Inhibition of MicroRNA-92a Improved Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats via Suppressing Oxidative Stress and Endothelial Dysfunction

Tang Zhe,Song Jingyu,Yu Zhe,Cui Kai,Ruan Yajun,Liu Yang,Wang Tao,Wang Shaogang,Liu Jihong,Yang Jun 대한남성과학회 2023 The World Journal of Men's Health Vol.41 No.1

Purpose: To determine whether microRNA could be a therapy target of erectile dysfunction (ED) and the underlying mecha-nisms. Materials and Methods: Eight-week-old fasting male SD rats were intraperitoneally injected with streptozotocin to construct diabetic rat models. Diabetic ED rats were treated with miRNA-92a inhibitor. The cavernous nerves were electrically stimu-lated to measure the intracavernous pressure and mean arterial pressure of rats in each group. After the detection, the penile cavernous tissues are properly stored for subsequent experiments. Rat aortic endothelial cells were used in in vitro studies. Results: The expression of miR-92a was significantly increased in the corpus cavernosum of Streptozocin (STZ)-induced di- abetic rats and injection of miR-92a antagomir into the corpus cavernosum of diabetic rats significantly increased eNOS/NO/ cGMP signaling pathway activities, cavernous endothelial cell proliferation, endothelial cell-cell junction protein expression and decreased the levels of oxidative stress. These changes restored erectile function in STZ-induced diabetic rats. Moreover, in vitro study demonstrated that the miR-92a expression increased significantly in endothelial cells treated with high glucose, inhibiting AMPK/eNOS and AMPK/Nrf2/HO-1 signaling pathways in rat aortic endothelial cells via targeting Prkaa2, causing endothelial dysfunction and overactive oxidative stress, miR-92a inhibitor can improve the above parameters. Conclusions: miRNA-92a inhibitor could exert an inhibition role on oxidative stress and endothelial dysfunction to improve diabetic ED effectively.

이익조정과 기업가치의 관계에서 조세회피의 매개효과 검증

당옥철(Tang, Yu-zhe),주자운(Zhou, Zi-yun),양규혁(Yang, Kyu-heak) 전북대학교 산업경제연구소 2021 아태경상저널 Vol.13 No.1

본 연구의 목적은 이익조정이 기업가치에 미치는 영향을 분석하고 더불어 이익조정과 기업가치 사이에서 조세회피 행위의 매개역할을 검증하는 것이다. 실증분석을 위하여 2013년부터 2018년까지 국내 코스피와 코스닥 시장에 상장되어 있는 12월 결산인 비금융업 기업을 표본으로 이용하였다. 이익조정은 수정 Jones 모형 (Dechow et al., 1995)으로 측정하였고, 조세회피 행위에 대한 측정치는 Desai and Dharmapala (2006)의 재량적 BTD로, 기업가치는 Tobin"s Q로 측정하였다. 연구결과는 다음과 같다. 첫째, 이익조정이 기업가치에 양(+)의 영향을 미치는 것으로 나타났다. 이는 이익조정을 수행하는 기업의 이익정보가 기업의 건전한 경영상태와 이익의 지속성 및 성장성을 시장에 시그널링하여 기업가치에 긍정적인 영향을 미치고 있음을 의미한다. 둘째, 이익조정과 기업가치 사이에서 조세회피는 매개역할을 하는 것으로 나타났다. 따라서 이익조정은 기업가치에 직접 효과를 가질 뿐만 아니라 조세회피 행위의 감소를 통하여 기업가치를 증가시키는 간접 효과도 가지는 것으로 밝혀졌다. 본 연구는 이익조정과 기업가치 간의 관계를 검토하면서 조세회피를 이익조정이 기업가치에 영향을 미치는 과정 중의 매개변수로 간주하며 조세회피의 매개역할을 검증하였다는 데 그 의의가 있다. 본 연구의 결과는 자본시장에서 이익조정에 대한 정보를 이용할 때 조세회피 요인을 같이 고려할 필요가 있음을 시사한다. The purpose of this study is to analyze the effect of earnings management on corporate value and to verify the mediating effect of tax avoidance between earnings management and corporate value. For the empirical analysis, non-financial companies listed on the Korean KOSPI and KOSDAQ markets from 2013 to 2018 were used as a sample. The earnings management was measured by the Modified Jones model(Dechow et al., 1995), the tax avoidance behavior was measured by the discretionary BTD of Desai and Dharmapala (2006), and the firm value was measured by Tobin"s Q. The research results are as follows. First, it was found that the earnings management had a positive effect on firm values. This means that the earnings information of the company performing the earnings management has a positive effect on the firm value because it signals the company"s sound management status and profit sustainability and growth to the market. Second, it was found that tax avoidance had a mediating effect between earnings management and firm value. Therefore, it was found that earnings management not only has a direct effect on firm value, but also has an indirect effect of increasing firm value through reduction of tax avoidance activities. Unlike previous studies, this study is meaningful in that it examines the relationship between earnings management and firm value and at the same time verifies whether tax avoidance has a mediation effect between these two variables. The results of this study suggest that it is necessary to consider tax avoidance factors when using information on earnings management in the capital market.

