Risk for leptomeningeal seeding after resection for brain metastases: implication of tumor location with mode of resection

Ahn, Jun Hyong,Lee, Sang Hyun,Kim, Sohee,Joo, Jungnam,Yoo, Heon,Lee, Seung Hoon,Shin, Sang Hoon,Gwak, Ho-Shin Journal of Neurosurgery Publishing Group 2012 Journal of Neurosurgery Vol.116 No.5

<B>Object</B><P>Surgical spillage has been one of the causative factors for the development of leptomeningeal seeding (LMS) after resection of brain metastases. In this paper, the authors' goal was to define the factors related to the development of LMS and to evaluate the difference according to tumor location.</P><B>Methods</B><P>The authors retrospectively analyzed 242 patients who had undergone resection for brain metastases. The factors investigated included tumor location with proximity to the CSF pathway (that is, contacting, involved with, or separated from the CSF pathway), the method of resection, and the use of the Cavitron Ultrasonic Surgical Aspirator (CUSA).</P><B>Results</B><P>A total of 39 patients (16%) developed LMS at a median of 6.0 months (range 1-42 months) after resection. The risk of developing LMS was significantly higher in patients whose tumors were resected piecemeal than in those whose tumors were removed en bloc, with a hazard ratio (HR) of 4.08 (p < 0.01). The incidence of LMS was significantly higher in patients in whom the CUSA was used, and the HR was 2.64 (p < 0.01). The proximity of tumor to the CSF pathway in the involved group conferred an increased risk of LMS compared with the separated group (HR 11.36, p < 0.01). The risk of piecemeal resection for LMS was significant only in involved lesions (p < 0.01), and the use of the CUSA in both contact and involved lesions increased the incidence of LMS (p < 0.01 and p < 0.03, respectively).</P><B>Conclusions</B><P>The authors suggest that piecemeal resection using the CUSA should be limited because of the risk of postsurgical LMS, especially when the tumor is in contact with the CSF pathway.</P>

Solvent Extraction of U From the Aqueous Solution and Detection of Radioactivity of α and γ Emitting Species

Sohee Cha,Kwangheon Park,Jeongyeon Lee,Ranyeong Choi,Seol Kim,Hogyu Yi,Jong-Pil Jung,Jae Hak Cheong,Sangjoon Ahn,Won Pyo Jeong,Seungyeon Choi 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2

To address the pressing societal concern in Korea, characterized by the imminent saturation of spent nuclear fuel storage, this study was undertaken to validate the fundamental reprocessing process capable of substantially mitigating the accumulation of spent nuclear fuel. Reprocessing is divided into dry processing (pyro-processing) and wet reprocessing (PUREX). Within this context, the primary focus of this research is to elucidate the foundational principles of PUREX (Plutonium Uranium Redox Extraction). Specifically, the central objective is to elucidate the interaction between uranium (U) and plutonium (Pu) utilizing an organic phase consisting of tributyl phosphate (TBP) and dodecane. The objective was to comprehensively understand the role of HNO3 in the PUREX (Plutonium Uranium Redox Extraction) process by subjecting organic phases mixed with TBPdodecane to various HNO3 concentrations (0.1 M, 1.0 M, 5.0 M). Subsequently, the introduction of Strontium (Sr-85) and Europium (Eu-152) stock solutions was carried out to simulate the presence of fission products typically contented in the spent nuclear fuel. When the operation proceeds, the complex structure takes the following form. ??? ??(??) + 2??? ?(??) + 2???(???) ↔ ???(???)? ? 2???(???) Subsequently, separate samples were gathered from both the organic and aqueous phases for the quantification of gamma-rays and alpha particles. Alpha particle measurements were conducted utilizing the Liquid Scintillation Counter (LSC) system, while gamma-ray measurements were carried out using the High-Purity Germanium Detector (HPGe). The distribution ratio for U, Eu (Eu-152), and Sr (Sr-84) was ascertained by quantifying their activity through LSC and HPGe. Through the experiments conducted within this program, we have gained a comprehensive understanding of the selective solvent extraction of actinides. Specifically, uranium has been effectively separated from the aqueous phase into the organic phase using a combination of tributyl phosphate (TBP) and dodecane. Subsequently, samples containing U(VI), Eu(III), and Sr(II) underwent thorough analysis utilizing LSC and HPGe detectors. Our radiation measurements have firmly established that the concentration of nitric acid enhances the selective separation of uranium within the process.

