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- 저자 : Shaojun Bai (검색결과 2 건)
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Shaojun Bai,Chunlong Li,Xiangyu Fu,Jian Liu,Shuming Wen 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.61 No.-
The interaction between sulfide-ion species and smithsonite surfaces in the absence with and without ammonia liquor was investigated. The results of zeta potential and sulfide ion adsorption indicated that NH3·H2O addition promoted the transfer of sulfur in the pulp solutions onto the smithsonite surfaces. Time-of-flight secondary ion mass spectrometry and X-ray photo-electron spectroscopy analysis indicated that the zinc sulfide species was composed of zinc monosulfide and zinc polysulfide and was reinforced by NH3·H2O addition. The distribution ratio of polysulfide in the whole S species increased. The results shed light on reinforcement of the smithsonite sulfidation mechanism with ammonia liquor addition.
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Qiang Feng,Yanbin Ren,Aijun Hou,Jing Guo,Zhezhe Mao,Shaojun Liu,Boya Wang,Zhichao Bai,Xiaoying Hou 한국유방암학회 2021 Journal of breast cancer Vol.24 No.2
Purpose: This study aimed to investigate the changes in microRNA-130a (miR-130a) and its correlation with cardiotoxicity during epirubicin/cyclophosphamide followed by docetaxel plus trastuzumab (EC-D+T) adjuvant chemotherapy in human epidermal growth factor receptor-2-positive (HER2+ ) breast cancer patients. Methods: A total of 72 HER2+ breast cancer patients who underwent resection and were scheduled to receive EC-D+T adjuvant therapy were consecutively enrolled. The expression of miR-130a and cardiotoxicity (defined as any of the following situations: 1) absolute decline of left ventricular ejection fraction (LVEF) ≥ 10% and LVEF < 53%; 2) heart failure; 3) acute coronary artery syndromes; and 4) fatal arrhythmia) were assessed every 3 months throughout the 15-month EC-D+T treatment. Results: The accumulating cardiotoxicity rate was 12 (16.7%), of which the incidence of heart failure, acute coronary syndrome, life-threatening arrhythmias, ΔLVEF ≥ 10%, and LVEF < 53% was 0 (0.0%), 1 (1.4%), 0 (0.0%), and 12 (16.7%), respectively. Baseline miR-130a expression was negatively correlated with LVEF (%) and positively correlated with cardiac troponin I. The expression of miR-130a gradually increased in both cardiotoxicity and noncardiotoxicity patients during EC-D+T treatment, while the increment of miR-130a was more obvious in cardiotoxicity patients compared with non-cardiotoxicity patients. Further logistic regression and receiver operating characteristic curve analysis indicated that miR-130a was an independent predictive factor for increased cardiotoxicity risk. Conclusion: MiR-130a increases constantly and predicts high cardiotoxicity risk during ECD+T adjuvant chemotherapy in HER2+ breast cancer patients.
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