박인환 시에서의 우울과 시간의식

박슬기(Park Seul-ki) 한국시학회 2012 한국시학연구 Vol.- No.33

박인환 시에 만연한 우울과 슬픔의 감정은 허무와 죽음의식을 나타내는 것으로 평가되어 왔다. 초기 시에서 보였던 현실 지향적 의식이 전쟁을 경험하면서, 내면으로 침잠하는 페시미즘의 성향을 보이는 것으로 평가되어 왔다. 그러나 이 슬픔과 우울의 감정은 박인환의 시에서 시간의식과 밀접하게 관계되어 나타난다는 점에서, 역사적인 것으로 이해되어야 한다. 말하자면, 전쟁이라는 매우 구체적인 폭력의 현상을 목도하고 경험하는 순간에 얻어지는 감정은 이 경험의 순간을 역사적으로 고찰할 수 있는 판단력에 해당한다. 박인환의 시는 초기의 현실 지향적 경향에서 후퇴하여 내면으로 침잠한 것이라기보다는, 이 순간의 적극적인 인식을 통해서 여전히 현실에 대응할 수 있는 시의 가치를 견고하게 지켜내고자 했다고 할 수 있다. '우울'이라는 감정의 적극적 노출은 그가 페시미즘에 빠졌다는 것을 의미하는 것이 아니라, 당시에 전쟁을 대한 다른 사람들과 다른 위치에서 있었다는 것을 의미한다. 박인환의 시에서 시간은 적극적인 '현재'의 시간, '순간'의 시간이며, 이는 그러한 시간선 위에서 빠져나오는 것을 의미하기 때문이다. 박인환은 진보적 시간관에서 빠져나와 '순간'에 적극적으로 서는 것으로써 자신의 전쟁경험을 구성하고, 그것에 의미를 부여하려고 한다. '우울'은 전쟁이라는 당면한 역사적 비극 앞에서 그것을 '판단'하고 그 자리에서 '인간의 가치'를 찾아보려는 노력에 수반하여 나타났다. 비록 박인환은 요절함으로써 그 시적 성취를 끝까지 끌고 가지는 못했지만, 1950년대에 만연한 '감정'의 문제를 새로운 차원에서 바라볼 수 있는 단초를 마련하고 있다고 평가할 수는 있을 것이다. The overflowing emotions of melancholy and sorrow in Park, In-hwan's poems has been interpreted as his consciousness of the death; his keen attention toward the reality seems to have been transformed into pessimistic attitude, which turned him to the interior after he experienced the Korean war. However, in the sense that those emotions of melancholy and sorrow are in close connection with the poet's unique concept of time, we have to understand those as something with its own historicity. Park construes historical time through the moments and achieve the positive attitudes through his poetic method of recollection. He makes the past present through the recollection; what is not existent any more is associated with the present through this poetic imagination, and this allows humans to be saved from the momentary despair. The positive exposure of the melancholic emotion in his poems does not mean that he indulged himself with pessimism; it means that he took the different position toward the war from others. In his poems, time is always the time of the positive present and this unique conception allows him to break away from the general concept of the linear flow of time. Park tries to construct and reevaluate what he experienced at the war while positioning himself at the positive moments with escaping from the conceptual framework of the progressiveness of time. The melancholy is accompanied with Park's struggle to understand the historical tragedy of the war and to discover the human values at its site. Though Park's untimely death prevented him to take this poetic achievement to another level, his poetics allows us to comprehend the issue of overflowing emotions in the post-war Korean poetry from a new angle.

중합효소연쇄반응법을 이용한 급성 치수 및 치근단 질환의 병원성 세균의 동정

김지훈,유소영,임선아,국중기,임상수,박슬희,황호길 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.2

