Heightened anti-oxidative and anti-inflammatory activity of selective lactobacillus starter derived from Samjunghwan

Narae Shin,Jing-Hua Wang,Ahtsham Hussain,Kyung-Sun Han,Soo-kyeong Lim,Dongwoo Lim,Abuzar Ansari,Hojun Kim 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

ER stress was induced in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain

Nara Shin,Enji Zhang,Min-Hee Yi,Dong Woon Kim 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.8

손 끝 온도변화가 젊은 성인의 다중 손가락 동작에 미치는 효과

Shin, Narae,Xu, Dayuan,Song, Jun Kyung,Park, Jaebum 한국운동역학회 2019 한국운동역학회지 Vol.29 No.3

Objective: This study examined the effects of stimulating fingertip temperature on the patterns of force sharing and stability properties during multi-finger force production tasks. Method: 9 adult subjects (male: 3, female: 6, age: $26.11{\pm}4.01yrs$, height: $169.22{\pm}5.97cm$, weight: $61.44{\pm}11.27kg$) participated in this study. The experiment consisted of three blocks: 1) maximal voluntary contraction (MVC) task, 2) single-finger ramp task to quantify enslaving (i.e., unintended force production by non-task fingers), and 3) 12 trials of multi-finger steady-state force production task at 20% MVC. There were three temperature conditions including body-temperature (i.e., control condition), $40^{\circ}C$, and $43^{\circ}C$, and the stimulation was given to the index finger only for all experimental conditions. Results: There were no significant differences in the MVC forces, enslaving, and the accuracy of performance during the steady-state task between the conditions. However, the share of stimulated index finger force increased with the index fingertip temperature, while the share of middle finger force decreased. Also, the coefficient of variation of both index and middle finger forces over repetitive trials increased with the index fingertip temperature. Under the framework of the uncontrolled manifold (UCM) hypothesis used to quantify indices of multi-finger synergies (i.e., stability property) stabilizing total force during the steady-state task, the two variance components within the UCM analysis increased together with the fingertip temperature, while no changes in the synergy indices between the conditions. Conclusion: The current results showed that fingertip temperature stimulation only to index finger does not affect to muscle force production capability of multi-finger, independence of individual fingers, and force production accuracy by the involvement of all four fingers. The effect of fingertip temperature on the sharing pattern and force variation may be due to diffuse reflex effects of the induced afferent activity on alpha-motoneuronal pools. However, the unchanged stability properties may be the reflection of the active error compensation strategies by non-stimulated finger actions.

Uncoupled Endothelial Nitric Oxide Synthase Enhances p-Tau in Chronic Traumatic Encephalopathy Mouse Model

Shin, Nara,Kim, Hyeong-geug,Shin, Hyo Jung,Kim, Sena,Kwon, Hyeok Hee,Baek, Hyunjung,Yi, Min-Hee,Zhang, Enji,Kim, Jwa-Jin,Hong, Jinpyo,Lee, Sun Yeul,Lee, Wonhyung,Triantafillu, Ursula L.,Kim, Cuk-Seong Mary Ann Liebert 2018 ANTIOXIDANTS AND REDOX SIGNALING Vol. No.

손 끝 온도변화가 젊은 성인의 다중 손가락 동작에 미치는 효과

( Narae Shin ),( Dayuan Xu ),( Jun Kyung Song ),( Jaebum Park ) 한국운동역학회 2019 한국운동역학회지 Vol.29 No.3

Objective: This study examined the effects of stimulating fingertip temperature on the patterns of force sharing and stability properties during multi-finger force production tasks. Method: 9 adult subjects (male: 3, female: 6, age: 26.11±4.01 yrs, height: 169.22±5.97 cm, weight: 61.44±11.27 kg) participated in this study. The experiment consisted of three blocks: 1) maximal voluntary contraction (MVC) task, 2) single-finger ramp task to quantify enslaving (i.e., unintended force production by non-task fingers), and 3) 12 trials of multi-finger steady-state force production task at 20% MVC. There were three temperature conditions including body-temperature (i.e., control condition), 40℃, and 43℃, and the stimulation was given to the index finger only for all experimental conditions. Results: There were no significant differences in the MVC forces, enslaving, and the accuracy of performance during the steady-state task between the conditions. However, the share of stimulated index finger force increased with the index fingertip temperature, while the share of middle finger force decreased. Also, the coefficient of variation of both index and middle finger forces over repetitive trials increased with the index fingertip temperature. Under the framework of the uncontrolled manifold (UCM) hypothesis used to quantify indices of multi-finger synergies (i.e., stability property) stabilizing total force during the steady-state task, the two variance components within the UCM analysis increased together with the fingertip temperature, while no changes in the synergy indices between the conditions. Conclusion: The current results showed that fingertip temperature stimulation only to index finger does not affect to muscle force production capability of multi-finger, independence of individual fingers, and force production accuracy by the involvement of all four fingers. The effect of fingertip temperature on the sharing pattern and force variation may be due to diffuse reflex effects of the induced afferent activity on alpha-motoneuronal pools. However, the unchanged stability properties may be the reflection of the active error compensation strategies by nonstimulated finger actions.

