Regulatory Perspectives on Biosimilars : Quality Issues

Sookyung Suh 大韓藥學會 2008 大韓藥學會 總會 및 學術大會 Vol.2008 No.2

일 지역사회에서 치매환자의 사망률과 위험요인

박수경(Sookyung Park),이준영(Jun-Young Lee),서국희(Guk Hee Suh),장성만(Sung-Man Chang),조맹제(Maeng Je Cho) 대한노인정신의학회 2007 노인정신의학 Vol.11 No.1

Objectives : The aim of this study was to investigate mortality rates and risk factors in dementia patients in a rural cohort. Methods : A total of 114 subjects with clinically diagnosed dementia were followed up for eight years from 1997 to 2005. Their mortality was compared with sociodemographic and clinical variables using the Cox proportional hazards models after adjusting age, sex, and education. Results : During follow-up, the mortality rate of subjects was 80.2% and the mean (SD) duration of survival from at diagnosis to death was 4 years. Mortality in subjects with dementia depended on old age (relative risk [RR] : 1.05;95% confidence interval [CI] : 1.01-1.08), male (RR : 1.61;CI : 1.00-2.59), low Clinical Dementia Rating scale (RR : 1.54;CI : 1.14-2.10), low Activities of Daily Living (RR : 0.72;CI : 0.59-0.89), low Instrumental Activities of Daily Living (RR : 0.83;CI : 0.75-0.92), no physical activity (RR : 0.44;CI : 0.28-0.70), smoking (RR : 1.74;CI : 1.05-2.89). Conclusion : Mortality in dementia depended on age, sex, CDR, ADL, IADL, physical activity, smoking. These findings have important implications that contribute to make the disease management of dementia patients.

[P364] A case of eccrine poroma on the ear helix

( Joongheon Suh ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

An eccrine poroma is a solitary neoplasm composed of group of benign eccrine ductal epithelial cells. Although the most common site of the eccrine poroma is the sole or hand, it can also occur on the nose, eyelids, neck and chest as well. We report a patient who presented with slowly growing nodule on the right ear helix. Initially the lesion was clinically thought to be a keloid or a pyogenic granuloma. However, the skin biopsy specimen revealed a relatively well-defined epidermal anastomosing tumor with monomorphous small cuboidal cells containing round basophilic nuclei throughout the epidermis layer and turned out to be an eccrine poroma.

15 years retrospective study of DRESS syndrome : a single center study

( Joongheon Suh ),( Sookyung Lee ),( Hoyoung Kim ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a syndrome that involves multi-organ and shows variable clinical presentation. Objectives: The purpose of this study is to investigate the common causative drugs, clinical features and prognosis of DRESS, and compare the differences between the steroid use group and non-use group. Methods: Medical records of patients at the Sanggye Paik hospital from 2001 to 2015 were collected. Results: Totally 65 patients were included. The four most common causative drugs were antibiotics (27.7%), anticonvulsants (20%), antituberculosis (16.9%) and allopurinol (16.9%). The mean incubation period was 4 weeks, significantly shorter for 2 weeks in antibiotics (p<0.001), and longer for 6.5 weeks in anticonvulsants (p=0.033). Sixty-three patients were fully recovered with mean recovery time 3.1 (SD 2.2) weeks, 1 patient had sequelae and 1 patient died. Recovery time tended to increase with longer duration of diagnosis from rash onset (p<0.001) and higher serum AST levels (p=0.024). The mean recovery time was 1 week shorter in steroid use group, but not statistically significant (p=0.056). Conclusion: DRESS may be a heterogeneous syndrome with some particular characteristics related to different drugs. The prognosis of DRESS is relatively good and the role of systemic steroid therapy is unclear.

Efficacy of ablative fractional CO₂ laser and bleomycin combination therapy on periungual viral warts

( Joongheon Suh ),( Jaeho Lee ),( Hoyoung Kim ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: The treatment of periungual viral warts is a therapeutic challenge. Result of various treatments can be ineffective and may cause various complications, including permanent nail changes, pain and scar formation. Objectives: To investigate the efficacy and safety of a ablative fractional carbon dioxide laser and bleomycin combination therapy in the treatment of periungual warts. Methods: Wart lesions were treated with prior ablative cabon dioxide fractional laser. Immediately after each fractional laser treatment, bleomycin(1U/mL) was applied on the lesions. The patients were treated every 2 weeks until elimination of the lesions. Results: Twenty six lesions(68.4%) achieved a complete clearance. Three lesions(7.8%) had excellent partial response(>75% improvement). There were no recurrences of those warts that had achieved complete clearance during the follow-up period of 6 months. No significant long-term adverse effects were noted. Only one lesion showed postinflammatory hyperpigmentation, which resolved within 1 month, and five patients(29%) had localized moderate pain for 2 to 3 days after the treatment. Conclusion: Combination therapy of ablative fractional laser and bleomycin is an effective and safe modality to treat periungual warts. Further large controlled studies are necessary.

