http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Han, T H,Tang, Y,Park, Y H,Maynard, J,Li, P,Akbulut, H,Petersen, L,Deisseroth, A Macmillan Publishers Limited 2010 Bone marrow transplantation Vol.45 No.3
We have developed a vaccine, which is designed to induce tumor-associated antigen (TAA)-specific T cells and antibodies in the setting of profound lymphopenia induced by myeloablative therapy and T-cell-depleted bone marrow transplantation. Test mice were injected subcutaneously (sc) with the 32DP210Bcr-Abl cell line, which is positive for the p210Bcr-Abl protein (Group 1). In Group 2, 7 days after injection of the 32DP210Bcr-Abl positive cell line, the mice received 900 cGy total body irradiation (TBI) followed in 1 h by the intravenous infusion of 10 million T-cell-depleted syngeneic bone marrow cells (TCDBMT) (Group 2). The leukemia-bearing group received an intravenous injection of 10 million spleen cells (donor lymphocyte infusions) from unvaccinated (Group 3) and TAA/ecdCD40L-vaccinated (Group 4) syngeneic mice 3 days after completion of the TBI and TCDBMT. Groups 3 and 4 mice received three additional sc vaccinations at 7-day intervals with the TAA/ecdCD40L vaccine, in which the TAA was taken from the junctional peptide of the P210bcr-Abl protein. The survival of Groups 3 and 4 mice was significantly longer than that in Groups 1 and 2 mice. Vaccinated mice from Group 4, which developed complete responses, survived up to 350 days post-injection of the leukemia cells without any evidence of leukemia regrowth.
Tang T.Y.,Lee H.,Kim H.S.,Kim G.H.,Lee B.,Kim H.J.,Lee H.J. 한국물리학회 2021 Current Applied Physics Vol.29 No.-
A nanosecond-pulse power source transfers energy to electrons of atmospheric pressure discharges in a nanosecond-scale rising time and shows different plasma chemistry than a slowly varying sinusoidal discharge. We report how the operation parameters, such as applied voltage, pulse duration, and repetition frequency, affect the discharge characteristics and the surface property of polydimethylsiloxane (PDMS). The applied voltage controls the energy delivery per a pulse cycle, and the repetition frequency dominantly affects the plasma density in a long-term operation. The water contact angle, the optical emission spectroscopy, and the atomic force microscope diagnostics on the PDMS are presented. While the polarity of the nano pulse bias changes the emission length of the plasma jet, the hydrophilicity is not affected by it because the chemical reactions by radicals are more dominant than the physical reactions of charged particles on PDMS.
Yin, Y.-L.,Tang, Z.R.,Sun, Z.H.,Liu, Z.Q.,Li, T.J.,Huang, R.L.,Ruan, Z.,Deng, Z.Y.,Gao, B.,Chen, L.X.,Wu, G.Y.,Kim, S.W. Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.5
Immunomodulatory feed additives might offer alternatives to antimicrobial growth promoters in pig production. This experiment was designed to determine the effects of dietary galacto-mannan-oligosaccharide (GMOS) and chitosan oligosaccharide (COS) supplementation on the immune response in early-weaned piglets. Forty 15-day-old piglets (Duroc$\times$Landrace$\times$Yorkshire) with an average live body weight of $5.6{\pm}0.51kg$ were weaned and randomly assigned to 4 treatment groups that were fed maize-soybean meal diets containing either basal, 110 mg/kg of lincomycin, 250 mg/kg of COS or 0.2% GMOS, respectively, over a 2-week period. Another six piglets of the same age were sacrificed on the same day at the beginning of the study for sampling, in order to obtain baseline values. Interleukin (IL)-1${\beta}$gene expression in peripheral blood monocytes, jejunal mucosa and lymph nodes, as well as serum levels of IL-1${\beta}$ IL-2 and IL-6, IgA, IgG, and IgM, were evaluated for 5 pigs from each group at 15 and 28 days of age. The results indicate that weaning stress resulted in decreases in serum antibody and cytokine levels. Dietary supplementation with GMOS or COS enhanced (p<0.05) IL-1${\beta}$gene expression in jejunal mucosa and lymph nodes, as well as serum levels of IL-1${\beta}$ IL-2, IL-6, IgA, IgG and IgM compared to supplementation with lincomycin. These findings suggest that GMOS or COS may enhance the cell-mediated immune response in early-weaned piglets by modulating the production of cytokines and antibodies, which shows that GMOS or COS have different effects than the antibiotic on animal growth and health.
Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops
Tsai, T. Y.-C.,Choi, Y. S.,Ma, W.,Pomerening, J. R.,Tang, C.,Ferrell, J. E. American Association for the Advancement of Scienc 2008 Science Vol.321 No.5885
<P>A simple negative feedback loop of interacting genes or proteins has the potential to generate sustained oscillations. However, many biological oscillators also have a positive feedback loop, raising the question of what advantages the extra loop imparts. Through computational studies, we show that it is generally difficult to adjust a negative feedback oscillator's frequency without compromising its amplitude, whereas with positive-plus-negative feedback, one can achieve a widely tunable frequency and near-constant amplitude. This tunability makes the latter design suitable for biological rhythms like heartbeats and cell cycles that need to provide a constant output over a range of frequencies. Positive-plus-negative oscillators also appear to be more robust and easier to evolve, rationalizing why they are found in contexts where an adjustable frequency is unimportant.</P>
Hu, X -T,Zhang, F -B,Fan, Y -C,Shu, X -S,Wong, A H Y,Zhou, W,Shi, Q -L,Tang, H -M,Fu, L,Guan, X -Y,Rha, S Y,Tao, Q,He, C Macmillan Publishers Limited 2009 Oncogene Vol.28 No.26
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular movements. We identified PLCD1 as a downregulated gene in aerodigestive carcinomas through expression profiling and epigenetic characterization. We found that PLCD1 was expressed in all normal adult tissues but low or silenced in 84% (16/19) gastric cancer cell lines, well correlated with its CpG island (CGI) methylation status. Methylation was further detected in 62% (61/98) gastric primary tumors, but none of normal gastric mucosa tissues. PLCD1 methylation was significantly correlated with tumor high stage. Detailed methylation analysis of 37 CpG sites at the PLCD1 CGI by bisulfite genomic sequencing confirmed its methylation. PLCD1 silencing could be reversed by pharmacological demethylation with 5-aza-2′-deoxycytidine, indicating a direct epigenetic silencing. Ectopic expression of PLCD1 in silenced gastric tumor cells dramatically inhibited their clonogenicity and migration, possibly through downregulating MMP7 expression and hampering the reorganization of cytoskeleton through cofilin inactivation by phosphorylation. Thus, epigenetic inactivation of PLCD1 is common and tumor-specific in gastric cancer, and PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis.Oncogene (2009) 28, 2466–2475; doi:10.1038/onc.2009.92; published online 18 May 2009
Structural Study and Optical Response of Ag:Bi2O3 Nanoswitch Materials
P. Zhou,L. Y. Chen,J. Li,T. A. Tang,Y. H. Wu,Y. R. Chen,Y. Y. Lin 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.5I
Materials are always the .rst power of our science and technology. In this paper, we explored he linear and nonlinear optical responses of silver/bismuth oxide composite thin .lms, with special mphasis on the relation between the third-order nonlinear optical susceptibility and the metal omposition and metal particle size. The intrinsic optical properties of Ag:Bi2O3 composite .lms re revealed for the .rst time by our research. The maximum value of the third-order optical usceptibility A(3) was 4:1 £ 10¡10 esu, which occurred at a 35.7 % Ag concentration.With increasing nnealing temperature, the maximum value of A(3)observed was 2.1 £ 10¡9 esu, which occurred ter heat treatment at 600 ±C. We also studied the structure and the crystallinity of the samples by sing X-ray diraction and atomic force microscope techniques before and after annealing. Based on he femtosecond nanoswitch eect we revealed, the Ag:Bi2O3 composite materials have promising otential applications in next generation communication technology.