Emotional Level of Sadness for Normal and Dementia Subjects by NIRS

Shinichi Yoshino,Katsuhisa Furuta,Tetsuo Shiotsuki,Yukihito Suzuki,Hideto Shimizu,Hiroki Takase 동국대학교 정보융합기술원 2010 International Journal of Assistive Robotics and Sy Vol.11 No.1

This paper proposes a method to measure the level of sadness by the 52 channels signals of near infrared spectroscopy (NIRS). Normal and dementia subjects are measured while they watch the sad video story. The analysis has been done by using the first principal component of 52 measured signals, and the paper proposes to classify sadness into two classes; sequence of emotional reactions defining ‘dynamic sadness’ and accumulation of sadness defining ‘static sadness’. Both represent the feeling of sadness. They are measured quantitatively by the power over the certain frequencies and the time average of principal components of the measured NIRS signals. The measured signals of the normal subjects show that weight distribution parameters are rather large in the prefrontal cortex area corresponding from 32 to 52 channels, which indicates the subjects understanding the story. This paper shows that the difference of the sad emotion between the normal and dementia subjects is found by using both time average and power of the first principal component of NIRS signals over the whole measurement time. These informations may be used to test brain activities of both normal and dementia subjects. The proposed approach can be used to measure other brain activities using NIRS signals.

Application of Real-Time Tumor-Tracking and Gated Rdiotherapy System for Unresectable Pancreatic Cancer

안용찬,Shinichi Shimizu,Hiroki Shirato,Takayuki Hashimoto,Yasuhiro Osaka,Xiao-Qing Zhang,Tatsuya Abe,Masao Hosokawa,Kazuo Miyasaka 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.4

Herein is reported our experience of radiation therapy using a real-time tumor-tracking and gated radiotherapy (RTRT) system for inoperable pancreatic cancer. Three unresectable pancreatic cancer patients were treated with intraoperative electron beam radiation therapy, at the time of open biopsy, and postoperative external beam radiation therapy using an RTRT system with a 2.0mm diameter gold ball implanted into the pancreas. The total BED'sα/β=10 was intended to be equivalent to that of delivering 60 Gy by 2.0Gy/fraction, while the actual dose schedules were individualized. The movement of the pancreas was analyzed based on the 3-dimensional marker positions during the RTRT. The side effects and tumor responses were evaluated. During the RTRT course, the average movement of markers in the x (left to right), y (cranial to caudal) and z (dorsal to ventral) directions were 3.0mm (1.7-5.2mm), 5.2mm (3.5-6.8mm) and 3.5mm (2.7-5.1 mm), respectively. During and after the course of postoperative radiation therapy, no acute side effects of RTOG grade II or higher were detected. The objective tumor responses, as evaluated by CT scans 3 months after the treatment, were 2 partial responses and no response in one patient. Using the RTRT technique the margin of treatment planning and the possible errors in target localization were reduced, and the 3-dimensional movement of the internal marker implanted in the pancreas was able to be analyzed.

High Dose Three-Dimensional Conformal Boost Using the Real-Time Tumor Tracking Radiotherapy System in Cervical Cancer Patients Unable to Receive Intracavitary Brachytherapy

박희철,Shinichi Shimizu,Akio Yonesaka,Kazuhiko Tsuchiya,Yasuhiko Ebina,Hiroshi Taguchi,Norio Katoh,Rumiko Kinoshita,Masayori Ishikawa,Noriaki Sakuragi,Hiroki Shirato 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.1

Purpose: The purpose of this study is to evaluate the clinical results of treatment with a high dose of 3-dimensional conformal boost (3DCB) using a real-time tracking radiation therapy (RTRT) system in cervical cancer patients. Materials and Methods: Between January 2001 and December 2004, 10 patients with cervical cancer were treated with a high dose 3DCB using RTRT system. Nine patients received whole pelvis radiation therapy (RT) with a median dose of 50 Gy (range, 40-50 Gy) before the 3DCB. The median dose of the 3DCB was 30 Gy (range, 25-30 Gy). Eight patients received the 3DCB twice a week with a daily fraction of 5 Gy. The determined endpoints were tumor response, overall survival, local failure free survival, and distant metastasis free survival. The duration of survival was calculated from the time of the start of radiotherapy. Results: All patients were alive at the time of analysis and the median follow-up was 17.6 months (range, 4.9-27.3 months). Complete response was achieved in nine patients and one patient had a partial response. The 1- and 2-year local failure free survival was 78.8% and 54%, respectively. The 1- and 2-year distant metastasis free survival was 90% and 72%, respectively. Late toxicity of a grade 2 rectal hemorrhage was seen in one patient. A subcutaneous abscess was encountered in one patient. Conclusion: The use of the high dose 3DCB in the treatment of cervical cancer is safe and feasible where intracavitary brachytherapy (ICBT)is unable to be performed. The escalation of the 3DCB dose is currently under evaluation.