[P363] A case of extramammary Paget`s diseae on the back

( Joongheon Suh ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Ectopic extramammary paget`s disease(EMPD) is a rare variant of EMPD that develops in non-apocrine regions. We present 70-year-old man in whom ectopic extramammary Paget`s disease(EMPD) affected the lower back. Clinical appearance was suggestive of Bowen`s disease. However, the biopsy specimen and immunohistochemical study results were consistent with EMPD features. The lesion was resected with 1cm safety margin, and was covered with a full thickness local skin graft. Ectopic EMPD is so rare that only a few case EMPD on non-apocrine region have been reported. We thought this EMPD case on the back is interesting enough in that there has been no case reported on this location.

Climate warming induces the activity period prolongation and distribution range expansion of the Asian mantis Hierodula patellifera in South Korea

Shin Sookyung,Kang Duhee,Lee Jongsung,Seock Do Min,Gu Kang Hong,Suh Jae-Hwa,Kyung Oh Hyun,Woo Kim Tae 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.4

The Asian mantis, Hierodula patellifera, is a native species of South-East Asia and has been designated as a Korean Climate Biological Indicator Species. This study aimed to understand the responses of the phenology and dis tribution of H. patellifera to recent climate trends in South Korea as well as predictions for future responses. We constructed a combined dataset consisting of 1169 records ranging from 1984 to 2022. The number of records sharply increased over time and space, with citizen science data accounting for the greatest proportion. Our study confirmed the prolongation of the overall activity period of the Asian mantis over the past seven years caused by the advanced emergence and delayed senescence. The distribution range of the species also expanded towards higher latitudes and inland regions over the last 40 years. Species distribution models showed that temperature-related variables in the summer and winter seasons were the most critical factors influencing its distribution. In the future, suitable habitats for this species are predicted to expand across the entire Korean peninsula as temperatures rise based on the SSP climate scenarios. These results support the suitability of H. patellifera, which prefers warm environments, as a biological indicator of climate change. They suggest consistent monitoring under future climate warming. Our study also provides novel insights into the value of citizen science as a critical monitoring tool for detecting the impacts of climate change on ecosystems.

A case of asymptomatic angioleiomyoma occurring on the sole

( Joongheon Suh ),( Hoyoung Kim ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Angioleiomyoma is a rare and benign smooth muscle tumor derived from the walls of blood vessel. It mainly develops on the lower extremities especially between the knee joint and ankle joint of the middle-aged women. We encountered a 60-year-old man having a 30 year history of a painless 1.5 x 1.5cm-sized flesh to bluish colored subcutaneous nodule on his right sole. Histological examination of the punch biopsy specimen revealed well circumscribed smooth muscle cell proliferation with sporadically remaining vascular structures. Additionally, the specimen was positively stained with smooth muscle actin. On the basis of clinical and histopathological findings, we established the diagnosis of solid type angioleiomyoma. The lesion was removed clearly through the process of punch biopsy. Any recurrence sign or symptom has not been observed over 6 months. Herein, we report an unusual site of angioleiomyoma occurring on the sole.

A case of multinucleate cell angiohistiocytoma: histopathologic findings reflecting its pathogenesis.

( Joongheon Suh ),( Hoyoung Kim ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Multinucleate cell angiohistiocytoma(MCAH) is a peculiar cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on acral regions and face of elderly women. We report a case of 14-year-old man who presented with multiple asymptomatic erythematous papules and single flat brownish plaque on left chest. The brownish plaque was initially a single erythematous papules but brownish color change and size enlargement have been developed over more than 1 year. After that, multiple erythematous papules appeared around the brownish plaque 1 month ago. We performed histologic evaluation at the both site of the papule and the plaque. The brownish plaque lesion histologically showed remarkable proliferation of dilated small vessels in the upper-mid dermis and numerous bizarre-shaped multinucleate cells intermingled with numerous lymphohistiocytes. The erythematous papules, meanwhile, histologically also showed dilated small vessels in the upper-mid dermis and multiple interstitial histiocytic infiltrations but no multinucleate cells were detected. In immunohistochemistry studies, CD68 and vimentin were both positive at the both specimen. Based on the clinico-pathologic findings and immunohistochemistry studies, the diagnosis of MCAH was made. To the best of our knowledge, this is the first documented case of MCAH describing its histologic change, reflecting the mechanism of its pathogenesis.

A case of cutaneous plasmacytosis showing a zosteriform distribution

( Joongheon Suh ),( Hoyoung Kim ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Cutaneous plasmacytosis is a rare skin disorder characterized by multiple reddish brown nodules mainly occurring at the trunk in adults. Histologically, there is a dermal infiltrate of mature plasma cells. A 35-year-old female presented with multiple erythematous to brownish macules and patches at the left side of trunk with a zosteriform distribution. The lesion appeared 4 years ago without any painful or itching symptoms. Histopathological exam revealed the dense dermal patch-like cellular infiltration surrounding the follicles and the nerves. The infiltrate was composed of lymphocytes, histiocytes and plasma cells. Also, the specimen was positively stained with CD138, CD3 and CD20. On the basis of previous findings, we established the diagnosis of cutaneous plasmacytosis. To the best of our knowledge, there has been no cases of cutaneous plasmacytosis occurring in a stripe or on one side of the body, mimicking zosteriform dermatoses. Therefore, we report an unusual case of cutaneous plasmacytosis showing a zosteriform distribution which should be taken into consideration when dermatologists encounter characteristic zosteriform pigmentation lesions in their clinics.