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Resistome Study in Aquatic Environments
( Hanseob Shin ),( Yongjin Kim ),( Seunggyun Han ),( Hor-gil Hur ) 한국미생물생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.3
Since the first discovery of antibiotics, introduction of new antibiotics has been coupled with the occurrence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). Rapid dissemination of ARB and ARGs in the aquatic environments has become a global concern. ARB and ARGs have been already disseminated in the aquatic environments via various routes. Main hosts of most of ARGs were found to belong to Gammaproteobacteria class, including clinically important potential pathogens. Transmission of ARGs also occurs by horizontal gene transfer (HGT) mechanisms between bacterial strains in the aquatic environments, resulting in ubiquity of ARGs. Thus, a few of ARGs and MGEs (e.g., strA, sul1, int1) have been suggested as indicators for global comparability of contamination level in the aquatic environments. With ARB and ARGs contamination, the occurrence of critical pathogens has been globally issued due to their widespread in the aquatic environments. Thus, active surveillance systems have been launched worldwide. In this review, we described advancement of methodologies for ARGs detection, and occurrence of ARB and ARGs and their dissemination in the aquatic environments. Even though numerous studies have been conducted for ARB and ARGs, there is still no clear strategy to tackle antibiotic resistance (AR) in the aquatic environments. At least, for consistent surveillance, a strict framework should be established for further research in the aquatic environments.
Hae Ri Lee,Seunggyun Han,Jong Yoon Lee,Gwanwon Lee,Sungho Lee,Han-Ik Joh 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Heteroatom-doped carbon catalysts are promising alternatives to platinum group metal-free catalysts foroxygen reduction reaction (ORR). To enhance the ORR activity of carbon-based catalysts, the break ofelectroneutrality and number of active sites must be maximized. In this study, an annealing process ata mild temperature was introduced before heteroatom doping to control the content and configurationof the oxygen functional groups on the graphene oxide (GO). Pre-annealing affects the chemical configurationand the porosity of GO such that the epoxy groups are converted into carbonyl groups accompanyingthe defect formation. Interestingly, The carbonyl-enriched environment allowed ammonia borane,as a dopant with nitrogen and boron atoms, the enhanced doping performance, inducing the formation ofhigher number of heteroatom doping sites and additional defects in the graphene lattice. The aBNG-150catalyst demonstrated outstanding ORR activity in both half- and single-cell evaluations because it hadthe highest heteroatom content and meso/macropores derived from the elimination of oxygen functionalgroups, which can facilitate ORR catalytic activity and O2 diffusion pathway. Therefore, we believe thatthis approach provides an effective route for synthesizing carbon-based catalysts with remarkable ORRperformances.
Autodesign을 이용한 야지주행 능동현수장치의 제어 이득 최적화 연구
손영일(Youngil Sohn),이경돈(Kyoung-Don Lee),김승균(Seunggyun Kim),한인식(In-Sik Han) 한국자동차공학회 2011 한국자동차공학회 부문종합 학술대회 Vol.2011 No.5
In this paper, in order to acquire optimized control gains for Near Constant Force Suspension(NCFS) strategy of active suspension, we use Autodesign toolkit which is included in Recurdyn software. Wheeled vehicle is modelled using Recurdyn software as a test vehicle, and NCFS control algorithm is implemented using Matlab/Simulink package. Furthermore, these two softwares are connected, which makes a co-simulation platform. Some control gains are defined as a design value in Autodesign toolkit, and vertical displacement, speed, and acceleration of the vehicle are used as a performance evaluation required to calculate the optimum values of the control gains. By selecting the method of design of experiment and meta-model, we can proceed the optimization process easily using this Autodesign toolkit, which results in a good design results which show us better control results compared with the results with manually tuned gains.