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A Synthetic Chenodeoxycholic Acid Derivative, HS-1200-induced Apoptosis of RBL-2H3 Cells
Byung-Chan Koo,Jeong-Soo Kim,Hyun-Ho Kwak,In-Ryoung Kim,Seung-Eun Lee,Gyoo-Cheon Kim,Hongsuk Suh1,Bong-Soo Park 대한해부학회 2009 Anatomy & Cell Biology Vol.42 No.1
Bile acids and synthetic bile acid derivatives induced apoptosis in various kinds of cancer cells and anticancer effects. Although synthetic chenodeoxycholic acid (CDCA) derivatives have been demonstrated to induce apoptosis of various cancer cells, there is no report on their effect on RBL-2H3 basophilic leukemia cell line to date. Therefore, this study was undertaken to examine in vitro effects of cytotoxicity and growth inhibition, and the molecular mechanism underlying induction of apoptosis in RBL-2H3 cells treated with a synthetic CDCA derivative, HS-1200. The viability and the growth inhibition of RBL-2H3 cells were assessed by MTT assay and clonogenic assay respectively. The Hoechst staining and DNA electrophoresis were conducted to observe RBL-2H3 cells undergoing apoptosis. RBL-2H3 cells were treated with HS-1200, and Western blotting, immunocytochemistry, confocal microscopy, DNA hypoploidy assay, MMP activity and proteasome activity were performed. HS-1200 treatment of RBL-2H3 cells resulted in a time- and does-dependent decrease of cell viability and a does-dependent inhibition of cell growth, and induced apoptotic cell death. Furthermore, HS-1200 treatment result in the alteration of G1 cell cycle-related proteins. And tested RBL-2H3 cells showed several lines of apoptotic manifestation.We presented data indicating that HS-1200 induces apoptois via the proteasome, mitochondria and caspase pathway, and induces the alteration of the G1 cell cycle-related proteins in RBL-2H3 cells. Therefore our data provide the possibility that HS-1200 could be as a novel therapeutic strategy in the allergy treatment.
변속 원활감 향상을 위한 DETENT PIN GROVE 형상 최적화
서홍석(Hongsuk Suh) 한국자동차공학회 2009 한국자동차공학회 부문종합 학술대회 Vol.2009 No.4
In Europe, the proportion of manual transmission cars is over 80%. That is why development of manual transmission considering Europe is important from now on. So in this paper the preferred gearshift feeling in Europe was studied and the principal control factors were selected considering engineering. From the selected control factor, Detent Pin Groove profile was chosen as the key control factor for its analysis was unsatisfied and it has a great influence in improving gearshift feeling. Detent Pin Groove profile was optimized to gain accurate and simple operation of shifting gears. Therefore, improvement of groove profile applying optimization can gain effective results in developing gearshift feeling considering specific region.
( Hongsuk Choi ),( Subin Kim ),( Hayong Song ),( Seokho Suh ),( Hyeong-jin Kim ),( Kwangsup Eom ) 한국부식방식학회 2021 Corrosion Science and Technology Vol.20 No.5
In this work, we proposed a facile method to fabricate the three-dimensional porous copper current collector (3D Cu CC) for a Si-dominant anode in a Li-ion battery (LiB). The 3D Cu CC was prepared by combining chemical etching and thermal reduction from a planar copper foil. It had a porous layer employing micro-sized Cu balls with a large surface area. In particular, it had strengthened attachment of Si-dominant active material on the CC compared to a planar 2D copper foil. Moreover, the increased contact area between a Si-dominant active material and the 3D Cu could minimize contact loss of active materials from a CC. As a result of a battery test, Si-dominant active materials on 3D Cu showed higher cyclic performance and rate-capability than those on a conventional planar copper foil. Specifically, the Si electrode employing 3D Cu exhibited an areal capacity of 0.9 mAh cm<sup>-2</sup> at the 300<sup>th</sup> cycles (@ 1.0 mA cm<sup>-2</sup>), which was 5.6 times higher than that on the 2D copper foil (0.16 mAh cm<sup>-2</sup>).
Role of interpenetrating networks in the device performance of polymer-fullerene photovoltaic cells
김희주,이광희,Hongsuk Suh,Yongyoub Park 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.1
We fabricated polymer-fullerene photovoltaic (PV) devices using conjugated polymer, poly[2- methoxy,5-(2'-ethylhexyloxy)-1,4-phenylene-vinylene] (MEH-PPV), and fullerene-derivative, f6g-1- (3-(methoxycarbonyl)propyl)-f5g-1-pheny [5,6]-C61 (PCBM), composites as active single-layers. By comparing the device characteristics of PV cells with various PCBM concentrations, we investigated the role of PCBM networks in the devices. Our results indicate that charge transport channels formed along the PCBM molecules play an important role in the device performance of polymerfullerene composite PV cells, limiting the device eciency.09e80
Kim, Hee Un,Kim, Ji-Hoon,Suh, Hongsuk,Kwak, Jeonghun,Kim, Dongwook,Grimsdale, Andrew C.,Yoon, Sung Cheol,Hwang, Do-Hoon The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.93
<P>We have found that 9,9′BF can be used as an electron acceptor for P3HT-based OPVs while similar devices using 4,4′BP do not show any photovoltaic effect. This can be related to the respective aromaticity and antiaromaticity of the reduced forms of 9,9′BF or 4,4′BP. The OPV device fabricated using P3HT and 9,9′BF exhibited a PCE of 2.28% with a <I>V</I><SUB>oc</SUB> of 1.07 V, a <I>J</I><SUB>sc</SUB> of 5.04 mA cm<SUP>−2</SUP>, and a FF of 0.42.</P> <P>Graphic Abstract</P><P>We have found that 9,9′BF can be used as an electron acceptor for P3HT-based OPVs while similar devices using 4,4′BP do not show any photovoltaic effect. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc46557h'> </P>