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Influence of alcohol consumption on blood coagulation in ROTEM: an in-vivo study
Eismann Hendrik,Sieg Lion,Ahmed Hala,Teske Joerg,Behrendt Patrick,Friedrich Lars,Schumacher Carsten,Johanning Kai 대한마취통증의학회 2020 Korean Journal of Anesthesiology Vol.73 No.4
Background: Twenty-five to 85% of trauma patients are under the influence of alcohol in addition to experiencing injury-related coagulation impairment. Viscoelastic point-of-care tests (thrombelastography [TEG], rotational thromboelastometry [ROTEM]) are popular tools for rapid hemostasis assessment and therapeutic decision-making in this and other settings. While alcohol affects these tests in-vitro, their specific effects in-vivo are unclear. Therefore, we evaluated the effects of alcohol ingestion on ROTEM parameters. Methods: Twenty volunteers provided informed consent to drinking red wine, whisk(e)y, or vodka to a target blood alcohol concentration of 1‰ within one hour, calculated with the Widmark formula. Blood samples were collected before drinking, at a breath alcohol concentration of 0.5‰, and at 1.0‰, but no later than one hour. After each blood collection, ExTEM and FibTEM tests were performed directly “at the bedside.” Results: All participants had a blood alcohol concentration (BAC) of 0.00‰ at the beginning. The mean BACs at the second and third collection were 0.48 and 0.76‰, respectively. There were no significant differences in the ExTEM parameters. FibTEM measurements showed a significant difference at the A10 value (13.0 vs. 14.0 mm, P = 0.014) and a trend at the maximum amplitude (maximum clot firmness 13.7 vs. 16.2 mm, P = 0.075). We saw no significant differences in fibrinolysis parameters and no hyperfibrinolysis in our ROTEM measurements. Conclusions: Ethanol ingestion can impair early fibrin polymerization. These results might be of special relevance in trauma and support routine application of ROTEM/TEG in such cases.
ELECTROCHEMICAL PROCESSING OF USED NUCLEAR FUEL
Goff, K.M.,Wass, J.C.,Marsden, K.C.,Teske, G.M. Korean Nuclear Society 2011 Nuclear Engineering and Technology Vol.43 No.4
As part of the Department of Energy's Fuel Cycle Research and Development Program an electrochemical technology employing molten salts is being developed for recycle of metallic fast reactor fuel and treatment of light water reactor oxide fuel to produce a feed for fast reactors. This technology has been deployed for treatment of used fuel from the Experimental Breeder Reactor II (EBR-II) in the Fuel Conditioning Facility, located at the Materials and Fuel Complex of Idaho National Laboratory. This process is based on dry (non-aqueous) technologies that have been developed and demonstrated since the 1960s. These technologies offer potential advantages compared to traditional aqueous separations including: compactness, resistance to radiation effects, criticality control benefits, compatibility with advanced fuel types, and ability to produce low purity products. This paper will summarize the status of electrochemical development and demonstration activities with used nuclear fuel, including preparation of associated high-level waste forms.
ELECTROCHEMICAL PROCESSING OF USED NUCLEAR FUEL
K. M. GOFF,J. C. WASS,K. C. MARSDEN,G. M. TESKE 한국원자력학회 2011 Nuclear Engineering and Technology Vol.43 No.4
As part of the Department of Energy’s Fuel Cycle Research and Development Program an electrochemical technology employing molten salts is being developed for recycle of metallic fast reactor fuel and treatment of light water reactor oxide fuel to produce a feed for fast reactors. This technology has been deployed for treatment of used fuel from the Experimental Breeder Reactor II (EBR-II) in the Fuel Conditioning Facility, located at the Materials and Fuel Complex of Idaho National Laboratory. This process is based on dry (non-aqueous) technologies that have been developed and demonstrated since the 1960s. These technologies offer potential advantages compared to traditional aqueous separations including: compactness,resistance to radiation effects, criticality control benefits, compatibility with advanced fuel types, and ability to produce low purity products. This paper will summarize the status of electrochemical development and demonstration activities with used nuclear fuel, including preparation of associated high-level waste forms.
Hoetzenecker, Wolfram,Echtenacher, Bernd,Guenova, Emmanuella,Hoetzenecker, Konrad,Woelbing, Florian,Br체ck, J체rgen,Teske, Anna,Valtcheva, Nadejda,Fuchs, Kerstin,Kneilling, Manfred,Park, Ji-Hyeon,Kim, K Nature Publishing Group, a division of Macmillan P 2012 Nature medicine Vol.18 No.1
Sepsis, sepsis-induced hyperinflammation and subsequent sepsis-associated immunosuppression (SAIS) are important causes of death. Here we show in humans that the loss of the major reactive oxygen species (ROS) scavenger, glutathione (GSH), during SAIS directly correlates with an increase in the expression of activating transcription factor 3 (ATF3). In endotoxin-stimulated monocytes, ROS stress strongly superinduced NF-E2??related factor 2 (NRF2)??dependent ATF3. In vivo, this ROS-mediated superinduction of ATF3 protected against endotoxic shock by inhibiting innate cytokines, as Atf3<SUP>??/??</SUP> mice remained susceptible to endotoxic shock even under conditions of ROS stress. Although it protected against endotoxic shock, this ROS-mediated superinduction of ATF3 caused high susceptibility to bacterial and fungal infections through the suppression of interleukin 6 (IL-6). As a result, Atf3<SUP>??/??</SUP> mice were protected against bacterial and fungal infections, even under conditions of ROS stress, whereas Atf3<SUP>??/??</SUP>Il6<SUP>??/??</SUP> mice were highly susceptible to these infections. Moreover, in a model of SAIS, secondary infections caused considerably less mortality in Atf3<SUP>??/??</SUP> mice than in wild-type mice, indicating that ROS-induced ATF3 crucially determines susceptibility to secondary infections during SAIS.
Estu Rudiktyo,Amiliana M Soesanto,Maarten J Cramer,Emir Yonas,Arco J Teske,Bambang B Siswanto,Pieter A Doevendans 한국심초음파학회 2023 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.31 No.4
BACKGROUND: Assessment of left ventricular (LV) function plays a pivotal role in the management of patients with valvular heart disease, including those caused by rheumatic heart disease. Noninvasive LV pressure-strain loop analysis is emerging as a new echocardiographic method to evaluate global LV systolic function, integrating longitudinal strain by speckle-tracking analysis and noninvasively measured blood pressure to estimate myocardial work. The aim of this study was to characterize global LV myocardial work efficiency in patients with severe rheumatic mitral stenosis (MS) with preserved ejection fraction (EF). METHODS: We retrospectively included adult patients with severe rheumatic MS with preserved EF (> 50%) and sinus rhythm. Healthy individuals without structural heart disease were included as a control group. Global LV myocardial work efficiency was estimated with a proprietary algorithm from speckle-tracking strain analyses, as well as noninvasive blood pressure measurements. RESULTS: A total of 45 individuals with isolated severe rheumatic MS with sinus rhythm and 45 healthy individuals were included. In healthy individuals without structural heart disease, the mean global LV myocardial work efficiency was 96% (standard deviation [SD], 2), Compared with healthy individuals, median global LV myocardial work efficiency was significantly worse in MS patients (89%; SD, 4; p < 0.001) although the LVEF was similar. CONCLUSIONS: Individuals with isolated severe rheumatic MS and preserved EF, had global LV myocardial work efficiencies lower than normal controls.