http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lim, Kyu,Song, Hea-Jeong,Byun, Sang-Hyun,Yun, Kyung-Ah,Son, Mee-Young,Park, Jong-Il,Kweon, Gi-Ryang,Yoon, Wan-Hee,Hwang, Byung-Doo 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-
Epidermal growth factor (EGF) is a potent mitogen for rat hepatocytes and mammalian histone synthesis is functionally and temporally coupled to DNA replication. To gain an insight on the role of EGF in the regulation of H2B histone gene expression in primary hepatocyte cultures, the binding patterns of nuclear proteins to various elements in the H2B histone gene upstream region have been investigated. EGF induced H2B histone mRNA with maximal stimulation reached at 36 hours. The induction of H2B histone mRNA was dependent on the concentration of EGF and almost reduced by actinomycin-D pretreatment. In DNaseⅠ footprinting analysis, one nuclear factor (TATA element-binding protein, TBP) bound at -20 bp (TATA element) in either the absence or presence of EGF. One DNA-protein complex was formed by DNA mobility shift assay when TATA element was incubated with nuclear extract prepared from EGF-free hepatocytes, and the amount of TBP was increased after EGF treatment. These results suggest that TBP may be correlated with with transcriptional regulation of H2B histone gene by EGF in primary hepatocytes.
Evaluation of the Neurological Safety of Epidural Milnacipran in Rats
Lim, Seung-Mo,Shin, Mee-Ran,Kang, Kyung-Ho,Kang, Hyun,Nahm, Francis Sahn-Gun,Kim, Baek-Hui,Shin, Hwa-Yong,Lim, Young-Jin,Lee, Sang-Chul The Korean Pain Society 2012 The Korean Journal of Pain Vol.25 No.4
Background: Milnacipran is a balanced serotonin norepinephrine reuptake inhibitor with minimal side effects and broad safety margin. It acts primarily on the descending inhibitory pain pathway in brain and spinal cord. In many animal studies, intrathecal administration of milnacipran is effective in neuropathic pain management. However, there is no study for the neurological safety of milnacipran when it is administered neuraxially. This study examined the neurotoxicity of epidural milnacipran by observing behavioral and sensory-motor changes with histopathological examinations of spinal cords in rats. Methods: Sixty rats were divided into 3 groups, with each group receiving epidural administration of either 0.3 ml (3 mg) of milnacipran (group M, n = 20), 0.3 ml of 40% alcohol (group A, n = 20), or 0.3 ml of normal saline (group S, n = 20). Results: There were no abnormal changes in the behavioral, sensory-motor, or histopathological findings in all rats of groups M and S over a 3-week observation period, whereas all rats in group A had abnormal changes. Conclusions: Based on these findings, the direct epidural administration of milnacipran in rats did not present any evidence of neurotoxicity in behavioral, sensory-motor and histopathological evaluations.
Lim, Sung-Mee,Im, Dong-Soon The Korean Society of Food Hygiene and Safety 2007 한국식품위생안전성학회지 Vol.22 No.3
동치미로부터 분리한 유산균 (68 균주) 중 Escherichia coli O157에 대한 항균 효과를 나타내는 균주는 Lactobacillus plantarum K11로 동정되었다. 분리균주 La. piantarum K11이 생산한 박테리오신의 항균 활성은 대수증식기 후반부에 12,800 BU/mL로 최대 활성에 이르렀다. 항균 활성은 pepsin, protease, proteinase K, papain, chymotrypsin 및 trypsin 처리에 의해 완전히 소실되었으나, catalase, ${\alpha}-amylase$, lysozyme 및 lipase에 의해서는 영향을 받지 않았으므로 단백질성 물질임을 확인하였다. 게다가, 이 활성은 pH 3.0-9.0의 조건하에서나 -20, 4 및 $25^{\circ}C$에서 30일간의 저장 동안에도 안정하였다. 또한 $100^{\circ}C$에서 30분간 가열처리에도 비교적 안정한 편이었고, chloroform이나 hexane 처리에도 활성에 변함이 없었다. 분리 균주의 박테리오신은 Bacillus spp., Listeria spp. 및 Staphylococcus spp. 