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      • KCI등재

        Slab analysis of large cylindrical shell rolling considering mixed friction

        Suwen Chen,Hongmin Liu,Yan Peng,Jianliang Sun 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.11

        Large cylindrical shell rolling is an advanced plastic-forming technique that has unequal speed and radius of both its upper and lowerrolls. A theoretical model for a large cylindrical shell rolling that is based on the slab method is proposed, in which the non-uniform normaland shear stresses that act on the vertical sides are considered. A mixed friction model of combined Coulomb and sticking friction isused to present interface friction, to improve the accuracy of the proposed model. The rolling pressure, rolling force, and torque as well asfriction stress can be rapidly and easily calculated through the proposed model at different rolling conditions. The predicted rolling forceis consistent with the experimental result. The research results provide valuable guidelines for both the design and optimization of rollingproduct, process, and equipment.

      • KCI등재

        CpG Array Analysis of Histone H3 Lysine 4 Trimethylation by Chromatin Immunoprecipitation Linked to Microarrays Analysis in Peripheral Blood Mononuclear Cells of IgA Nephropathy Patients

        Suwen Qi,Yong Dai,Weiguo Sui,Ming Yang,Jiejing Chen 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.2

        Purpose: The purpose of the present study was to investigate the aberrance of histone H3 lysine 4 trimethylation (H3K4me3) in patients with IgA Nephropathy (IgAN). Materials and Methods: In this study, H3K4me3 variations in peripheral blood mononuclear cells (PBMCs) from 15 IgAN patients and 15 healthy subjects were analyzed using chromatin immunoprecipitation linked to microarrays analysis (ChIP-chip). ChIP real-time PCR was used to validate the microarray results. Expression analysis by quantitative real-time PCR (qRT-PCR) revealed correlations between mRNA and H3K4me3 levels. DNA methylation status was analyzed by quantitative methylation-specific PCR. Results: We found that 321 probes displayed significant H3K4me3 differences in IgAN patients compared with healthy controls. Among these probes, 154 probes displayed increased H3K4me3and 167 probes demonstrated decreased H3K4me3. For further validation, we selected 4 key relevant genes (FCRL4, GALK2, PTPRN2 and IL1RAPL1) to study. The results of ChIP real-time PCR coincided well with the microarray data. Quantitative RT-PCR revealed the correlations between the mRNA expression and the methylation levels of H3K4me3. Different degrees of DNA methylation alterations appeared on the selected positive genes. Conclusion: Our studies indicated that there were significant alterations in H3K4me3 in IgAN patients. These findings may help to explain the disturbed immunity and abnormal glycosylation involved in IgAN patients.

      • KCI등재

        Orthogonal Analysis and Optimization of a K4-Rating Auto-Lifting Anti-Ram Bollard System

        Ke Cao,Guo-Qiang Li,Suwen Chen,Yu Zhang,Bo Hu 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.2

        The anti-ram bollard system (ABS) is installed around the perimeter of buildings and infrastructures to prevent the penetration of unauthorized vehicles and reduce the blast and debris caused by the vehicle-borne improvised explosive devices (VBIED). Comparing with the fixed anti-ram bollard system (FABS), the auto-lifting anti-ram bollard system (AABS) has the advantage to be set down automatically to allow authorized vehicles passing on. In this paper, a configuration of K4-rating AABS is proposed and a finite-element model is developed to simulate its performance. Differences between vehicle model and real vehicle, effects of boundary conditions are both taken into account. The effectiveness and accuracy of the numerical simulation are validated through predicting the results of relevant experiments. Based on the verified numerical model, 32 groups of numerical experiments of K4-rating AABS are investigated using an orthogonal array L32 (48 ×81). The order and significant levels of nine affecting factors are identified on the basis of the range analysis and variance analysis, respectively. It shows that gaps between substructure and outer sleeve, wall thickness of substructure, wall thickness of steel tube, diameter of steel tube and thickness of stiffening ribs have significant influences on the behavior of AABS. The optimal design is proposed according to the orthogonal analysis.

      • KCI등재후보

        Damage Localization of Steel Beams with Rotational Restraints

        Guo-Qiang Li,Yang Zhang,Suwen Chen 한국강구조학회 2007 International Journal of Steel Structures Vol.7 No.1

        In this paper, a method is presented for damage localization of stel beams with indexes based on natural frequencies becauselocations of beams and not related to the severity of damages is presented. Based on this principle, the universal curve-bankof the natural frequency indexes for damage localization of beams with rotational restraints is established. The effectivenessand universality of the curve-bank have been demonstrated by identifying the damage location of two steel beam specimenswith only first three natural frequencies of the beams. The approach presented may be used for monitoring the damagelocalization of beam-type structures, such as bridges.

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