Nanoscale reduction of resistivity and charge trap activities induced by carbon nanotubes embedded in metal thin films

Shin, Narae,Kim, Jeongsu,Shekhar, Shashank,Yang, Myungjae,Hong, Seunghun Elsevier 2019 Carbon Vol.141 No.-

<P><B>Abstract</B></P> <P>We mapped the nanoscale reduction of resistivity and noise source activities induced by metallic single walled carbon nanotubes (m-SWCNTs) embedded in gold thin films. In this method, current and noise maps of m-SWCNTs/gold hybrid thin films were recorded using a conducting probe in contact with the surface, and the maps were utilized to estimate the nanoscale variation of resistivity (<I>ρ</I>) and the density distribution of noise sources (<I>N</I> <SUB>eff</SUB>) generating electrical noises in the hybrid thin film. The m-SWCNTs/gold hybrid thin films with a 5 nm thick gold layer exhibited 300% improved conductivity compared to that of pristine gold thin films. Additionally, the regions with embedded m-SWCNTs showed significantly reduced noise source densities compared with pristine gold film regions. These results clearly show that embedded m-SWCNTs improve the conductivity and reduce electrical noises of metallic electrodes. Interestingly, we observed that the <I>ρ</I> and the <I>N</I> <SUB>eff</SUB> on both m-SWCNTs/gold hybrid and pristine gold regions exhibited a scaling behavior of <I>ρ</I> ∝ <I>N</I> <SUB>eff</SUB> <SUP>0.5</SUP>, implying the hopping charge conduction and noise characteristics of m-SWCNTs/gold hybrid films. Our works can be a useful guideline for the development of high performance electrodes based on CNTs.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Surgical Outcomes of Centrifugal Continuous-Flow Implantable Left Ventricular Assist Devices: Heartmate 3 versus Heartware Ventricular Assist Device

Shin Kinam,Cho Won Chul,Shin Nara,Kim Hong Rae,Kim Min-Seok,Chung Cheol Hyun,Jung Sung-Ho 대한심장혈관흉부외과학회 2024 Journal of Chest Surgery (J Chest Surg) Vol.57 No.2

Background: Left ventricular assist devices (LVADs) are widely employed as a therapeutic option for end-stage heart failure. We evaluated the outcomes associated with centrifugal- flow LVAD implantation, comparing 2 device models: the Heartmate 3 (HM3) and the Heartware Ventricular Assist Device (HVAD). Methods: Data were collected from patients who underwent LVAD implantation between June 1, 2015 and December 31, 2022. We analyzed overall survival, first rehospitalization, and early, late, and LVAD-related complications. Results: In total, 74 patients underwent LVAD implantation, with 42 receiving the HM3 and 32 the HVAD. A mild Interagency Registry for Mechanically Assisted Circulatory Support score was more common among HM3 than HVAD recipients (p=0.006), and patients receiving the HM3 exhibited lower rates of preoperative ventilator use (p=0.010) and extracorporeal membrane oxygenation (p=0.039). The overall early mortality rate was 5.4% (4 of 74 patients), with no significant difference between groups. Regarding early right ventricular (RV) failure, HM3 implantation was associated with a lower rate (13 of 42 [31.0%]) than HVAD implantation (18 of 32 [56.2%], p=0.051). The median rehospitalization-free period was longer for HM3 recipients (16.9 months) than HVAD recipients (5.3 months, p=0.013). Furthermore, HM3 recipients displayed a lower incidence of late hemorrhagic stroke (p=0.016). In the multivariable analysis, preoperative use of continuous renal replacement therapy (odds ratio, 22.31; p=0.002) was the only significant predictor of postoperative RV failure. Conclusion: The LVAD models (HM3 and HVAD) demonstrated comparable overall survival rates. However, the HM3 was associated with a lower risk of late hemorrhagic stroke.

Biphenyl- and Fluorene-Based <i>o</i>-Carboranyl Compounds: Alteration of Photophysical Properties by Distortion of Biphenyl Rings

Shin, Nara,Yu, Seokhyeon,Lee, Ji Hye,Hwang, Hyonseok,Lee, Kang Mun American Chemical Society 2017 Organometallics Vol.36 No.8

