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( Thanh Thi Nguyen ),( Somy Yoon ),( Yi Yang ),( Ho Bin Lee ),( Soo Nok Oh ),( Min Hye Jeong ),( Jong Jin Kim ),( Sung Tae Yee ),( Florin Crisan ),( Cheol Moon ),( Kwang Youl Lee ),( Kyung Keun Kim ) 전남대학교 약품개발연구소 2014 약품개발연구지 Vol.23 No.-
Lichens are symbiotic organisms which produce distinct secondary metabolic products. In the present study, we tested the cytotoxic activity of 17 lichen species against several human cancer cells and further investigated the molecular mechanisms underlying their anti-cancer activity. We found that among 17 lichens species, F. cucullata exhibited the most potent cytotoxicity in several human cancer cells. High performance liquid chromatography analysis revealed that the acetone extract of F. cucullata contains usnic acid, salazinic acid, Squamatic acid, Baeomycesic acid, d-protolichesterinic acid, and lichesterinic acid as subcomponents. MlT assay showed that cancer cell lines were more vulnerable to the cytotoxic effects of the extract than non-cancer cell lines. Furthermore, among the identified subcomponents, usnic acid treatment had a similar cytotoxic effect on cancer cell lines but with lower potency than the extract. At a lethal dose, treatment with the extract or with usnic acid greatly increased the apoptotic cell population and specifically activated the apoptotic signaling pathway; however, using sub-lethal doses, extract and usnic acid treatment decreased cancer cell motility and inhibited in vitro and in vivo tumorigenic potentials. In these cells, we observed significantly reduced levels of epithelialmesenchymal transition (EMn markers and phosphor-Akt, while phosphor-c-Jun and phosphor-ERK1/2 levels were only marginally affected. Overall, the anti-cancer activity of the extract is more potent than that of usnic acid alone. Taken together, F. cucullata and its subcomponent, usnic acid together with additional component, exert anti-cancer effects on human cancer cells through the induction of apoptosis and the inhibition of EMT.
박재균(Park, Jaegyun),이소미(Yi, Somi) 한국신재생에너지학회 2011 한국신재생에너지학회 학술대회논문집 Vol.2011 No.05
태양광발전 시스템의 성능 평가는 신뢰할 수 있는 데이터의 취득 및 분석을 통하여 발전성능을 제시할 수 있다. 발전성능에 영향을 미치는 요인으로는 일사량과 온도 등의 환경적인 요인, 시스템 구성에 따른 기술적인 요인에 의해 결정될 수 있다. 특히, 시스템 구성에 의해 결정되는 기술적인 요인은 태양전지 모듈의 어레이 손실 및 BOS의 자체 손실 등을 분석하여 전체 시스템의 발전성능을 분석하여 그 성능을 평가할 수 있다. 본 논문에서는 기 설치된 태양광발전 시스템에서 취득된 데이터를 통하여 용량별, 지역별에 따른 태양광발전 시스템의 성능 분석과 손실 원인을 분석하였다. 분석결과 시스템의 성능은 환경적인 요인과 기술적인 요인에 의해 발전성능이 달라진다는 것을 확인할 수 있었다. 본 논문의 결과는 향후 태양광 발전 시스템의 성능의 기준을 제시하는 연구를 위한 사전연구로써 유용한 자료가 되리라 믿는다.
Anti-Cancer Effect of Ginsenoside F₂ against Glioblastoma Multiforme in Xenograft Model in SD Rats
Ji Yon Shin,Jung Min Lee,Heon Sub Shin,Sang Yong Park,Jung Eun Yang,Somi Kim Cho,Tae-Hoo Yi 고려인삼학회 2012 Journal of Ginseng Research Vol.36 No.1
The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short. Therefore, this study was conducted to assess the potential of ginsenoside F₂ (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with IC?? of 50 ㎍/mL through apoptosis, confi rmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1 as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 ㎎/㎏ weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced. The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.