Suicide Rates and Risk Factors among Korean Cancer Patients, 1993-2005.

Ahn, Eunmi,Shin, Dong Wook,Cho, Sung-Il,Park, Sohee,Won, Young-Joo,Yun, Young Ho American Association for Cancer Research 2010 Cancer epidemiology, biomarkers & prevention Vol.19 No.8

<P>BACKGROUND: As the number of cancer survivors increases, suicide risk approaches that of the general population. We therefore investigated suicide rates and risk factors among Korean cancer patients. METHODS: We observed 816,295 cancer patients for 3,007,294 person-years from 1993 to 2005 through a nationwide cancer registry. We calculated their sex- and age-standardized mortality ratios (SMR) and studied suicide risk factors using rate ratios (RR) based on a log-linear Poisson regression model. RESULTS: Compared with the Korean general population, the suicide rate among cancer patients was high [SMR, 2.00; 95% confidence interval (95% CI), 1.91-2.08]. The rates were highest in the year following the cancer diagnosis (SMR, 3.45; 95% CI, 3.19-3.73) and were still elevated 5 years later (SMR, 1.23; 95% CI, 1.12-1.36). The clinical groups at highest risk were male pancreas cancer patients (SMR, 6.01; 95% CI, 4.33-8.33) and female lung cancer patients (SMR, 3.55; 95% CI, 2.55-4.94). The sociodemographic groups at highest risk were those who had no spouse versus those who were married (RR, 1.50; 95% CI, 1.35-1.68), those who were not employed versus those who were (RR, 1.39; 95% CI, 1.26-1.54), and those who did not have high school education versus those who had (RR, 1.52; 95% CI, 1.30-1.79). CONCLUSIONS: Korean cancer patients are at increased risk of suicide. Both clinical and sociodemographic factors play a role. Impact: There is a need for social support and suicide prevention strategies for cancer survivors in Korea. Cancer Epidemiol Biomarkers Prev; 19(8); 2097-105. (c)2010 AACR.</P>

국내 다소비 베이커리 빵류의 지방, 당, 나트륨의 함량 비교

이소희(Sohee Lee),최은지(Eunji Choi),엄지애(Jeeae Aum),윤성원(Sung-Won Yoon),이조원(Jo Won Lee),김현정(Hyun-Jeong Kim),김인환(In-Hwan Kim),이삼빈(Sam-Pin Lee),김혜영(Hye-Young Kim),안장혁(Jang-Hyuk Ahn),문보경(Bo Kyung Moon),서동원(Dong 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.11

포화지방산, 트랜스지방산, 당, 나트륨의 과잉 섭취는 만성질환 발생의 주요 원인이며, 이에 따라 2020년에 개정된 한국인 영양소 섭취기준에서 만성질환 위험감소를 목적으로 이들 영양성분의 새로운 섭취기준인 만성질환위험감소 섭취량을 제정하였다. 본 연구에서는 대한민국 소비자의 관심도가 높고 많이 섭취하는 베이커리 빵 제품의 이들 영양성분 함량 수준을 제품 100 g 기준과 1회 제공량 기준으로 분석한 후, 만성질환위험감소섭취량과 비교하여 평가하였다. 각 영양성분의 함량은 빵의 종류에 따라 큰 차이를 나타내었으나 각 제품의 1회 제공량 기준으로 평가하였을 때 13종의 제품 모두 해당 영양성분의 1일 만성질환위험감소섭취량에 비해 낮은 수준을 보였다. 다만 앙버터와 크루아상은 다른 제품에 비해 높은 포화지방산과 트랜스지방산 함량을 나타내었다. 카스텔라는 포화지방산, 트랜스지방산 함량뿐만 아니라 나트륨 함량도 가장 낮은 반면 당 함량은 가장 높은 특징을 보였다. 통밀식빵, 식빵 등의 식빵류는 다른 제품에 비해 나트륨 함량은 상대적으로 높고 당 함량은 상대적으로 낮은 경향을 나타내었다. 본 연구에서 보고하는 분석 결과 및 비교 결과들은 국가식품영양성분 데이터베이스 구축에 활용될 수 있을 뿐만 아니라 국내 베이커리 빵 제품에 대한 소비자의 올바른 선택과 소비에 도움이 될 것으로 기대된다. This study sought to compare the fat, sugar, and sodium content in commonly consumed bakery bread distributed in Korea and compare these to their chronic disease risk reduction intake (CDRR) values. Samples of 13 different types of bakery bread were analyzed in this study. These comprised nine types of bread considered as key foods which provide 85% of the diet intake of 17 specific nutrients (including fat, sugar, and sodium) and four types of bread that are frequently searched by consumers through internet portal sites and mobile applications. All samples were collected in Seoul during 2020. Sweet red bean butter and croissants showed relatively greater total saturated and trans fatty acid content than the others. Castella had the lowest total saturated and trans fatty acid content and sodium content per 100 g or per serving, while having the greatest total sugar content per 100 g. Whole wheat bread and plain bread tend to have a greater sodium content, but lower total sugar content as compared to the others. The total saturated and total trans fatty acids, total sugar content, and sodium content per serving in all bread were at low levels (i.e., 4.7∼74.4%, 0.5∼20.8%, 3.1∼28.3%, 1.9∼20.3%, respectively) compared to their CDRR values. The reported results can be used to update the Korean food composition database and help consumers make healthy choices in their consumption of bakery foods.

Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea

Son, Sohee,Kang, Ji-Man,Hahn, Younsoo,Ahn, Kangmo,Kim, Yae-Jean The Korean Pediatric Society 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.4

There are very scant data on the epidemiology of primary immunodeficiency diseases (PIDs) in Korea. Here we attempted to estimate the PID epidemiology and disease burden in Korea. A systematic review was performed of studies retrieved from the PubMed, KoreaMed, and Google Scholar databases. Studies on PIDs published in Korean or English between January 2001 and November 2018 were analyzed. The number of PID patients and the healthcare costs were estimated from Health Insurance Review and Assessment Service (HIRA) Korea data for 2017. A total of 398 PID patients were identified from 101 reports. Immunodeficiencies affecting cellular and humoral immunity were reported in 11 patients, combined immunodeficiency with associated or syndromic features in 40, predominantly antibody deficiencies in 144, diseases of immune dysregulation in 58, congenital defects of phagocytes in 104, defects in the intrinsic and innate immunity in 1, auto-inflammatory disorders in 4, complement deficiencies in 36, and phenocopies of PID in none. From the HIRA reimbursement data, a total of 1,162 outpatients and 306 inpatients were treated for 8,166 and 6,149 days, respectively. In addition, reimbursement was requested for 8,200 outpatient and 1,090 inpatient cases and $1,924,000 and $4,715,000 were reimbursed in 2017, respectively. This study systematically reviewed published studies on PID and analyzed the national open data system of the HIRA to estimate the disease burden of PID, for the first time in Korea.

PTP1B inhibitory activity of kaurane diterpenes isolated from <i>Siegesbeckia glabrescens</i>

Kim, Sohee,Na, Minkyun,Oh, Hyuncheol,Jang, Junpil,Sohn, Cheon Bae,Kim, Bo Yeon,Oh, Won Keun,Ahn, Jong Seog Taylor Francis 2006 Journal of enzyme inhibition and medicinal chemist Vol.21 No.4

<P>Protein tyrosine phosphatase 1B (PTP1B) is considered as a therapeutic target for the treatment of diabetes and obesity. In our preliminary screening study, a MeOH extract of the aerial part of <I>Siegesbeckia glabrescens</I> was found to inhibit PTP1B activity at 30 μg/mL. Bioassay‐guided fractionation led to the isolation of two active diterpenes, <I>ent</I>-16&bgr;H,17-isobutyryloxy-kauran-19-oic acid (<B>1</B>) and <I>ent</I>-16&bgr;H,17-acetoxy-18-isobutyryloxy-kauran-19-oic acid (<B>2</B>), along with <I>ent</I>-16&bgr;H,17-hydroxy-kauran-19-oic acid (<B>3</B>). Compounds <B>1</B> and <B>2</B> inhibited the PTP1B activity with IC<SUB>50</SUB> values of 8.7 ± 0.9 and 30.6 ± 2.1 μM, respectively. Kinetic studies suggest that both <B>1</B> and <B>2</B> are non-competitive inhibitors of PTP1B. However, compound <B>3</B> substituted with a hydroxyl group at C-17 in kaurane-type showed no inhibitory effects towards PTP1B.</P>

