Self-biased Super MOS 복합회로를 응용한 공정검출회로

徐範洙,趙鉉默 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-

A new process detection circuit is proposed. The proposed process detection circuit compares a long channel MOS TR (L > 0.4um) to a short channel MOS TR which uses lowest feature size of the process. The circuit generates the differential current proportional to the deviation of carrier mobilities according to the process variation. This method keep the two TR's drain voltage same by implementing the feedback using a high gain OPAMP. This paper also shows the new design of the simple high gain self-biased rail-to-rail OPAMP using a proposed self-biased super MOS composite circuit. The gain of designed OPAMP is measured over 100dB with 0.2~1.6V wide range CMR in single stage. Finally, the proposed process detection circuit is applied to a differential VCO. The VCO showed that the proposed process detection circuit compensates the process corners successfully and ensures the wide rage operation.

드레인 정규화 감지회로를 이용한 차동 PLL 설계 및 차동 공정보상기법

서범수,조현묵,Suh, Benjamin,Cho, Hyun-Mook 한국전기전자학회 2005 전기전자학회논문지 Vol.9 No.1

본 논문은 공정변화를 검출하여 회로에 반영 및 보상하는 드레인 정규화 검출 (regulated drain detection) 방식과 차동 VCO에 적용하는 기법을 제안하였으며, 제안된 방식과 기법을 검증하기 위하여 저 전압 차동 PLL을 제작하여 그 성능을 검증하였다. 제안된 드레인 정규화 검출 방식과 이를 차동적으로 응용하여 설계된 저-지터 차동 PLL은 실제로 $0.18{\mu}m$ 1-폴리 3-메탈 공정으로 제작되었으며 공정변화에 따른 여러 가지 공정 코너 (corner)에 대한 VCO의 동작을 다양한 모의실험을 통하여 검증하였다. 제작된 PLL은 80MHz - 240MHz의 동작범위를 가지며 전체 die size는 내부 루르필터를 포함하여 $330{\mu}m\;{\times}\;380{\mu}m$이다. 1.8V 공급전압 일때 모든 동작주파수에 대한 트랙킹 지터 특성은 150psec peak-to-peak 이하로 안정적인 성능을 보였다. A process variation compensation method called 'regulated drain detection' is proposed. This paper also shows the how this newly invented method is applied to a typical differential PLL. The proposed RDD(regulated drain detection) and its PLL application has been designed and tested in a $0.18{\mu}m$ 1-poly 3-metal plain digital process so that its stable performance and higher yield can be proven. The implemented PLL aimed to the operation range of 80MHz - 240MHz and the total die size is only $0.18{\mu}m$ including the internal loop filter. The tracking jitter characteristics is measured to less than 150 peak-to-peak under l.8V supply rail.

자기-바이어스 슈퍼 MOS 복합회로를 이용한 공정 검출회로

서범수,조현묵,Suh Benjamin,Cho Hyun-Mook 한국융합신호처리학회 2006 융합신호처리학회 논문지 (JISPS) Vol.7 No.2

본 논문에서는 새로운 개념의 공정 검출 회로를 제안하였다. 제안된 공정 검출 회로는 장채널 트랜지스터와 최소의 배선폭을 갖는 단채널 트랜지스터 사이의 공정변수의 차이를 비교한다. 이 회로는 공정 변이에 따라 발생하는 캐리어 이동도의 차이를 이용하여 이에 비례하는 차동 전류를 생성해 낸다. 이 방법에서는 고 이득 연산증폭기를 사용한 궤환 회로를 구현함으로써 두 개의 트랜지스터의 드레인 전압이 같아지도록 유지한다. 또한, 본 논문은 제안한 자기-바이어스 슈퍼 MOS 복합회로를 이용하여 고 이득 자기-바이어스 rail-to-rail 연산증폭기를 설계하는 새로운 방법을 소개한다. 설계된 연산증폭기의 이득은 단상의 $0.2V{\sim}1.6V$ 공통모드 범위에서 100dB 이상으로 측정되었다 최종적으로, 제안한 공정 검출 회로는 차동 VCO 회로에 직접 적용하였으며, 설계된 VCO 회로를 통해서 공정 검출 회로가 공정 코너들을 성공적으로 보상하고 광범위한 동작 영역에서 안정된 동작을 수행함을 확인할 수 있었다. In this paper, a new process detection circuit is proposed. The proposed process detection circuit compares a long channel MOS transistor (L > 0.4um) to a short channel MOS transistor which uses lowest feature size of the process. The circuit generates the differential current proportional to the deviation of carrier mobilities according to the process variation. This method keep the two transistor's drain voltage same by implementing the feedback using a high gain OPAMP. This paper also shows the new design of the simple high gam self-biased rail-to-rail OPAMP using a proposed self-biased super MOS composite circuit. The gain of designed OPAMP is measured over 100dB with $0.2{\sim}1.6V$ wide range CMR in single stage. Finally, the proposed process detection circuit is applied to a differential VCO and the VCO showed that the proposed process detection circuit compensates the process corners successfully and ensures the wide rage operation.

Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau

Joo, Yuyoung,Schumacher, Benjamin,Landrieu, Isabelle,Bartel, Maria,Smet-Nocca, Caroline,Jang, Ahram,Choi, Hee Soon,Jeon, Noo Li,Chang, Keun-A,Kim, Hye-Sun,Ottmann, Christian,Suh, Yoo-Hun The Federation of American Societies for Experimen 2015 The FASEB Journal Vol.29 No.10

<P>14-3-3 proteins act as adapters that exert their function by interacting with their various protein partners. 14-3-3 proteins have been implicated in a variety of human diseases including neurodegenerative diseases. 14-3-3 proteins have recently been reported to be abundant in the neurofibrillary tangles (NFTs) observed inside the neurons of brains affected by Alzheimer’s disease (AD). These NFTs are mainly constituted of phosphorylated Tau protein, a microtubule-associated protein known to bind 14-3-3. Despite this indication of 14-3-3 protein involvement in the AD pathogenesis, the role of 14-3-3 in the Tauopathy remains to be clarified. In the present study, we shed light on the role of 14-3-3 proteins in the molecular pathways leading to Tauopathies. Overexpression of the 14-3-3σ isoform resulted in a disruption of the tubulin cytoskeleton and prevented neuritic outgrowth in neurons. NMR studies validated the phosphorylated residues pSer214 and pSer324 in Tau as the 2 primary sites for 14-3-3 binding, with the crystal structure of 14-3-3σ in complex with Tau-pSer214 and Tau-pSer324 revealing the molecular details of the interaction. These data suggest a rationale for a possible pharmacologic intervention of the Tau/14-3-3 interaction.—Joo, Y., Schumacher, B., Landrieu, I., Bartel, M., Smet-Nocca, C., Jang, A., Choi, H. S., Jeon, N. L., Chang, K.-A., Kim, H.-S., Ottmann, C., Suh, Y.-H. Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.</P>

The safe and adequate division point of left bile duct during left-side donor hepatectomy

YoungRok Choi,Kwang-Woong Lee,Suk-Won Suh,Tae You,Jose Benjamin Navarro Burgos,Angelica Garcia,Nam-Joon Yi,Kyung-Suk Suh 한국간담췌외과학회 2013 한국간담췌외과학회 학술대회지 Vol.2013 No.4

Result of extracorporeal membrane oxygenation (ECMO) support in cardiac arrest of the liver transplantation recipients

Jeong-Moo Lee,Nam-Joon Yi,Suk-Won Suh,Tae You,Jose Benjamin Navarro Burgos,Angelica Garcia,Kwang-Woong Lee,Kyung-Suk Suh 한국간담췌외과학회 2013 한국간담췌외과학회 학술대회지 Vol.2013 No.4

Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum

Ali, Ahmed Y.,Farrand, Lee,Kim, Ji Young,Byun, Sanguine,Suh, Jeong‐,Yong,Lee, Hyong Joo,Tsang, Benjamin K. Blackwell Publishing Inc 2012 Annals of the New York Academy of Sciences Vol.1271 No.1

<P>Ovarian cancer is the most lethal gynecological malignancy. Cisplatin and its derivatives are first-line chemotherapeutics, and their resistance is a major hurdle in successful ovarian cancer treatment. Understanding the molecular dysregulation underlying chemoresistance is important for enhancing therapeutic outcome. Here, we review two established pathways in cancer chemoresistance. p53 is a major tumor suppressor regulating proliferation and apoptosis, and its mutation is a frequent event in human malignancies. The PI3K/Akt axis is a key oncogenic pathway regulating survival and tumorigenesis by controlling several tumor suppressors, including p53. The interplay between these pathways is well established, although the oncogenic phosphatase PPM1D adds a new layer to this intricate relationship and provides new insights into the processes determining cell fate. Inhibition of the PI3K/Akt pathway by functional food compounds as an adjunct to chemotherapeutics may tip the balance in favor of apoptosis rather than survival, enhancing therapeutic efficacy, and reducing side effects.</P>

The Diarylheptanoid Hirsutenone Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin via Modulation of Apoptosis-inducing Factor and X-linked Inhibitor of Apoptosis

Farrand, Lee,Kim, Ji Young,Byun, Sanguine,Im-aram, Akechai,Lee, Jihoon,Suh, Jeong-Yong,Lee, Ki-Won,Lee, Hyong Joo,Tsang, Benjamin K. American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.3

<▼1><P><B>Background:</B> Resistance of ovarian cancer cells to chemotherapy is a major therapeutic problem.</P><P><B>Results:</B> Hirsutenone induces cisplatin sensitivity via p53, X-linked inhibitor of apoptosis protein, and apoptosis-inducing factor.</P><P><B>Conclusion:</B> Hirsutenone sensitizes resistant ovarian cancer cells to cisplatin.</P><P><B>Significance:</B> Co-treatment with hirsutenone may have the potential to overcome chemoresistance.</P></▼1><▼2><P>Cisplatin (CDDP) and its derivatives are considered first-line treatments for ovarian cancer (OVCA). However, despite initial results that often appear promising, in most cases patients will return with recurrent disease that fails to respond to further chemotherapy. We assayed a number of food phytochemicals with reported PI3K inhibitory ability to identify candidates that can influence CDDP treatment outcomes in chemoresistant OVCA cell lines. A direct comparison revealed that the diarylheptanoid hirsutenone from the tree bark of <I>Alnus hirsuta</I> var. sibirica was superior at inducing CDDP sensitivity in a number of chemoresistant cancer cell lines. Whereas hirsutenone treatment activated p53, its modest efficacy in <I>p53</I>-mutant and -null cell lines suggested the existence of a p53-independent mode of action. Further investigation revealed that hirsutenone causes CDDP-dependent apoptosis in chemoresistant cells by ubiquitin-proteasome-dependent X-linked inhibitor of apoptosis degradation and by enhancing the translocation of apoptosis-inducing factor from the mitochondria to the nucleus. This was found to be, at least in part, under the influence of upstream Akt activity, linking hirsutenone-dependent PI3K inhibition with downstream effects on apoptosis-inducing factor, X-linked inhibitor of apoptosis, and apoptosis. Our findings provide rationale for further investigation of the effects of hirsutenone on chemoresistant OVCA in clinical studies.</P></▼2>