등의 일부 식중독균의 억제효과는 나타나지 않았으나, Enterobacter aerogenes와 E. coli 등의 장내세균의 억제에는 효과적이었으며, 특히 640 BU/mL의 박테리오신 처리에 의해서 10시간 배양만에 E. coli O157이 완전하게 사멸되었다. Among 68 strains of lactic acid bacteria (LAB) isolated from Dongchimi, a strain K11 was selected due to its bactericidal activity against Escherichia coli O157 The strain K11 was identified as Lactobacillus plantarum, based on physiological and biochemical characteristics. In the late exponential phase, La. plantarum K11 showed maximum bacteriocin activity (12,800 BU/mL) and maintained until the early stationary phase. The bacteriocin activity was completely inactivated by all the proteolytic enzymes such as pepsin, protease, proteinase K, papain, chymotrypsin, and trypsin, but the activity was not affected by catalase, a-amylase, lysozyme, and lipase, suggesting proteinaceous nature of the bacteriocin. Additionally, this activity was not affected in the pH range from 3.0 to 9.0 and under storage conditions like 30 days at -20,4, or $25^{\circ}C$. Although the bacteriocin activity was absolutely lost after 15 min treatment at 121, it was relatively stable at $70^{\circ}C$ for 60 min or $100^{\circ}C$ for 30 min. The activity was disappeared by treatment with acetone, benzene, ethanol, or methanol, but it was not affected by treatment with chloroform or hexane. The antibacterial activity of the bacteriocin was good against some LAB including Lactobacillus spp., Enterococcus spp., and Streptococcus spp., but not against food-borne pathogens such as Bacillus spp., Listeria spp., and Staphylococcus spp. as well as yeasts and molds. Especially, some intestinal bacteria such as Enterobacter aerogenes and E. coli were significantly affected by the bacteriocin of La, plantarum K11. Furthermore, the addition of 640 BU/mL resulted in the complete clearance of E. coli O157 after 10 hr.
Clinical, Histopathological, and Molecular Characteristics of Papillary Thyroid Microcarcinoma
Lim, Dong-Jun,Baek, Ki-Hyun,Lee, Youn-Soo,Park, Woo-Chan,Kim, Mee-Kyoung,Kang, Moo-Il,Jeon, Hae-Myung,Lee, Jong-Min,Yun-Cha, Bong,Lee, Kwang-Woo,Son, Ho-Young,Kang, Sung-Koo Mary Ann Liebert 2007 Thyroid Vol.17 No.9
Lim, Soo,Kim, Jung Hee,Yoon, Ji Won,Kang, Seon Mee,Choi, Sung Hee,Park, Young Joo,Kim, Ki Woong,Lim, Jae Young,Park, Kyong Soo,Jang, Hak Chul American Diabetes Association 2010 Diabetes care Vol.33 No.7
<P><B>OBJECTIVE</B></P><P>We investigated the prevalence of sarcopenic obesity (SO) and its relationship with metabolic syndrome in a community-based elderly cohort in Korea.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>In this study, 287 men and 278 women aged 65 or older were recruited. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by height squared (Ht<SUP>2</SUP>) (kg/m<SUP>2</SUP>) or by weight (Wt) (%) of <1 SD below the sex-specific mean for young adults. Obesity was defined as a visceral fat area ≥100 cm<SUP>2</SUP>.</P><P><B>RESULTS</B></P><P>The prevalence of SO was 16.7% in men and 5.7% in women with sarcopenia defined by ASM/Ht<SUP>2</SUP>; however, it was 35.1% in men and 48.1% in women by ASM/Wt. Using ASM/Wt, the homeostasis model assessment of insulin resistance of subjects with SO was higher and they were at higher risk for metabolic syndrome (odds ratio [OR] 8.28 [95% CI 4.45–15.40]) than the obese (5.51 [2.81–10.80]) or sarcopenic group (2.64 [1.08–6.44]).</P><P><B>CONCLUSIONS</B></P><P>SO defined by ASM/Wt was more closely associated with metabolic syndrome than either sarcopenia or obesity alone.</P>
Lim, Soo,Shin, Hayley,Song, Jung Han,Kwak, Soo Heon,Kang, Seon Mee,Won Yoon, Ji,Choi, Sung Hee,Cho, Sung Il,Park, Kyong Soo,Lee, Hong Kyu,Jang, Hak Chul,Koh, Kwang Kon American Diabetes Association 2011 Diabetes care Vol.34 No.6