Coffin-Siris syndrome in two chinese patients with novel pathogenic variants of ARID1A and SMARCA4

Liu Mingjie,Wan Linlin,Wang Chunrong,Yuan Hongyu,Peng Yun,Wan Na,Tang Zhichao,Yuan Xinrong,Chen Daji,Long Zhe,Shi Yuting,Qiu Rong,Tang Beisha,Tang Beisha,Chen Zhao 한국유전학회 2022 Genes & Genomics Vol.44 No.9

Background: Coffin-Siris syndrome (CSS) is a rare congenital syndrome characterized by developmental delay, intellectual disability, microcephaly, coarse face and hypoplastic nail of the fifth digits. Heterozygous variants of different BAF complex-related genes were reported to cause CSS, including ARID1A and SMARCA4. So far, no CSS patients with ARID1A and SMARCA4 variants have been reported in China. Objective: The aim of the current study was to identify the causes of two Chinese patients with congenital growth deficiency and intellectual disability. Methods: Genomic DNA was extracted from the peripheral venous blood of patients and their family members. Genetic analysis included whole-exome and Sanger sequencing. Pathogenicity assessments of variants were performed according to the guideline of the American College of Medical Genetics and Genomics. The phenotypic characteristics of all CSS subtypes were summarized through literature review. Results: We identified two Chinese CSS patients carrying novel variants of ARID1A and SMARCA4 respectively. The cases presented most core symptoms of CSS except for the digits involvement. Additionally, we performed a review of the phenotypic characteristics in CSS, highlighting phenotypic varieties and related potential causes. Conclusions: We reported the first Chinese CSS2 and CSS4 patients with novel variants of ARID1A and SMARCA4. Our study expanded the genetic and phenotypic spectrum of CSS, providing a comprehensive overview of genotype-phenotype correlations of CSS.

APPLICATIONS OF CALCIUM PHOSPHATE NANOPARTICLES IN POROUS HARD TISSUE ENGINEERING SCAFFOLDS

ZHE WANG,ZHURONG TANG,FANGZHU QING,YOULIANG HONG,XINGDONG ZHANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.4

To repair bone defects, an important approach is to fabricate tissue engineering sca®olds as substitutions to replace auto-/allologous bones. Currently, processing a biomaterial into threedimensional porous sca®olds and incorporating the calcium phosphate (Ca?P) nanoparticles into sca®olds pro¯le two main characteristics of bone tissue engineering sca®olds. Based on this fact, in this paper we describe the design principles of the Ca?P nanoparticle-based and porous bone tissue engineering sca®olds. Then we summarize a variety of the Ca?P nanoparticle-based sca®olds, including discussion of the integration of the Ca?P nanoparticles with ceramics and polymers, followed by introduction of safety of the Ca?P nanoparticles in scaffolds.

Association of Visit-to-Visit Variability of Blood Pressure with Cardiovascular Disease among Type 2 Diabetes Mellitus Patients: A Cohort Study

Zhe-Bin Yu,Die Li,Xue-Yu Chen,Pei-Wen Zheng,Hong-Bo Lin,Meng-Ling Tang,Ming-Juan Jin,Jian-Bing Wang,Kun Chen 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.3

Background: Increasing evidence has shown that visit-to-visit variability (VVV) of blood pressure (BP) is associated with an increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate the impact of VVV of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the risk of CVD among patients with type 2 diabetes mellitus (T2DM) in China. Methods: We conducted a retrospective cohort study of 10,163 T2DM patients who were not previously diagnosed with CVD from January 2008 to December 2012 in Ningbo, China. The VVV of BP was calculated using five metrics, including standard deviation (SD), coefficient of variation (CV), variation independent of mean, average real variability, and successive variability (SV) of measurements, obtained over a 24-month measurement period. Hazard ratios and 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression models for the associations of variability in BP with risk of CVD. Results: A total of 894 CVD events were observed during a median follow-up of 49.5 months. The hazard ratio in the highest quintile of SD of SBP was 1.24 (95% CI, 1.01 to 1.52) compared with patients in the lowest quintile. The association between higher VVV of DBP and risk of CVD was not consistent across different metrics and sensitivity analyses. Conclusion: Higher VVV of SBP was associated with an increased risk of CVD, irrespective of the mean SBP level. Future studies are needed to confirm these findings.

