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Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis
Seunghee Jun(Seunghee Jun),Hyunjin Park(Hyunjin Park),Ui-Jeong Kim(Ui-Jeong Kim),Eun Jeong Choi(Eun Jeong Choi),Hye Ah Lee(Hye Ah Lee),Bomi Park(Bomi Park),Soon Young Lee(Soon Young Lee),Sun Ha Jee(Su 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis. METHODS: Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis. RESULTS: Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males. CONCLUSIONS: Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.
Kim, Jun-Tae,Son, Min-Hui,Lee, Duk-Hee,Seong, Won Joon,Han, Seunghee,Chang, Yoon-Seok American Chemical Society 2015 Environmental science & technology Vol.49 No.12
<P>Heavy metals and persistent organic pollutants (POPs), including Pb, Cd, T-Hg, MeHg, PCDD/Fs, PCBs, PBDEs, PCNs, and PBDD/Fs, were analyzed in 20 paired samples of cord blood, maternal blood, maternal urine, and placenta. The samples were collected from pregnant mothers and neonates from South Korea in 2010. The distribution of heavy metals among the samples varied with their physicochemical characteristics. The concentrations of Pb and Hg in the maternal and the cord blood samples were significantly correlated each other, implying efficient transplacental transport (TPT). Cd and Hg were accumulated in the placenta, forming protein conjugates, and T-Hg was higher in the cord blood samples than the maternal blood samples due to the binding affinity of Hg with fetal proteins. POPs generally showed the highest concentrations in the maternal serum samples, and the POPs levels in the cord serum and the placenta samples were dependent on the degree of halogenation. The TPT of POPs was seemingly related to lipoprotein transportation. Some PBDE congeners, however, showed their highest concentrations in the cord serum samples, suggesting an additional TPT mechanism. This is the first study to detect PCNs and PBDD/Fs in the cord serum samples, showing that the PCN levels were comparable to other POPs. According to the principal component analysis (PCA) results of the contaminant levels, POPs and heavy metals showed significantly different characteristics, whereas PBDEs had an intermediate attribute. Despite the limited number of participants, the comprehensive analysis of trace contaminants in the paired sample sets enabled us to infer the distribution and TPT mechanism of various contaminants.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/esthag/2015/esthag.2015.49.issue-12/es5051309/production/images/medium/es-2014-051309_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/es5051309'>ACS Electronic Supporting Info</A></P>
MicroRNA expression profiling of p-phenylenediamine treatment in human keratinocyte cell line
Hwa Jun Cha,Ok-Kyu Lee,Soo Yeon Kim,Jung-Min Ko,Su Young Kim,Ji Hye Son,Hyun Joo Han,Shunhua Li,Soo Young Kim,Kyu Joong Ahn,In-Sook An,Sungkwan An,Seunghee Bae 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.1
p-Phenylenediamine (PPD), a black dye used in hair coloring and tattoos, irritates the skin, leading to cell cycle arrest, apoptosis, and reactive oxygen species (ROS) generation. MicroRNAs (miRNAs) are well known regulators of these side effects. The aim of the present study was to evaluate PPD-induced miRNA expression profile alterations in human keratinocytes. First, we demonstrated that PPD reduced HaCaT cell viability by inducing cell cycle arrest and death, elevating cellular ROS levels and decreasing the migration rate. In addition, 67 miRNAs were upregulated by at least 5-fold in PPD-treated HaCaT cell and 17 miRNAs were downregulated by at least 5- fold in PPD-treated HaCaT cell. Using bioinformatics, we identified a relationship between PPD-mediated miRNA changes and cell death, cell cycle arrest, generation of ROS, and migration repression. Target genes of PPD-regulated miRNAs were involved in cell proliferation, apoptosis, skin development, and aging. Thus, our results establish a role for miRNAs in regulating PPD-induced cell death, cell cycle arrest, ROS generation, and repression of migration in human keratinocytes.
STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex
Lee, Seunghee,Shen, Rongkun,Cho, Hyong-Ho,Kwon, Ryuk-Jun,Seo, So Yeon,Lee, Jae W.,Lee, Soo-Kyung National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.28
<P>The motor neuron (MN)–hexamer complex consisting of LIM homeobox 3, Islet-1, and nuclear LIM interactor is a key determinant of motor neuron specification and differentiation. To gain insights into the transcriptional network in motor neuron development, we performed a genome-wide ChIP-sequencing analysis and found that the MN–hexamer directly regulates a wide array of motor neuron genes by binding to the HxRE (hexamer response element) shared among the target genes. Interestingly, STAT3-binding motif is highly enriched in the MN–hexamer–bound peaks in addition to the HxRE. We also found that a transcriptionally active form of STAT3 is expressed in embryonic motor neurons and that STAT3 associates with the MN–hexamer, enhancing the transcriptional activity of the MN–hexamer in an upstream signal-dependent manner. Correspondingly, STAT3 was needed for motor neuron differentiation in the developing spinal cord. Together, our studies uncover crucial gene regulatory mechanisms that couple MN–hexamer and STAT-activating extracellular signals to promote motor neuron differentiation in vertebrate spinal cord.</P>
다중 식별자를 이용한 Adversarial Autoencoder 기반 제조 공정 이상 탐지
이승희(Seunghee Lee),백준걸(Jun-Geol Baek) 대한산업공학회 2021 대한산업공학회지 Vol.47 No.2
When unexpected problems occur in manufacturing process, it is necessary to configure an anomaly detection system to monitor and control them. Abnormal data are critical because they cause a decrease in yield and poor quality. If abnormal data is not detected, the process continues and the loss becomes greater. Abnormal data have fewer numbers than normal data, resulting in class imbalance problems. Therefore, we solve the data imbalance problem by learning distribution of normal data only. Unlike conventional methods, adversarial autoencoder (AAE) is able to create distributions similar to the original data through competitive learning using discriminator. This paper proposes adversarial autoencoder with multiple discriminators, a method to learn the distribution of normal data more accurately by adding two discriminators to AAE. We use Long Short-Term Memory (LSTM) layer to fit the time series characteristics. Experiments confirm that the method proposed in this paper show great anomaly detection performance.
Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells
Bae, Seunghee,Lee, Eun-Mee,Cha, Hwa Jun,Kim, Karam,Yoon, Yeongmin,Lee, Hyunjin,Kim, Jongran,Kim, Yu-Jeong,Lee, Hong Ghi,Jeung, Hoi-Kyung,Min, Yoo Hong,An, Sungkwan Springer-Verlag 2011 Molecules and cells Vol.32 No.3
Bae, Seunghee,Kim, Karam,Cha, Hwa Jun,Choi, Yeongmin,Shin, Shang Hun,An, In-Sook,Lee, Jae Ho,Song, Jie-Young,Yang, Kwang Hee,Nam, Seon Young,An, Sungkwan Lychnia 2014 International journal of oncology Vol.45 No.4
<P>The polycomb group RING finger protein, B-cell?specific moloney murine leukemia virus integration site?1 (BMI1), has emerged as a key regulator of cell proliferation, cell cycle, cell immortalization, chemoresistance and radioresistance. Although the radioresistant effect of BMI1 has been thoroughly investigated, the effectiveness of this factor on low-dose radiation (LDR) resistance has not been explored. Here, we demonstrate that BMI1 is not critical for altering cell viability or cell growth in response to LDR, but BMI1 changes cellular gene expression profiles in response to LDR. Normal human dermal fibroblasts (NHDFs) stably expressing BMI1 short hairpin RNA (shRNA) did not exhibit changes in cell viability or cell cycle distribution assays following exposure to 0.1?Gy of γ-radiation. However, microRNA (miRNA) microarrays revealed that a lack of BMI1 leads to changes in miRNA expression in response to LDR. Bioinformatics analyses demonstrated that predicted target genes of the altered miRNAs are functionally involved in both negative and positive regulation of cell growth, cell proliferation, cell cycle and apoptosis. Therefore, these results indicate that low radiosensitivity even in the absence of the radioresistant factor BMI1 is related with the altered miRNA expression profiles in NHDF.</P>
