http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Takashi Watanabe,Mikito Ueda,Shin Ishiguro,Yuki Hayashi,Akiko Aoki,Masataka Shinozaki,Kazuko Kato,Kazufumi Akiyama,Kazutaka Shimoda 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.4
Objective: In this study, we investigated the determinants of remission and discontinuation of paroxetine pharmacotherapy in outpatients with panic disorder (PD). Methods: Subjects were 79 outpatients diagnosed with PD who took 10-40 mg/day of paroxetine for 12 months. The candidate therapeutic determinants included the serotonin transporter gene-linked polymorphic region and the −1019C/G promoter polymorphism of the serotonin receptor 1A as genetic factors, educational background and marital status as environmental factors, and early improvement (EI) at 2 weeks as a clinical factor were assessed. The Clinical Global Impression scale was used to assess the therapeutic effects of the pharmacotherapy. Results: Cox proportional hazards regression was performed to investigate the significant predictive factors of remission and discontinuation. EI was only a significant predictive factor of remission. EI was a significant predictive factor of remission (hazard ratio [HR], 2.709; 95% confidence interval [CI], 1.177-6.235). Otherwise, EI and marital status were significant predictive factors of the discontinuation. EI (HR, 0.266; 95% CI, 0.115-0.617) and being married (HR, 0.437; 95% CI, 0.204-0.939) were considered to reduce the risk of treatment discontinuation. In married subjects, EI was a significant predictive factor of the discontinuation (HR, 0.160; 95% CI, 0.045-0.565). However, in unmarried subjects, EI was not a significantly predictive factor for the discontinuation. Conclusion: EI achievement appears to be a determinant of PD remission in paroxetine treatment. In married PD patients, EI achievement also appears to reduce a risk of discontinuation of paroxetine treatment
Takashi Watanabe,Shin Ishiguro,Akiko Aoki,Mikito Ueda,Yuki Hayashi,Kazufumi Akiyama,Kazuko Kato,Kazutaka Shimoda1 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1
Objective-Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for PD in a Japanese population. Methods-In this age-and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), -1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD. Results-No significant differences were evident in the allele frequencies or genotype distributions of the COMT (rs4680), 5-HTTLPR polymorphisms or the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients and controls. Although there were no significant associations of these polymorphisms with in subgroups of PD patients differentiated by gender or in subgroup comorbid with agoraphobia (AP), significant difference was observed in genotype distributions of the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients without AP and controls (p=0.047). Conclusion-In this association study, the 1019C/G (rs6295) promoter polymorphism of the 5-HT1A receptor G/G genotype was associated with PD without AP in a Japanese population.
SHRINKAGE OF VITREOUS BODY CAUSED BY HYDROXYL RADICAL
Park, Myoung-Joo,Shimada, Takashi,Matuo, Yoichirou,Akiyama, Yoko,Izumi, Yoshinobu,Nishijima, Shigehiro The Korean Association for Radiation Protection 2008 방사선방어학회지 Vol.33 No.4
In this study, we examined the effect of hydroxyl radical generated by $\gamma$-ray and UV irradiation on shrinkage of vitreous body. Change in gel ratio of vitreous body and change in the properties of its components (collagen, sodium hyaluronate) were analyzed. By comparing these results, the amount of hydroxyl radical, which induces the considerable shrinkage of vitreous body, was evaluated from theoretical calculation based on experimental condition and some reported kinetic parameters. It was concluded that the integrated amount of hydroxyl radical required to liquefy half of the vitreous body (Vitreous body gel ratio = 50%) was estimated as $140\;{\mu}molg^{-1}$ from $\gamma$-ray irradiation experiment. Also, from UV irradiation experiment result, it was confirmed that the effect of hydroxyl radical is larger than that of other reactive species. The causes of shrinkage of vitreous body are supposed as follows, 1) decrease in viscosity by cleavage of glycoside bond in sodium hyaluronate, 2) leaching of collagen from vitreous body and 3) leaching of crosslinked products and scission products of collagen.