Percutaneous metallic stent placement for malignant afferent loop syndrome via the blind end of the jejunal limb after biliary reconstruction

Yozo Sato,Shohei Chatani,Takaaki Hasegawa,Shinichi Murata,Takamichi Kuwahara,Kazuo Hara,Yasuhiro Shimizu,Yoshitaka Inaba 소화기인터벤션의학회 2021 International journal of gastrointestinal interven Vol.10 No.1

Background: Malignant afferent loop syndrome occurs after biliary reconstruction and is difficult to treat because of the complicated anatomical changes. The aim of this study was to investigate the safety and efficacy of percutaneous metallic stent placement for malignant afferent loop syndrome via the blind end of the jejunal limb after biliary reconstruction. Methods: Percutaneous metallic stent placement via the jejunal limb was performed in five male patients (median age, 68 years; range, 51–88 years) with malignant afferent loop syndrome following pancreatoduodenectomy or bile duct resection with reconstruction at our institute from June 2009 to April 2019. Reconstruction was performed using a modified Child’s method or the Roux-en-Y method, and blind end of the jejunal limb was surgically fixed to the abdominal wall. Percutaneous drainage of the afferent loop was performed via the blind end of the jejunal limb. Subsequently, percutaneous metallic stent placement was performed via the same route. Technical success, clinical success, and complications were retrospectively evaluated. Results: Percutaneous metallic stent placement via the blind end of the jejunal limb was successfully achieved in all six procedures. Additional metallic stent placement was performed due to tumor ingrowth in a patient. Drainage catheters were removed from three patients, clamped in one, and could not be removed in one. Clinical success was achieved in four patients (80%) without major complications. Conclusion: Percutaneous metallic stent placement for malignant afferent loop syndrome via the blind end of the jejunal limb after biliary reconstruction could be a safe and effective procedure.

Percutaneous metallic stent placement for malignant afferent loop syndrome via the blind end of the jejunal limb after biliary reconstruction

Yozo Sato,Shohei Chatani,Takaaki Hasegawa,Shinichi Murata,Takamichi Kuwahara,Kazuo Hara,Yasuhiro Shimizu,Yoshitaka Inaba 소화기인터벤션의학회 2021 Gastrointestinal Intervention Vol.10 No.1

Background: Malignant afferent loop syndrome occurs after biliary reconstruction and is difficult to treat because of the complicated anatomical changes. The aim of this study was to investigate the safety and efficacy of percutaneous metallic stent placement for malignant afferent loop syndrome via the blind end of the jejunal limb after biliary reconstruction. Methods: Percutaneous metallic stent placement via the jejunal limb was performed in five male patients (median age, 68 years; range, 51–88 years) with malignant afferent loop syndrome following pancreatoduodenectomy or bile duct resection with reconstruction at our institute from June 2009 to April 2019. Reconstruction was performed using a modified Child’s method or the Roux-en-Y method, and blind end of the jejunal limb was surgically fixed to the abdominal wall. Percutaneous drainage of the afferent loop was performed via the blind end of the jejunal limb. Subsequently, percutaneous metallic stent placement was performed via the same route. Technical success, clinical success, and complications were retrospectively evaluated. Results: Percutaneous metallic stent placement via the blind end of the jejunal limb was successfully achieved in all six procedures. Additional metallic stent placement was performed due to tumor ingrowth in a patient. Drainage catheters were removed from three patients, clamped in one, and could not be removed in one. Clinical success was achieved in four patients (80%) without major complications. Conclusion: Percutaneous metallic stent placement for malignant afferent loop syndrome via the blind end of the jejunal limb after biliary reconstruction could be a safe and effective procedure.

