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Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity
Yamauchi, Shota,Noguchi, Takuya,Ichijo, Hidenori The Korean Association of Immunobiologists 2008 Immune Network Vol.8 No.1
Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of ASK1 and its involvement in innate immunity.
Molecular mechanism of reactive oxygen species-dependent ASK1 activation in innate immunity
Shota Yamauchi,Takuya Noguchi,Hidenori Ichijo 대한면역학회 2008 Immune Network Vol.8 No.1
Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of ASK1 and its involvement in innate immunity.
Cusp forms on the exceptional group of type
Kim, Henry H.,Yamauchi, Takuya London Mathematical Society 2016 Compositio mathematica Vol.152 No.2
<P>Let $\mathbf{G}$ be the connected reductive group of type $E_{7,3}$ over $\mathbb{Q}$ and $\mathfrak{T}$ be the corresponding symmetric domain in $\mathbb{C}^{27}$. Let ${\rm\Gamma}=\mathbf{G}(\mathbb{Z})$ be the arithmetic subgroup defined by Baily. In this paper, for any positive integer $k\geqslant 10$, we will construct a (non-zero) holomorphic cusp form on $\mathfrak{T}$ of weight $2k$ with respect to ${\rm\Gamma}$ from a Hecke cusp form in $S_{2k-8}(\text{SL}_{2}(\mathbb{Z}))$. We follow Ikeda’s idea of using Siegel’s Eisenstein series, their Fourier-Jacobi expansions, and the compatible family of Eisenstein series.</P>