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Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting
Mark Steven Miller,Peter J. Allen,Powel H. Brown,Andrew T. Chan,Margie L. Clapper,Roderick H. Dashwood,Shadmehr Demehri,Mary L. Disis,Raymond N. DuBois,Robert J. Glynn,Thomas W. Kensler,Seema A. Khan 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.1
The Division of Cancer Prevention of the National Cancer Institute (NCI) and the Office of Disease Prevention of the National Institutes of Health co-sponsored the Translational Advances in Cancer Prevention Agent Development Meeting on August 27 to 28, 2020. The goals of this meeting were to foster the exchange of ideas and stimulate new collaborative interactions among leading cancer prevention researchers from basic and clinical research; highlight new and emerging trends in immunoprevention and chemoprevention as well as new information from clinical trials; and provide information to the extramural research community on the significant resources available from the NCI to promote prevention agent development and rapid translation to clinical trials. The meeting included two plenary talks and five sessions covering the range from pre-clinical studies with chemo/immunopreventive agents to ongoing cancer prevention clinical trials. In addition, two NCI informational sessions describing contract resources for the preclinical agent development and cooperative grants for the Cancer Prevention Clinical Trials Network were also presented.
High-density single-nucleotide polymorphism maps of the human genome
Miller, Raymond D.,Phillips, Michael S.,Jo, Inho,Donaldson, Miriam A.,Studebaker, Joel F.,Addleman, Nicholas,Alfisi, Steven V.,Ankener, Wendy M.,Bhatti, Hamid A.,Callahan, Chad E.,Carey, Benjamin J.,C Elsevier 2005 Genomics Vol.86 No.2
<P><B>Abstract</B></P><P>Here we report a large, extensively characterized set of single-nucleotide polymorphisms (SNPs) covering the human genome. We determined the allele frequencies of 55,018 SNPs in African Americans, Asians (Japanese–Chinese), and European Americans as part of The SNP Consortium's Allele Frequency Project. A subset of 8333 SNPs was also characterized in Koreans. Because these SNPs were ascertained in the same way, the data set is particularly useful for modeling. Our results document that much genetic variation is shared among populations. For autosomes, some 44% of these SNPs have a minor allele frequency ≥10% in each population, and the average allele frequency differences between populations with different continental origins are less than 19%. However, the several percentage point allele frequency differences among the closely related Korean, Japanese, and Chinese populations suggest caution in using mixtures of well-established populations for case–control genetic studies of complex traits. We estimate that ∼7% of these SNPs are private SNPs with minor allele frequencies <1%. A useful set of characterized SNPs with large allele frequency differences between populations (>60%) can be used for admixture studies. High-density maps of high-quality, characterized SNPs produced by this project are freely available.</P>
Josefowicz, Steven Z.,Shimada, M.,Armache, A.,Li, Charles H.,Miller, Rand M.,Lin, S.,Yang, A.,Dill, Brian D.,Molina, H.,Park, H.S.,Garcia, Benjamin A.,Taunton, J.,Roeder, Robert G.,Allis, C. Cell Press 2016 Molecular cell Vol.64 No.2
<P>The inflammatory response requires coordinated activation of both transcription factors and chromatin to induce transcription for defense against pathogens and environmental insults. We sought to elucidate the connections between inflammatory signaling pathways and chromatin through genomic footprinting of kinase activity and unbiased identification of prominent histone phosphorylation events. We identified H3 serine 28 phosphorylation (H3S28ph) as the principal stimulation-dependent histone modification and observed its enrichment at induced genes in mouse macrophages stimulated with bacterial lipopolysaccharide. Using pharmacological and genetic approaches, we identified mitogen-and stress-activated protein kinases (MSKs) as primary mediators of H3S28ph in macrophages. Cell-free transcription assays demonstrated that H3S28ph directly promotes p300/CBP-dependent transcription. Further, MSKs can activate both signal-responsive transcription factors and the chromatin template with additive effects on transcription. Specific inhibition of MSKs in macrophages selectively reduced transcription of stimulation-induced genes. Our results suggest that MSKs incorporate upstream signaling inputs and control multiple downstream regulators of inducible transcription.</P>
질소와 인산 시비가 루브라 오리나무 ( Alnus rubra Bong . ) 묘목의 외생균근발달과 질소고정 및 생장에 미치는 영향
구창덕(Chang Duck Koo),(Randolph J . Molina),(Steven L . Miller),(Ching Y . Li) 한국산림과학회 1996 한국산림과학회지 Vol.85 No.1
Red alder(Alnus rubra Bong.) seedlings inoculated with Frankia only or both Frankia and spores of Alpova diplophloeus(Zeller & Dodge) Trappe & Smith were grown in a greenhouse for ten weeks. The ten-week-old seedlings were fertilized with six nitrogen(N) and phosphorus(P) fertility regimes (no fertilization, 10mM NH₄NO₃, 50mM NH₄NO₃, 5mM KH₂PO₄, 10mM NH₄NO₃+5mM KH₂PO₄, and 50mM NH₄NO₃+5mM KH₂PO₄) three times a week for ten weeks. The higher N-fertilization significantly increased mycorrhiza formation by greenhouse contaminant mycorrhizal fungi, but decreased N-fixation and P concentration in nodule tissues. P-fertilization significantly increased nodule and shoot dry weight, and P concentration in plant tissues. When N was highly fertilized, however, the P-fertilization effect disappeared in nodule P concentration but doubled in leaf P concentration. A. diplophloeus inoculation significantly increased diameter growth and CO₂ exchange rate, but decreased leaf dry weight. Our results suggest that the higher N- or P-fertilization affect nitrogenase activity and mycorrhizal development but the effects are changed by their interactions.
VC-dimension and distance chains in $\mathbb{F}_q^d$
Ruben Ascoli,Livia Betti,Justin Cheigh,Alex Iosevich,Ryan Jeong,Xuyan Liu,Brian McDonald,Wyatt Milgrim,Steven J. Miller,Francisco Romero Acosta,Santiago Velazquez Iannuzzelli 강원경기수학회 2024 한국수학논문집 Vol.32 No.1
Given a domain $X$ and a collection $\mathcal{H}$ of functions $h:X\to \{0,1\}$, the Vapnik-Chervonenkis (VC) dimension of $\mathcal{H}$ measures its complexity in an appropriate sense. In particular, the fundamental theorem of statistical learning says that a hypothesis class with finite VC-dimension is PAC learnable. Recent work by Fitzpatrick, Wyman, the fourth and seventh named authors studied the VC-dimension of a natural family of functions $\mathcal{H}_t^{'2}(E): \F_q^2\to \{0,1\}$, corresponding to indicator functions of circles centered at points in a subset $E\subseteq \mathbb{F}_q^2$. They showed that when $|E|$ is large enough, the VC-dimension of $\mathcal{H}_t^{'2}(E)$ is the same as in the case that $E = \mathbb F_q^2$. We study a related hypothesis class, $\Hh_t^d(E)$, corresponding to intersections of spheres in $\mathbb{F}_q^d$, and ask how large $E\subseteq \mathbb{F}_q^d$ needs to be to ensure the maximum possible VC-dimension. We resolve this problem in all dimensions, proving that whenever $|E|\geq C_dq^{d-1/(d-1)}$ for $d\geq 3$, the VC-dimension of $\Hh_t^d(E)$ is as large as possible. We get a slightly stronger result if $d=3$: this result holds as long as $|E|\geq C_3 q^{7/3}$. Furthermore, when $d=2$ the result holds when $|E|\geq C_2 q^{7/4}$.