The purpose of this study was to investigate the frequency of 7 putative pathogens in endodontic infections. The specimens were collected from infected pulpal tissue of patients who were referred for root canal treatment to the department of conservative dentisty, Chosun University. Samples were collected aseptically using a barbed broach and a paper point. The cut barbed broaches and paper points were transferred to an eppendorf tube containing 500 ml of 1 X PBS. DNAs were extracted from the samples by direct DNA extraction method using lysis buffer (0.5% EDTA, 1% Triton X-100). Identification of 7 putative pathogens was performed by PCR based on 16S rDNA. The target species were as follows: Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Bacteroides forsythus, Actinobacillus actinomycetemcomitans, and Treponema denticola. Our data revealed that the prevalence of P.endodontalis was found in 88.6% (39 / 54), P.gingivalis 52.3% (23 / 44), P.nigrescens 18.2%(8 / 44), P.intermedia 15.9% (7 / 44), B.forsythus 18.2% (8 / 44), A.actinomycetemcomitans 2.3% (1 / 44), T.denticola 25% (11 / 44) of the samples. The high prevalence of P. endodontalis and P.gingivalis suggests that they may play an important role in the etiology of endodontic infections.

Optimization of Trimethylamine (TMA) Analysis Using Response Surface Method and Removal of TMA Using Microbial Treatment

Seul-Ki Park(박슬기) 한국수산과학회 양식분과 2020 한국수산과학회 양식분과 학술대회 Vol.2020 No.7

Efficacy of omalizumab in chronic refractory urticaria: Practical experiences in Korean patients

( Seul Ki Lee ),( Shin Young Song ),( Se Ha Park ),( Jeong Soo Kim ),( Hee Joo Kim ),( Jin Ok Baek ),( Hyang Joon Park ),( Joo Young Roh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: More than half of chronic spontaneous urticaria ( CSU ) patients do not respond adequately to H1-antihistamine treatment. Omalizumab is a humanized anti-IgE monoclonal antibody that has proved to be effective in treatment of patients with chronic urticaria refractory to antihistamines. Objectives: We analyzed real world experiences with using omalizumab for CSU patients who did not respond to treatment with high dose antihistamine. Methods: Twenty five patients (male : female=12 : 13, mean age, 51.0 years) were treated with 150mg or 300mg omalizumab every 4 weeks more than 12 weeks. The duration of CSU ranged 3 months and 12 years (mean, 3.3 years). Mean serum IgE level was 127.4 IU/ml (2~362 IU/ml). Treatment efficacy were assessed primarily based on Weekly urticaria activity scores (UAS-7), Weekly itch severity score (ISS-7) and Investigator’s Global assessment (IGA) changes from baseline to week 12. Results: After 12 weeks of therapy, mean UAS-7 decreased from 26.0 to 3.8, mean ISS-7 decreased from 13.5 to 2.1 and mean IGA decreased from 3.3 to 1.0. Complete remission (UAS-7 =0) was seen in 54.5% of patients who started with 300mg and in 35.7% of those who started with 150mg. Partial response (UAS-7≤6) was observed in 84.0 % of patients. Four patients(16%) had treatment failure(UAS-7>6) to omalizumab treatment. Conclusion: This real world experience demonstrated that omalizumab is a well-tolerated, beneficial option for the treatment of CSU patient refractory to antihistamine.

Effects of Cinnamomi and Ulmi Cortex on 4HNE (4-hydroxy-2-nonenal) reduction induced by DNCB (2,4-dinitrochlorobenzene)

Seul-Ki Park,Seung-Kuk Bae,Yoon-Bum Lee,Won-Yong Park,Young-Jin Lee,Do-Won Lee,Yeon-Seop Jung,Woo-Suk Koh,Mi-Jin Jang,Kil-Soo Kim 한국실험동물학회 2020 한국실험동물학회 학술발표대회 논문집 Vol.2020 No.2

Value at risk forecasting for volatility index

Park, Seul-Ki,Choi, Ji-Eun,Shin, Dong Wan Taylor Francis 2017 Applied Economics Letters Vol.24 No.21

Suppressive Effects of Benincasae hispida on Allergic Inflammation

Park, Seul-Ki,Kim, Jum-Ji,Sung, Sang-Min,Lee, Mi-Young The Korean Society of Toxicogenomics and Toxicopro 2009 Molecular & cellular toxicology Vol.5 No.4

The effects of an extract of Benincasae hispida on allergic inflammation were examined in terms of histamine and $\beta$-hexosaminidase release, serum IgE level and inflammatory cytokine level. The B. hispida extract inhibited the release of histamine and $\beta$-hexosaminidase, a degranulation marker, from rat basophilic leukemia cells (RBL-2H3). When mice were first ovalbumin-challenged and then treated with B. hispida extract, there was a significant decrease in the IgE level in the mouse serum. The extract treatment reduced the serum IgE level prominently, compared with the ovalbumin-challenged mice. The extract also significantly reduced the TNF-$\alpha$ and IL-4 levels in the BAL fluid when challenged with antigen. Taken together, the Benincasae hispida extract may be efficacious against allergic inflammation.