Deposition of Aerosols on Leaves in a Cool-temperate Larch Forest in Northern Hokkaido, Japan
Fukazawa Tatsuya,Murao Naoto,Sato Hisashi,Takahashi Masahiro,Akiyama Masayuki,Yamaguchi Takashi,Noguchi Izumi,Takahashi Hiroyuki,Kozuka Chikara,Sakai Rei,Takagi Kentaro,Fujinuma Yasumi,Saigusa Nobuko 한국대기환경학회 2012 Asian Journal of Atmospheric Environment (AJAE) Vol.6 No.4
Aerosol concentrations at the CC-Lag site in the Teshio Experimental Forest increased from winter to spring and sometimes showed extremely high values associated with Kosa and/or forest-fire events. The range and mean of the mass concentrations of aerosol chemical species were as follows: total particulate mass, 1.2-29, 5.0; elemental carbon, 0.061-2.2, 0.43; organic carbon, 0.059-3.5, 0.79; and sulfate,0.12-6.2, 1.8 μg/m3. The total masses of the deposited particles on hybrid larch and on bamboo leaves were approximately 35 and 30 μg/cm2, respectively. The amounts of soil particles on the leaves were 6 μg/cm2 for the upper part of hybrid larch, 2μg/cm2 for the lower part of hybrid larch, and 1 μg/cm2 for Sasa bamboo leaves. The amounts of deposited black carbon were 2.3 μg/cm2 for the upper part of hybrid larch, 0.6 μg/cm2 for the lower part of hybrid larch, and 0.2 μg/cm2 for Sasa bamboo leaves. Half of the total deposited particular mass was attached on the hybrid larch; however, most of the total deposited mass was adhered on the Sasa bamboo leaves. Regardless of the species, there tend to be more deposited particles on the leaves in the upper part than in the lower part, with only a few meters height difference. Comparing the composition of the deposited particles to that of the atmospheric aerosols without any size cut, the fractions of water-soluble material sulfate and sea salt in the deposited aerosols were about one tenth and one hundredth lower than that in the aerosols, respectively. On the basis of the measured concentration and the deposited amount on leaves, the deposition velocity of black carbon was estimated to be approximately 0.5 cm/s. Aerosol concentrations at the CC-Lag site in the Teshio Experimental Forest increased from winter to spring and sometimes showed extremely high values associated with Kosa and/or forest-fire events. The range and mean of the mass concentrations of aerosol chemical species were as follows: total particulate mass, 1.2-29, 5.0; elemental carbon, 0.061-2.2, 0.43; organic carbon, 0.059-3.5, 0.79; and sulfate,0.12-6.2, 1.8 μg/m3. The total masses of the deposited particles on hybrid larch and on bamboo leaves were approximately 35 and 30 μg/cm2, respectively. The amounts of soil particles on the leaves were 6 μg/cm2 for the upper part of hybrid larch, 2μg/cm2 for the lower part of hybrid larch, and 1 μg/cm2 for Sasa bamboo leaves. The amounts of deposited black carbon were 2.3 μg/cm2 for the upper part of hybrid larch, 0.6 μg/cm2 for the lower part of hybrid larch, and 0.2 μg/cm2 for Sasa bamboo leaves. Half of the total deposited particular mass was attached on the hybrid larch; however, most of the total deposited mass was adhered on the Sasa bamboo leaves. Regardless of the species, there tend to be more deposited particles on the leaves in the upper part than in the lower part, with only a few meters height difference. Comparing the composition of the deposited particles to that of the atmospheric aerosols without any size cut, the fractions of water-soluble material sulfate and sea salt in the deposited aerosols were about one tenth and one hundredth lower than that in the aerosols, respectively. On the basis of the measured concentration and the deposited amount on leaves, the deposition velocity of black carbon was estimated to be approximately 0.5 cm/s.