<P><B>OBJECTIVE</B></P><P>The number of people with metabolic syndrome is increasing worldwide, and changes in socioenvironmental factors contribute to this increase. Therefore, investigation of changes in metabolic syndrome and its components in South Korea, where rapid socioenvironmental changes have occurred in recent years, would be foundational in setting up an effective strategy for reducing this increasing trend.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We compared the prevalence and pattern of metabolic syndrome among participants in the Korean National Health and Nutrition Examination Surveys for 1998, 2001, 2005, and 2007. In each survey, stratified, multistage, probability–sampling designs and weighting adjustments were conducted to represent the entire Korean population. The revised National Cholesterol Education Program criteria were used as the definition of metabolic syndrome. All biochemical parameters were measured in a central laboratory.</P><P><B>RESULTS</B></P><P>A total of 6,907 (mean ± SE age 45.0 ± 0.2 years), 4,536 (45.5 ± 0.2), 5,373 (47.1 ± 0.2), and 2,890 (49.9 ± 0.3) Koreans over 20 years of age have participated in the studies in 1998, 2001, 2005, and 2007, respectively. The age-adjusted prevalence of metabolic syndrome increased significantly from 24.9% in 1998, 29.2% in 2001, and 30.4% in 2005 to 31.3% in 2007. Among the five components, the level of low HDL cholesterol increased the most, by 13.8% over the 10 years. Abdominal obesity and hypertriglyceridemia followed, with 8.7 and 4.9% increases, respectively.</P><P><B>CONCLUSIONS</B></P><P>Because dyslipidemia and abdominal obesity were major factors in increasing the prevalence of metabolic syndrome in Koreans for the past 10 years, lifestyle interventions should be conducted at the national level to reduce the burden and consequences of metabolic syndrome.</P>
Lim, Soo,Kang, Seon Mee,Shin, Hayley,Lee, Hak Jong,Won Yoon, Ji,Yu, Sung Hoon,Kim, So-Youn,Yoo, Soo Young,Jung, Hye Seung,Park, Kyong Soo,Ryu, Jun Oh,Jang, Hak C. American Diabetes Association 2011 Diabetes care Vol.34 No.2
<P><B>OBJECTIVE</B></P><P>To improve quality and efficiency of care for elderly patients with type 2 diabetes, we introduced elderly-friendly strategies to the clinical decision support system (CDSS)-based ubiquitous healthcare (u-healthcare<B>)</B> service, which is an individualized health management system using advanced medical information technology.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We conducted a 6-month randomized, controlled clinical trial involving 144 patients aged >60 years. Participants were randomly assigned to receive routine care (control, <I>n</I> = 48), to the self-monitored blood glucose (SMBG, <I>n</I> = 47) group, or to the u-healthcare group (<I>n</I> = 49). The primary end point was the proportion of patients achieving A1C <7% without hypoglycemia at 6 months. U-healthcare system refers to an individualized medical service in which medical instructions are given through the patient’s mobile phone. Patients receive a glucometer with a public switched telephone network-connected cradle that automatically transfers test results to a hospital-based server. Once the data are transferred to the server, an automated system, the CDSS rule engine, generates and sends patient-specific messages by mobile phone.</P><P><B>RESULTS</B></P><P>After 6 months of follow-up, the mean A1C level was significantly decreased from 7.8 ± 1.3% to 7.4 ± 1.0% (<I>P</I> < 0.001) in the u-healthcare group and from 7.9 ± 1.0% to 7.7 ± 1.0% (<I>P</I> = 0.020) in the SMBG group, compared with 7.9 ± 0.8% to 7.8 ± 1.0% (<I>P</I> = 0.274) in the control group. The proportion of patients with A1C <7% without hypoglycemia was 30.6% in the u-healthcare group, 23.4% in the SMBG group (23.4%), and 14.0% in the control group (<I>P <</I> 0.05).</P><P><B>CONCLUSIONS</B></P><P>The CDSS-based u-healthcare service achieved better glycemic control with less hypoglycemia than SMBG and routine care and may provide effective and safe diabetes management in the elderly diabetic patients.</P>