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Takeya Koichi 한국자원식물학회 1993 한국자원식물학회 학술심포지엄 Vol.1993 No.-
We in anticancer drug development from natural resources have conceived and used a wide variety of experimental screening systems to support our efforts during the past 20 tears. Screens have been devided to address targets at the molecular, biochemical and cellular levels, both in vivo and in vitro. Screens have been essential for the experimental evaluation of the products from natural sources. In this congress, antitumor screening methods for deveol[ment of new drugs from natural sources and evaluation of their crude drugs are discussed.
( Takeya Tsutsumi ),( Craig Brooks-rooney ),( Bryony Langford ),( Hiroshi Yotsuyanagi ),( Sooji Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Japanese patients with CHC are elderly and may possess more comorbidities and higher pill burden. This study describes the pill burden and comorbidities in Japanese CHC patients in the Medical Data Vision (MDV) claims database. Methods: This was a retrospective cohort study of ≥18 years old patients with CHC (ICD-10: B18.2) from 2008-2016. Age and gender were derived from the database for the most recent CHC visit. Comorbidity prevalence was assessed using ICD-10 codes. Patients who had received all oral direct acting antiviral (DAA) therapy were identified through receipt code for a prescription for a DAA. The average number of tablets (‘pill burden’) taken by DAA-treated patients was calculated for the 90 days prior/post first prescription date of a DAA. Results: The study population included 173,796 patients (mean ±SD age 69±14, 51.7% male), with a large proportion ≥75 years old (40.7%). Prevalent comorbidities included hypertension (41.4%) and type 2 diabetes (18.3%). Patients within the sample experienced a mean of 3.54±2.98 comorbidities, with elderly HCV patients experiencing more comorbidities than younger HCV patients (age group 18-34 vs. 75+; 1.17±1.64 vs. 4.33±3.09; P< 0.001). The 10 most prevalent comorbidities are displayed in Table 1, with most increasing with age. 19,683 patients satisfied criteria for pill burden analysis. Pre- and post- DAA treatment initiation mean pill burden was 4.23±11.4 pills/ day and 6.72±12.17 pills/day, respectively. Pill burden was higher among older patients, with those aged over 75 experiencing mean pill counts of 5.2±13.27 and 7.12±12.05 pre- and post-index, respectively. A greater proportion of elderly patients had a pill burden of >10 after initiating DAA treatment, compared to those in younger age groups (age group 18-34 vs. 75+; 4.2% vs. 21.6%; P<0.001). Conclusions: The majority of Japanese CHC patients are elderly with several comorbidities and high pill burden pre-DAA treatment, which may be an important consideration for CHC regimen selection.
Studies on Anti-cancerous Substances from Higher Plane in East Asian Region
Takeya Koichi 한국자원식물학회 1999 한국자원식물학회 학술심포지엄 Vol.1999 No.-
Ginseng(Panax ginseng C.A. Meyer) is important medicinal plant but requires 4-year cultivation for root harvest because of slow growth. In contrast, ginseng callus and hairy roots grow vigorously and may Produce the same or more biologically active compounds for human health than natural ginseng roots. Therefore, ginseng callus and hairy roots can be used for commercial purposes. Polyacetylene, one of anti-cancer compounds in ginseng, was not detected in the callus cultured on the medium containing 2, 4-B, but cells derived from the callus growth was excellent, The ginseng calli cultured on the medium containing 2mg11 CPA and 0.05mg/1 BA was grown vigorously and produced panaxydol, one of ginseng polyacetylene. The biosynthesis of polyacetylene in callus was not affected by addition of NAA and sucrose in media. The SH medium was better than the MS medium for ginseng callus growth and biosynthesis of panaxydol. Another ginseng anti-cancer compounds, ginsenoside-Rg<TEX>$_3$</TEX>, Rh<TEX>$_1$</TEX>and Rh<TEX>$_2$</TEX> were detected in ginseng hairy roots by heat treatment. Those of Panax ginseng were obtained after root disks of three-year old roots were infected with Agrobacterium rhizogenes Rl000 <TEX>$A_4$</TEX>T in dark condition after one month of culture. The optimum growth of hairy roots was achieved in the culture of 1/2 MS liquid medium in dark(22<TEX>$^{\circ}C$</TEX>) under 60 rpm gyratory shaking. Hairy roots grew well in 5 ι Erlenmeyer flasks, 1ι roller drums, 10ι jar-fermenters, and especially in 20ι air-lift .culture vessels. All heat treatments had remarkably different ginsenoside contents. Eleven ginsenosides were determined in heat treatment, eight in freeze dried hairy roots. Contents of ginsenoside-Rbl , Rb2, Rc, Rd. Re, Rf, and Rg<TEX>$_1$</TEX>tested in all heat treatments were less than those of freeze dried hairy roots. Contents of glnsenoside-Rg<TEX>$_2$</TEX> in heat treatment for 1 hour at 105<TEX>$^{\circ}C$</TEX> was 4
