfordii Hook F (TWHF) extract Demethylzeylasteral (ZST93) on inhibiting human pancreatic CSCs. Methods: Serum-free floating culture system was used to isolate CSCs. CCK-8 assay was used to evaluate the chemosensitivity. Apoptosis was evaluated by flow cytometry. Autophagy level was evaluated by transmission electron microscopy and immunofluorescence. The activity levels of caspase-3, ERK1/2 and Akt/mTOR pathways were determined by Western blot. Results: Tumorspheres had differentiation ability and stem celllike properties. ZST93 could inhibit the number and diameter of tumorspheres. ZST93 could induce apoptotic cell death in pancreatic CSCs at high concentrations, but not at low concentrations. The apoptosis induced by ZST93 was associated with the significant up-regulation of active caspase-3 expression. ZST93 could induce autophagic cell death in pancreatic CSCs at low concentrations, but not at high concentrations. The autophagy induced by ZST93 was associated with the significant up-regulation of p-ERK1/2 and down-regulation of p-Akt and p-mTOR expression. Conclusions: We revealed that ZST93 inhibits pancreatic CSCs through two different mechanisms, low concentrations of ZST93 could induce autophagic cell death by activating ERK1/2 pathway and inhibiting Akt/mTOR pathway, and high concentrations of ZST93 could induce caspase-3-dependent apoptotic cell death. ZST93 is a potential therapeutic agent for developing novel therapeutic strategies in human pancreatic cancer.
Yan Rui,Wang Kai,Tian Xiaodong,Li Xiao,Yang Tao,Xu Xiaotong,He Yiting,Lei Shiwen,Song Yan 한국탄소학회 2020 Carbon Letters Vol.30 No.3
Heteroatoms in situ-doped hierarchical porous hollow-activated carbons (HPHACs) have been prepared innovatively by pyrolyzation of setaria viridis combined with alkaline activation for the frst time. The micro-morphology, pore structure, chemical compositions, and electrochemical properties are researched in detail. The obtained HPHACs are served as outstand�ing electrode materials in electrochemical energy storage ascribe to the particular hierarchical porous and hollow structure, and the precursor setaria viridis is advantage of eco-friendly as well as cost-efective. Electrochemical measurement results of the HPHACs electrodes exhibit not only high specifc capacitance of 350 F g−1 at 0.2 A g−1, and impressive surface specifc capacitance (Cs) of 49.9 μF cm−2, but also substantial rate capability of 68% retention (238 F g−1 at 10 A g−1) and good cycle stability with 99% retention over 5000 cycles at 5 A g−1 in 6 M KOH. Besides, the symmetrical supercapacitor device based on the HPHACs electrodes exhibits excellent energy density of 49.5 Wh kg−1 at power density of 175 W kg−1 , but still maintains favorable energy density of 32.0 Wh kg−1 at current density of 1 A g−1 in 1-ethy-3-methylimidazolium tetrafuoroborate (EMIMBF4) ionic liquid electrolyte, and the excellent cycle stability behaviour shows the nearly 97% ratio capacitance retention of the initial capacitance after 10,000 cycles at current density of 2 A g−1. Overall, the results indicate that HPHACs derived from setaria viridis have appealing electrochemical performances thus are promising electrode materi�als for supercapacitor devices and large-scale applications.
Haozhe Liu,Xinxin Tian,Huan Liu,Xiaodong Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
Aiming at enhancing the detection of phenolic contaminants in high-temperature environments, wedeveloped a thermoregulatory electrochemical biosensor based on the tyrosinase-immobilized electroactivephase-change microcapsules. The microcapsules were fabricated by engulfing n-eicosane as a phasechangematerial core in a TiO2 shell, followed by depositing with an electroactive hybrid layer comprisingthe polypyrrole matrix and tyrosinase-immobilized Fe3O4 nanoparticles. The resultant microcapsulesshow a well-defined core–shell microstructure and a regular spherical morphology, together with thedesired chemical compositions and structures. Acting as a biosensing electrode material, the microcapsulesexhibit a high latent heat capacity of around 150 J/g to implement microenvironmental temperatureregulation for the biosensor through reversible phase transitions of their n-eicosane core. Thisenables the developed biosensor to obtain a higher enzyme activity and more sensitive biosensing performanceat high assay temperatures when compared to conventional tyrosinase biosensors, resultingin a high sensitivity of 0.102 (lAL)/lmol and a lower detection limit of 3.409 lmol/L for catechol detection. Based on a unique integration of phase-change microcapsules and immobilized tyrosinase in theworking electrode, the electrochemical biosensor developed in this study has found a practical applicationfor high-sensitive reorganization and high-accurate determination of phenolic contaminants inindustrial wastewaters over a wide working temperature range.