Percutaneous transsplenic obliteration of ectopic varices following pancreaticoduodenectomy with portal vein resection and splenic vein ligation

Shohei Chatani,Yozo Sato,Nozomi Okuno,Takaaki Hasegawa,Shinichi Murata,Hidekazu Yamaura,Kazuo Hara,Yasuhiro Shimizu,Yoshitaka Inaba 소화기인터벤션의학회 2021 International journal of gastrointestinal interven Vol.10 No.2

Left-sided portal hypertension following pancreaticoduodenectomy (PD) with portal vein resection and splenic vein ligation may cause ectopic variceal formation, potentially resulting in life-threatening bleeding. We report of a 79-year-old male suffering from severe anemia and melena after PD. Emergency endoscopy and contrast-enhanced computed tomography (CECT) revealed ectopic varices at the anastomosis site of pancreaticojejunostomy. An interventional radiology approach was preferred over surgical and endoscopic treatment because of the poor general condition and altered anatomy. In the first procedure, percutaneous transhepatic retrograde obliteration was performed using the coaxial double balloon-occlusion technique. Although hemostasis was obtained, re-bleeding occurred two months later. CECT revealed the development of another collateral pathway and the recurrence of varices. Insufficient embolization of the afferent vein was considered the cause of recurrence. Therefore, a percutaneous transsplenic approach was used, and complete embolization of varices was achieved. When transhepatic retrograde obliteration is not effective, transsplenic antegrade obliteration can be a useful therapeutic option.

Percutaneous transsplenic obliteration of ectopic varices following pancreaticoduodenectomy with portal vein resection and splenic vein ligation

Shohei Chatani,Yozo Sato,Nozomi Okuno,Takaaki Hasegawa,Shinichi Murata,Hidekazu Yamaura,Kazuo Hara,Yasuhiro Shimizu,Yoshitaka Inaba 소화기인터벤션의학회 2021 Gastrointestinal Intervention Vol.10 No.2

Left-sided portal hypertension following pancreaticoduodenectomy (PD) with portal vein resection and splenic vein ligation may cause ectopic variceal formation, potentially resulting in life-threatening bleeding. We report of a 79-year-old male suffering from severe anemia and melena after PD. Emergency endoscopy and contrast-enhanced computed tomography (CECT) revealed ectopic varices at the anastomosis site of pancreaticojejunostomy. An interventional radiology approach was preferred over surgical and endoscopic treatment because of the poor general condition and altered anatomy. In the first procedure, percutaneous transhepatic retrograde obliteration was performed using the coaxial double balloon-occlusion technique. Although hemostasis was obtained, re-bleeding occurred two months later. CECT revealed the development of another collateral pathway and the recurrence of varices. Insufficient embolization of the afferent vein was considered the cause of recurrence. Therefore, a percutaneous transsplenic approach was used, and complete embolization of varices was achieved. When transhepatic retrograde obliteration is not effective, transsplenic antegrade obliteration can be a useful therapeutic option.

Organic light emitting diodes with nanostructured ultrathin layers at the interface between electron- and hole-transport layers

Keizo Kato,Kazuki Takahashi,Keisuke Suzuki,Takayuki Sato,Kazunari Shinbo,Futao Kaneko,Hidehiko Shimizu,Nozomu Tsuboi,Toyoyasu Tadokoro,Shinichi Ohta 한국물리학회 2005 Current Applied Physics Vol.5 No.4

Organic light emitting diodes (OLEDs) with nanostructured ultrathin layers inserted at the interface between electron- and hole-transport layers were investigated. The fundamental structure of the OLEDs fabricated by a vacuum evaporation method wasindium-tin-oxide (ITO) anode/copper phthalocyanine (CuPc)/N,N0-diphenyl-N,N0-bis(3-methylphenyl)-1,10-diphenyl-4,40-diamine(TPD)/8-hydroxyquinoline aluminum (Alq3)/LiF/Al cathode. Fullerene (C60) and rhodamine B (RhB) molecules were used as thenanosutructured ultrathin layers inserted at the interface between the Alq3 and TPD layers. The electroluminescent (EL) propertieshave been measured for the OLEDs with C60 and RhB ultrathin layers and the dependences on the thickness and the position of theinserted layers were examined. For the OLEDs with the C60 ultrathin layer, the improvements of the drive voltage and EL eciencywere observed. The OLED with the inserted C60 ultrathin lm of a monolayer thickness showed the highest eciency, which wastwice as large as that without C60 layer. On the contrary, the improvements were not observed for the OLEDs with the RhB ul-trathin layer..