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- 저자 : Thomas L. Rothstein (검색결과 2 건)
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B세포의 증식에 있어 B-1 임파구와 B-2 임파구의 차이점에 대한 연구
여승근,조중생,박동춘,Thomas L. Rothstein 대한면역학회 2004 Immune Network Vol.4 No.3
Background: B-1 cells differ from conventional B-2 cells both phenotypically and functionally. The aim of this study was to investigate the difference between peritoneal B-1 cells and splenic B-2 cells in proliferation. Methods: We obtained sorted B-1 cells from peritoneal fluid and B-2 cells from spleens of mice. During the culture of these cells, immunoglobulin secreted into the culture supernatants was evaluated by enzyme- linked immunosorbent assay. Entering of S phase in response to LPS-stimuli was measured by proliferative assay. Results: Spontaneous Immunoglobulin M production occurred in peritoneal B-1 cells but not in splenic B-2 cells. LPS stimulated peritoneal B-1 cells secreted IgM at day 1, but splenic B-2 cells at day 2. In thymidine incorporation, peritoneal B-1 cells entered actively S phase after 24hours LPS-stimulation but splenic B-2 cells entered actively S phase after 48 hours. Conclusion: IgM secretion and S phase entering occurred early in peritoneal B-1 cells compared to splenic B-2 cells. (Immune Network 2004;4(3):155-160)
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Characteristic features of B cells in murine cervical lymph nodes
YEO, SEUNG GEUN,TUMANG, JOSEPH R.,ROTHSTEIN, THOMAS L. 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-
Conclusion. B cells in cervical lymph nodes correspond to typical conventional B cells (B-2). Objective. The special status of cervical lymph nodes in relation to the oropharynx, and the need to maintain the integrity of the oropharnygeal mucosal barrier, suggest the possibility that cervical lymph node B cells located in the oropharynx may behave differently from B cells located elsewhere. In this study we examined the symmetry or lack thereof between cervical lymph node B cells and other B-cell subsets. Material and methods. We isolated B cells from murine cervical lymph node tissue and evaluated them in vitro according to several criteria. Results. We found that cervical lymph node B cells expressed typical B-cell phenotypic markers and proliferated normally in response to mitogenic stimulation. They did not spontaneously secrete immunoglobulin and, in keeping with this, did not express elevated levels of either CD138 (Syndecan-1), a marker for plasma cells, or BLIMP-1, a putative master regulator of B-cell differentiation.
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