Bae, Seunghee,Ha, Tae-Su,Yoon, Youngmin,Lee, Joonyoung,Cha, Hwa Jun,Yoo, Hoesook,Choe, Tae-Boo,Li, Shunhua,Sohn, Insook,Kim, Ji-Young,Kim, Cha-Soon,Jin, Hyeon-Ok,Lee, Hyung-Chahn,Park, In-Chul,Kim, Ch D.A. Spandidos 2008 International journal of molecular medicine Vol.21 No.3
<P>Apoptosis executed by the mammalian caspase family plays a fundamental role in cellular homeostasis. Deregulation of this process is associated with several human diseases. The multimerization of ligand-induced death receptors results in the recruitment of the death inducing signaling complex and autocatalytic activation of initiator caspases, including caspase-8 and -10. However, it is still unclear how initiator caspases trigger and control the early apoptotic signaling pathways, partly because the downstream proteolytic cleavage targets of the initiator caspases are not completely known. Although it is known that a number of proteins are cleaved by various members of the caspase family, the identification of specific cleavage substrates of the initiator caspases 8 and 10, has been hindered by a lack of systematic and broadly applicable strategies for substrate identification. In the present study we constructed a mouse cDNA library and used it to perform a systematic, genome-wide screen for novel in vitro substrates of caspase-8 and -10. From this, we successfully identified six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis. These findings may provide useful information for elucidating the apoptotic signaling pathways downstream of the death receptors.</P>
정승희(Seunghee Jeong),임현우(Hyeon Woo Yim),정영은(Youngeun Jung),조선진(Sunjin Jo),전태연(Taeyoun Jun),정성원(SungWon Jung),이민수(Minsoo Lee),김재민(Jaemin Kim) 한국역학회 2008 Epidemiology and Health Vol.30 No.2
Purpose: People with a family history of mood disorder are more likely to have depression. This study compared the characteristics of non-psychotic major depression disorder according to family history of depression. Method: Subjects were total of 817 persons recruited for the CRESCEND-K multicenter trial. Characteristics of depression and suicide history of patients with and without a family history of depression were assessed. Family history was determined through self-report. Results: Of 817 participants, 12.4% had a positive family history of depression. Those with family history of depression reported an earlier age at onset of MDD, and more psychiatric comorbidity. Severity of depression and anxiety were not different according to family history of depression. There were no difference in attempted suicide history, number of attempted suicide and age at onset of 1st attempted suicide according to such a family history. Conclusion: Patients with family history of depression reported earlier onset of MDD and more history of psychiatric comorbidity.
BAE, SEUNGHEE,LEE, EUN-JIN,LEE, JAE HO,PARK, IN-CHUL,LEE, SU-JAE,HAHN, HYUNG JIN,AHN, KYU JOONG,AN, SUNGKWAN,AN, IN-SOOK,CHA, HWA JUN UNKNOWN 2014 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.33 No.1
microRNAs (miRNAs) have been shown to function as primary regulators of a variety of biological processes, including proliferation, differentiation and apoptosis in human keratinocytes. However, the biological significance of miRNAs in the defense against oxidative stress in keratinocytes remains to be elucidated. In this study, we demonstrate that oridonin, a diterpenoid compound isolated from Rabdosia rubescens with established antioxidant properties, protects HaCaT human keratinocytes from oxidative stress induced by exposure to hydrogen peroxide (H2O2). Our data demonstrate that low doses of oridonin (1-5 M) protect keratinocytes against H2O2-induced apoptosis in a concentration- and time-dependent manner. Moreover, as shown by our results, oridonin markedly decreased H2O2-induced reactive oxygen species production in HaCaT cells. Oridonin mediated these effects by altering miRNA expression. Bioinformatics analysis identified several putative target genes of the differentially expressed miRNAs. Assessment of their gene ontology annotation revealed that these target genes are likely involved in cell growth and inhibition of apoptosis. Thus, the data from this study establish a role for miRNAs in mediating oridonin-induced protective effects against oxidative stress in human keratinocytes.