Studies on Anti-Cancerous Substances from Higher Plants in East Asian Region
Koichi Takeya 한국자원식물학회 2000 Plant Resources Vol.3 No.1
To date many kinds of compounds have been obtained from plants kingdom as antineoplastic and anti-cancerous agents. However, there is no special type of compounds for cancer therapy. Various types of substances are effective for various types of cancers and tumors: for instance, alkaloids. lignans, terpenes and steroids etc. Curcumol obtained from Curcuma aromatica was tested and noticed to be effective against cancer of the uterine cervix clinically. Oridonin isolated from Rabdosia ssp. is now investigate for clinical trials in China. Moreover camptothecine isolated from Camptotheca acuminata is also antineoplastic alkaloid, but is very toxic. Chemical modification has been tried to decrease its toxicity This compound is now using as clinical agent. Harringtonin was investigated as an anticancerous drug in China. Taxol, a compound with a taxane ring isolated from the bark of Taxus brevifolia. has been demonstrated to have substantial anticancer activity in patients with solid tumors refractory standard chemotherapy. Supply of this drug has severely limited full exploration of its antineoplastic potential Some efforts are continued in National Cancer Institute(NCI) Washington for surveying various Taxus species for optimal taxol content, improvement in semi-synthesis from baccatin 111, improvement in method of extraction, and development of alternative renewable resources. Further, there are many compounds which have been reported as antineoplastic agents. On the other hand, we have screened on higher plants collected In Japan, China, Korea. Southeast Asia and South America for antineoplastic activity, which has been done using Sarcoma 180 ascites in mice, P388 Iymphocytic leukemia In mice, Chinese hamster lung V-79 cells, P388 cells and nasopharynx carcinoma(KB) cells in our laboratory, as primary screening. In this meeting, I will present on antitumor and cytotoxic substances of the higher plants(Rubis cordifolia, Ailanthus vilmoriniana, Aster tataricus, Taxus cuspidata var. nana, Cephalotaxus harringtonia var. drupacea, etc.) selected from above screening tests.
Yoshitaka Kyou(Yoshitaka Kyou ),Satoru Oishi(Satoru Oishi ),Takeya Takizawa(Takeya Takizawa ),Yuki Yoshimura(Yuki Yoshimura ),Itsuki Hashimoto(Itsuki Hashimoto ),Ryutaro Suzuki(Ryutaro Suzuki ),Reina 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: In the treatment of patients with schizophrenia, pro re nata (PRN) drugs are commonly prescribed for medical indications such as agitation, acute psychiatric symptoms, insomnia, and anxiety. However, high-quality evidence supporting the use of PRN medications is lacking, and these drugs are administered on the basis of clinical experience and habits. Therefore, the actual use of psychotropic PRN drugs and its influence on the patients’ outcomes need to be investigated. Methods: This study included 205 patients who underwent inpatient treatment for schizophrenia. We investigated the prescription of psychotropic drugs before admission and at discharge, as well as the dosing frequency of PRN drugs during hospitalization. We also examined the influence of psychotropic PRN drug use on hospitalization days, antipsychotic polypharmacy, and readmission rates. Results: Patients who used psychotropic PRN drugs during hospitalization had significantly longer hospitalization days (p = 7.5 × 10−4) and significantly higher rates of antipsychotic polypharmacy (p = 2.4 × 10−4) at discharge than those who did not use psychotropic PRN drugs. Moreover, a higher number of psychotropic PRN drugs used per day was associated with higher readmission rates within 3 months of discharge (p = 4.4 × 10−3). Conclusion: Psychotropic PRN drug use is associated with prolonged hospitalization, antipsychotic polypharmacy, and increased readmission rates in inpatients with schizophrenia. Therefore, psychiatric symptoms should be stabilized with regularly prescribed medications without the extensive use of psychotropic PRN drugs. Moreover, a system for monitoring and reexamining PRN drug use needs to be established.