Luang, Sukanya,Cho, Jung-Il,Mahong, Bancha,Opassiri, Rodjana,Akiyama, Takashi,Phasai, Kannika,Komvongsa, Juthamath,Sasaki, Nobuhiro,Hua, Yan-ling,Matsuba, Yuki,Ozeki, Yoshihiro,Jeon, Jong-Seong,Cairns American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.14
<P>Glycosylation is an important mechanism of controlling the reactivities and bioactivities of plant secondary metabolites and phytohormones. Rice (<I>Oryza sativa</I>) Os9BGlu31 is a glycoside hydrolase family GH1 transglycosidase that acts to transfer glucose between phenolic acids, phytohormones, and flavonoids. The highest activity was observed with the donors feruloyl-glucose, 4-coumaroyl-glucose, and sinapoyl-glucose, which are known to serve as donors in acyl and glucosyl transfer reactions in the vacuole, where Os9BGlu31 is localized. The free acids of these compounds also served as the best acceptors, suggesting that Os9BGlu31 may equilibrate the levels of phenolic acids and carboxylated phytohormones and their glucoconjugates. The Os9BGlu31 gene is most highly expressed in senescing flag leaf and developing seed and is induced in rice seedlings in response to drought stress and treatment with phytohormones, including abscisic acid, ethephon, methyljasmonate, 2,4-dichlorophenoxyacetic acid, and kinetin. Although site-directed mutagenesis of Os9BGlu31 indicated a function for the putative catalytic acid/base (Glu<SUP>169</SUP>), catalytic nucleophile residues (Glu<SUP>387</SUP>), and His<SUP>386</SUP>, the wild type enzyme displays an unusual lack of inhibition by mechanism-based inhibitors of GH1 β-glucosidases that utilize a double displacement retaining mechanism.</P>
Deposition of Aerosols on Leaves in a Cool-temperate Larch Forest in Northern Hokkaido, Japan
Tatsuya, Fukazawa,Naoto, Murao,Hisashi, Sato,Masahiro, Takahashi,Masayuki, Akiyama,Takashi, Yamaguchi,Izumi, Noguchi,Hiroyuki, Takahashi,Chikara, Kozuka,Rei, Sakai,Kentaro, Takagi,Yasumi, Fujinuma,Nob Korean Society for Atmospheric Environment 2012 Asian Journal of Atmospheric Environment (AJAE) Vol.6 No.4
Aerosol concentrations at the CC-Lag site in the Teshio Experimental Forest increased from winter to spring and sometimes showed extremely high values associated with Kosa and/or forest-fire events. The range and mean of the mass concentrations of aerosol chemical species were as follows: total particulate mass, 1.2-29, 5.0; elemental carbon, 0.061-2.2, 0.43; organic carbon, 0.059-3.5, 0.79; and sulfate, 0.12-6.2, 1.8 ${\mu}g/m^3$. The total masses of the deposited particles on hybrid larch and on bamboo leaves were approximately 35 and 30 ${\mu}g/cm^2$, respectively. The amounts of soil particles on the leaves were 6 ${\mu}g/cm^2$ for the upper part of hybrid larch, 2 ${\mu}g/cm^2$ for the lower part of hybrid larch, and 1 ${\mu}g/cm^2$ for Sasa bamboo leaves. The amounts of deposited black carbon were 2.3 ${\mu}g/cm^2$ for the upper part of hybrid larch, 0.6 ${\mu}g/cm^2$ for the lower part of hybrid larch, and 0.2 ${\mu}g/cm^2$ for Sasa bamboo leaves. Half of the total deposited particular mass was attached on the hybrid larch; however, most of the total deposited mass was adhered on the Sasa bamboo leaves. Regardless of the species, there tend to be more deposited particles on the leaves in the upper part than in the lower part, with only a few meters height difference. Comparing the composition of the deposited particles to that of the atmospheric aerosols without any size cut, the fractions of water-soluble material sulfate and sea salt in the deposited aerosols were about one tenth and one hundredth lower than that in the aerosols, respectively. On the basis of the measured concentration and the deposited amount on leaves, the deposition velocity of black carbon was estimated to be approximately 0.5 cm/s.