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( Jie Gao ),( Shunyi Feng ),( Yong Li ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.6
Background/Aims: This study tested the hypothesis that prolonged low-dose cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)-induced lung injury in rats. Methods: PQ (25 mg/kg) was administered intraperitoneally to induce PQ-intoxicated rat model. The rats were randomly divided into four groups: control group (1 mL/day saline solution for 14 days), PQ group (1 mL/day saline solution for 14 days after PQ exposure), pulse group (15 mg/kg/day CTX in 1 mL of saline solution for 2 days and subsequent 1 mL/day saline solution for 12 days), and prolonged low-dose group (15 mg/kg/day CTX in 1 mL of saline solution for 2 days and subsequent 1.5 mg/kg/day CTX in 1 mL of saline solution for 12 days). A 14- day follow-up was conducted to determine the survival rat, and lung hydroxyproline (HYP), wet-to-dry weight ratios (W/Dc) and histopathological changes were evaluated. Results: Results showed similar survival rate (55% vs. 50%, p > 0.05) between prolonged low-dose and pulse groups. Lung W/Dc (4.94 ± 0.38 vs. 5.47 ± 0.28, p < 0.01), HYP (3.34 ± 0.29 μg/mg vs. 3.65 ± 0.19 μg/mg, p < 0.001), and fibrosis score (2.69 ± 0.84 vs. 3.13 ± 0.63, p < 0.05) were lower in prolonged low-dose group than those in the pulse group. Conclusions: These findings suggested prolonged low-dose CTX treatment after pulse therapy could attenuate PQ-induced lung injury in rats.
Isolation of formaldehyde-degrading bacteria and the evaluation of the degradation characteristics
Menglei Wang,Shumin Xu,Shunyi Li,Rencheng Zhu 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.75 No.-
A formaldehyde-degrading bacteria strain, B1, was isolated. Strain B1 was characterized morphologically,physiologically and biochemically, and it was identified as Pseudomonas putida. Then, the formaldehydebiodegradation characteristics were evaluated in a biofilter. A formaldehyde removal rate above 90% wasmaintained when inlet loading was below 38.9 mg L 1 h 1. In addition, strain B1 quickly becamedominant bacteria when the reactor was restarted following a 30-days’ disruption, illustrating that thestrain is both adaptable and resilient. The numerical simulation results demonstrate that the maximumdegradation rates in the biofilter with strain B1 are betterfitted with the Haldane model.
Continuous-Time Deadbeat <tex> $H_{2}$</tex> FIR Filter
Ahn, Choon Ki,Shmaliy, Yuriy S.,Zhao, Shunyi,Li, Hongyi IEEE 2017 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS PART 2 E Vol.64 No.8
<P>This brief proposes a new continuous-time state-space H-2 finite impulse response (FIR) filter with the embedded deadbeat property for linear systems undergoing external disturbances. The new filter is called the continuous-time deadbeat H-2 FIR filter (CTDH2FF). The proposed filter demonstrates H-2 performance under disturbances and the dead-beat property otherwise. The CTDH2FF can be implemented by solving two matrix differential equations for given boundary conditions. A new formula for the minimum H-2 norm of the CTDH2FF is also discussed. Numerical simulations show that the proposed filter has much better robustness against unexpected short-term model changes than the existing filters.</P>