<P>Four biphenyl- and fluorene-based o-carboranyl compounds, 4-[2-(p-n-butylphenyl)-1-o-carboran-1-yl]-biphenyl (1B), 4,4 ''-bis[2-(p-n-butylphenyl)-1-o-carboran-1-yl]-biphenyl (2B), 2-[2-(p-n-butylphenyl)-1-o-carboran-1-yl]-fluorene (1F), and 2,7-bis[2-(p-n-butylphenyl)-1-o-carboran-1-yl]fluorene (2F), were prepared and fully characterized by multinuclear NMR spectroscopy and elemental analysis. The crystal structures of 1B and 2B, analyzed by single-crystal X-ray diffraction, exhibited distinct distortions of the central biphenyl rings with dihedral angles of 44.2 and 33.1 degrees. In photoluminescence measurements, fluorene-based carboranyl compounds in the rigid state (e.g., in solution at 77 K and as films) exhibited a noticeable emission in the low-energy region below 400 nm. 1F displayed a low-energy emissive trace in solution at ambient temperature, whereas biphenyl-based carboranes mainly exhibited high-energy emissions above 400 nm. TD-DFT calculations on the first excited singlet (S-1) state of each compound suggested that the emission in the low-energy region involves intramolecular charge transfer (ICT) between the carborane and central phenylene rings, indicating that the radiative decay of these ICT bands could be enhanced by preventing the distortion of the central biphenyl groups. Furthermore, less distortion on the biphenyl rings of the biphenyl-based analogues at Si in the optimized structures supports that these phenylenes must be flat for the formation of stable excited states. Comparison of the quantum efficiency (Phi(PL)) and radiative decay constants (k(r)) of the o-carboranes also reveals definitively that the structural features of the biphenyl groups can have a decisive effect on those photophysical properties.</P>

공공사회복지서비스 전달의 지역별 차이 : 서울시 주민센터 사회복지공무원의 기초수급자 관리를 중심으로

신나래 ( Shin Narae ),길현종 ( Kil Hyeonjong ) 한국사회복지연구회 2016 사회복지연구 Vol.47 No.4

본 연구는 주민센터 사회복지공무원의 국민기초생활보장 수급자 관리를 통해, 지역에 따라 공공사회복지서비스 수요적 차원에서의 환경적 특성 차이와 공급적 차원에서의 서비스 질과 양에 어떠한 차이가 발생하는지 확인해 보고자 하였다. 이를 위해 본 연구에서는 서울시에서 수급자 비율이 높은 지역과 낮은 지역의 8개 주민센터에서 사회복지(주민생활지원)팀 소속 사회복지담당공무원 15인을 대상으로 면접조사를 실시하였다. 면접조사의 결과에 따르면, 지역에 따라 사회복지공무원 1인이 담당하는 국민기초생활보장제도 수급자 세대수의 차이(11-450세대)가 발생하였으며, 이를 바탕으로 사회복지담당공무원이 경험하는 부담의 형태나 내용도 다른 것으로 나타났다. 또한 주거형태, 민간자원의 활용 가능성, 방문상담이 현실적으로 어려운 이유, 일선담당자와 중간관리자의 사회복지전문성 등 사회복지서비스의 다양한 측면에서 지역적 차이가 발생하는 것을 확인할 수 있었다. 이와 같은 분석결과를 바탕으로 일선 공공사회복지서비스 전달에 있어, 특히 서비스의 질에 부정적 영향을 미칠 수 있는 요인들을 개선하기 위하여 구체적 방안들을 논의하였다. This study aims to elaborate differences of demand and supply in welfare service delivery upon regions. For this purpose, in-depth interviews were conducted with 15 welfare bureaucrats from Dong offices among largest and smallest portions of recipients in Seoul. The results indicated that there were significant differences in the proportion of welfare bureaucrats versus welfare recipients (11-450 households) of the National Basic Livelihood Guarantee System, the amount of available private sector resources, and the difficulty of providing visitation counseling upon regions. Research implications were discussed further to address regional disparities of welfare services.

마이크로웨이브를 이용한 효율적인 탈산소탈수(DODH) 반응: 갈락토스 유래 아디픽산의 합성

신나라 ( Nara Shin ),권소현 ( Sohyun Kwon ),김영규 ( Young Gyu Kim ) 한국공업화학회 2017 공업화학 Vol.28 No.2

나일론의 단량체인 아디픽산을 바이오매스인 갈락토스로부터 얻기 위한 효율적인 합성법을 개발하였다. 백금촉매를 이용한 갈락토스의 산화반응을 통해 얻어진 갈락타릭산으로부터 마이크로웨이브를 이용한 탈산소탈수(DODH)반응을 통하여 30 min의 매우 짧은 반응 시간 안에 97%의 높은 수율로 아디픽산의 주요 중간체인 뮤코네이트를 합성하였다. 생성된 뮤코네이트는 팔라듐 촉매를 이용한 수소화 반응 및 가수분해 반응을 통하여 성공적으로 나일론의 단량체인 고순도의 아디픽산으로 전환되었다. An efficient synthetic process for bio-based adipic acid, a monomer for nylon 66, was developed from galactose. Galactaric acid, prepared from a mild oxidation of galactose using a Pt catalyst, was successfully converted to muconate, a key intermediate for adipic acid, by an efficient microwave-assisted DODH (deoxydehydration) reaction. The high efficiency of the microwave-assisted reaction greatly reduced the overall reaction time to 30 min. and resulted in an excellent yield of 97% of muconate. The catalytic hydrogenation of muconate followed by the acidic hydrolysis successfully produced the desired adipic acid in high purity after recrystallization.