The Application of Si And Se Fertilizers for Mitigation of Cd Accumulation in Rice

Zhe Chen,Ye-Tao Tang,Rong-Liang Qiu,Bo-Qing Tie 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

SLAM with Improved Schmidt Orthogonal Unscented Kalman Filter

Ming Tang,Zhe Chen,Fuliang Yin 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.4

Simultaneous localization and mapping (SLAM) is a momentous topic for robot navigation to explore uncharted environment. To enhance the accuracy and efficiency, an improved Schmidt orthogonal unscented Kalman filter (ISOUKF) based SLAM algorithm is proposed in this paper. First, based on the Schmidt orthogonal transform (SOT) sampling, a modified unscented Kalman filter (UKF) algorithm is presented. Then, an adaptive fading factor is derived using the strong tracking algorithm, and it is introduced into the prediction covariance to improve tracking ability and accuracy. Next, the Schmidt orthogonal unscented Kalman filter is improved with square root filter to raise the efficiency of SLAM algorithm. Finally, the ISOUKF algorithm is proposed to complete the robot tracking in SLAM. The proposed algorithm provides a high precision robot tracking for SLAM and decreases the computational cost to some extent. Experiment results verify the superiority of the proposed algorithm.

An Improved Adaptive Unscented FastSLAM with Genetic Resampling

Ming Tang,Zhe Chen,Fuliang Yin 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.4

The simultaneous localization and mapping (SLAM) is a significant topic in intelligent robot. In this paper, an improved adaptive unscented FastSLAM with genetic resampling is proposed. Specifically, the adaptive unscented Kalman filter (IAUKF) algorithm is improved as importance sampling of particle filter, where the adaptive factor is used to improve the tracking ability of system and the Huber cost function is constructed to decrease the measurement covariance. Next, the process noise and the measurement noise are assessed by a time varying estimator. Moreover, the resampling in particle filter is carried out by an improved genetic algorithm (GA). Finally, the improved adaptive unscented FastSLAM (IAUFastSLAM) is proposed to complete robot tracking. The proposed algorithm has good tracking performance and obtains reliable state estimation in SLAM. Simulation results reveal the validity of the proposed algorithm.

Robot Tracking in SLAM with Masreliez-Martin Unscented Kalman Filter

Ming Tang,Zhe Chen,Fuliang Yin 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.9

The simultaneous localization and mapping (SLAM) is a significant topic in intelligent robot. In this paper, a robot tracking algorithm in SLAM with Masreliez-Martin unscented Kalman filter (MMUKF) is proposed. A robot dynamic model based on SLAM characteristics is first used as state equation to model the robotic movement, and the measurement equations are deduced by linearizing the motion model. Next, the covariance of process noise is estimated with an adaptive factor to improve tracking performance in the MMUKF. Finally, the MMUKF is employed to estimate the positions of robot and landmarks. The proposed algorithm can complete robot tracking with good accuracy, and obtain reliable state estimation in SLAM. Simulation results reveal the validity of the proposed Algorithm.

High‑frequency planar transformer optimal design and analysis

Yu Tang,Guanghui Wang,Zhe Shi,Jincai Niu 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.2

Due to the rapid development of modern industry, there is an increasing demand for isolated switching power supplies (SMPS) with a high efficiency and a high power density. Magnetic components, which occupy most of the converter volume, have been a key bottleneck in achieving high power density. This paper presents an optimal design method for high power density planar transformers. Applying the principle of flux cancellation, a matrix transformer that originally needed an independent magnetic core was integrated into a single magnetic core to reduce the volume of the core. Meanwhile, a loss model of the transformer is established, and an optimized design method of the winding structure is given according to that model to further reduce the winding loss of the transformer. Finally, an LLC converter with a resonant frequency of 1 MHz is designed to verify the practical performance of the proposed transformer.