다문화가정청소년의 이중문화수용성과 성취동기와의 관계연구: 사회적위축의 매개효과

주소희 ( Sohee Ju ),오인근 ( Inkeun Oh ),안세진 ( Sejin Ahn ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.3

본 연구는 다문화가정청소년을 대상으로 이중문화수용성이 성취동기에 미치는 영향에서 사회적 위축이 매개효과의 역할을 하는지 검증하는데 목적이 있다. 이를 위해 다문화청소년패널조사(MAPS: multicultural adolescents panel study) 중 8차년도 자료를 사용하였다. 사회적 위축의 매개효과를 확인하기 위해 회귀분석과 Sobel검증을 실시하였다. 연구결과, 첫째, 다문화가정청소년의 이중문화수용태도가 높을수록 사회적 위축수준이 낮아지는 것으로 나타났다. 둘째, 이중문화수용태도가 증가할수록 다문화청소년의 성취동기는 높아지는 것으로 나타났다. 마지막으로 사회적위축의 매개효과검증결과 이중문화수용성은 사회적 위축을 매개로 하여 성취동기에 부분매개효과가 있는 것으로 검증되었다. 본 연구결과를 토대로 다문화청소년의 성취동기를 향상하기 위해 이중문화수용을 위한 방안과 사회적위축을 감소시키기 위한 다양한 개입전략을 제언하였고 후속연구의 방향을 제시하였다. This study examined the mediating effect of social withdrawal in the relationship between bicultural acceptance and achievement motivation among multicultural adolescents. To achieve this, the participants of the 8th year of Multicultural Adolescents Panel Study (MAPS) were used for the data analysis. In order to explore the social withdrawal’s mediating effect, regression analysis and Sobel test were used. The results were as followed. First, multicultural adolescents’ social withdrawal decreased as their bicultural acceptance increased. Second, multicultural adolescents’ achievement motivation increased as their bicultural acceptance increased. Lastly, social withdrawal had a partially significant mediating effect in the relationship between bicultural acceptance and achievement motivation among multicultural adolescents. Based on the study results, this study suggested the direction of future studies and the necessity of more interventions and strategies to increase bicultural acceptance and to decrease social withdrawal for the increase of multicultural adolescents’ achievement motivation.

Effects of Black Ginseng Extract on Wrinkle Improvement and Anti-inflammation in Human Keratinocyte (HaCaT) Cells

Wonyeoung Choi,Sohee Ahn,Gye Won Lee,Young Ho Cho 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

Colloidal Single-Layer Quantum Dots with Lateral Confinement Effects on 2D Exciton

Jin, Ho,Ahn, Minji,Jeong, Sohee,Han, Jae Hyo,Yoo, Dongwon,Son, Dong Hee,Cheon, Jinwoo American Chemical Society 2016 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.138 No.40

<P>Controlled lateral quantum confinement in single-layer transition-metal chalcogenides (TMCs) can potentially combine the unique properties of two-dimensional (2D) exciton with the size-tunability of exciton energy, creating the single-layer quantum dots (SQDs) of 2D TMC materials. However, exploring such opportunities has been challenging due to the limited ability to produce well-defined SQDs with sufficiently high quality and size control, in conjunction with the commonly observed inconsistency in the optical properties. Here, we report an effective method to synthesize high-quality and size-controlled SQDs of WSe2 via multilayer quantum dots (MQDs) precursors, which enables grasping a clear picture of the role of lateral confinement on the optical properties of the 2D exciton. From the single-particle optical spectra and polarization anisotropy of WSe2 SQDs of varying sizes in addition to their ensemble data, we reveal how the properties of 2D exciton in single-layer TMCs evolve with increasing lateral quantum confinement.</P>

Effect of Rhodiola sachalinesis Extract Fermented with Bovista plumbea on Cognitive Function Improvement in Neuronal PC12 Cells

Wonyeoung Choi,Sohee Ahn,Jiwon Jeong,Seulgi Shin,Chae won Park,Minsol Hong,Yujin Cha,Gye Won Lee,Young Ho Cho 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10