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Development of simple HPLC-UV method for discrimination of Adenophorae Radix
Vu, Thi Phuong Duyen,Kim, Kyung Tae,Pham, Yen,Bao, Haiying,Kang, Jong Seong The Korean Society of Analytical Science 2017 분석과학 Vol.30 No.2
Adenophorae Radix (AR) is a frequently used medicinal herb; because of its popularity, products containing similar herbal products are often sold as substitutes, especially if their morphology is similar. However, any analytical method to identify AR based on quantitative analysis is not registered in Korea, Japan and China Pharmacopoeias. This study developed a simple HPLC method to discriminate between authentic AR and substitutes. Linoleic acid was used as a marker compound of AR. Our optimized HPLC-UV conditions included a mobile phase of 90 % acetonitrile under isocratic condition, and a flow rate of 1.0 mL/min at room temperature. Detection wavelength was set at 205 nm. Linoleic acid was detected at 13.5 minutes for a total analysis time of 20 minutes. The standard herb of AR contained 0.025 % of linoleic acid, while four authentic AR samples and eight substitutes contained 0.040~0.071 % and 0.004~0.014 %, respectively. Comparison of the linoleic acid concentrations of the sample types to reference AR showed that among 12 samples, only the four samples were authentic. Thus, our HPLC-UV method, along with our suggested content criterion for linoleic acid concentration, can be used for the quick and accurate determination whether the herbal products are authentic AR or substitute.
Nguyen, Thi Minh Nguyet,Lomunova, Maria,Vu, Thi Phuong Duyen,Le, Ba Vinh,Kim, Young Ho,Kang, Jong Seong,Hwang, Inkyu Elsevier 2018 Journal of Ethnopharmacology Vol.211 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>As documented in a Vietnamese traditional medical encyclopedia, <I>Syzygium formosum</I> (Wall.) Masam leaves have been routinely used among indigenous Vietnamese people for treatment of various allergy-like symptoms including dermatitis and rhinitis.</P> <P><B>Aim of the study</B></P> <P>Anti-allergic activity of <I>S. formosum</I> leaves was examined with a mouse model of chicken ovalbumin (cOVA)-induced food allergy, and mechanisms underlying the anti-allergic effect were explored.</P> <P><B>Material and methods</B></P> <P>BALB/c mice were administered i.p. cOVA (20μg) plus alum (2mg) twice on day 0 and 14 for sensitization (immunization). Two weeks after the second immunization, the mice were administered cOVA (50mg) p.o. 5 times every 3 days to induce food allergy symptoms (i.e., anaphylaxis, diarrhea, and drop in the body temperature). Ethanol extract of dried leaves of <I>S. formosum</I> (80mg/kg or 200mg/kg body weight) was administered p.o. daily during the induction (challenge) period.</P> <P><B>Results</B></P> <P>Treatment with the <I>S. formosum</I> leaves ethanol extract ameliorated the allergic symptoms to a significant extent and in a dose-dependent manner. The treatment also resulted in a significant improvement in the inflammatory lesion in the small intestine and reduction in the numbers of mast cells and eosinophils recruited to the lesion. The treatment also brought about a significant reduction in the levels of Th2 cytokines produced by the mesenteric lymph node cells cultured ex vivo with cOVA. The passive anaphylaxis experiment also showed that the extract treatment impaired the mast cell function.</P> <P><B>Conclusion</B></P> <P>Our study provides a scientific basis for the traditional (indigenous) use of the <I>S. formosum</I> leaves extract for the treatment of various allergy symptoms in Vietnam. In addition, the results show that the extract has activities to suppress antigen-specific Th2 T cell immune responses and the mast cell function, which are directly related with its anti-allergic effect.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>