The reappraisal of the slide-swing skin flap: a versatile technique for surgical defects

( Seul-ki Lee ),( Min-soo Kim ),( Se-ha Park ),( Shin-young Song ),( Mihn-sook Jue ),( Joo Young Roh ),( Hee Joo Kim ),( Jin Ok Baek ),( Hyang-joon Park ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: The slide-swing skin flap is a combination of transposition and adjacent skin sliding and can be used to close large, round defects with a flap that is smaller than the primary defect to produce aesthetically good results. Objectives: To evaluate the efficacy and safety of the slide- swing skin flap for various surgical defects caused by skin tumor excisions. Methods: This retrospective case series, which includes 33 Asian patients between the ages of 25 and 86 years, describes the slide-swing skin flap after primary excision for malignant or premalignant skin conditions. The outcomes were assessed 12 weeks after surgery using the patient and observer scar assessment scale (POSAS). Results: Patients were 25 male and 8 female, and the causes of surgery were various malignant skin tumors including malignant melanoma, dermatofibrosarcoma protuberans, and malignant nodular hidradenoma. Tumors were on the lower limb in 11 patients, back in 9 patients, chest in 5 patients, face in 3 patients, buttock in 3 patients and 2 patients had tumors in other locations. The mean defect size was 3.5×3.1±1.9×2.2 cm. The mean patient POSAS total score was 9.7±3.0 and mean observer POSAS total score was 11.0±2.7. All flaps survived and postoperative recoveries were uneventful. Conclusion: The slide-swing skin flap is highly versatile and can be used to cover various surgical defects, irrespective of size and location, with excellent functional and cosmetic results.

A case of Carney complex with a cutaneous myxoma

( Seul Ki Lee ),( Shin Young Song ),( Se Ha Park ),( Hee Joo Kim ),( Hyang Joon Park ),( Joo Young Roh ),( Jin Ok Baek ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Carney Complex (CNC) is a rare autosomal dominant syndrome, characterized by multiple neoplasia, including myxomas and endocrine tumors, and schwannomas. The disease is caused by inactivating mutations or large deletions of the PRKAR1A gene. The cutaneous manifestations are a major clue in this disorder. Cutaneous myxomas are found in 30-55% of CNC patients and usually appear in the eyelid, external ear canal, breast nipples, and the genitalia. A 3-year-old female patient who was diagnosed with Carney complex presented with well-defined soft erythematous asymptomatic nodule on the scalp for a year. Histopathologic examination showed hypocellular myxoid stroma and collagenized capsule at periphery. Alcian blue stain showed intense positivity for mucin. Her mother and uncle had a carney complex, and a PRKAR1A gene mutation was also detected in her gene test. There were no other cutaneous symptoms such as pigmentation, and there were no abnormal signs on echocardiography or brain MRI. The cutaneous myxoma was first sign with no other symptoms that the carney complex could be suspected in this patient. We report a recent experience of a case of Carney complex with cutaneous myxoma and emphasize that skin manifestation can be an important clue to this disease.

Global knockdown of microRNAs affects the expression of growth factors and cytokines in human adipose-derived mesenchymal stem cells

( Seul Ki Park ),( Jung Shin Lee ),( Eun Kyung Choi ),( Dalsan You ),( Choung Soo Kim ),( Na Young Suh ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.8

Cell therapies utilizing mesenchymal stem cells (MSCs) have agreat potential in many research and clinical settings. Themechanisms underlying the therapeutic effects of MSCs havebeen studied previously and the paracrine effects elicited bytheir production of various growth factors and cytokines wererecognized as being crucial. However, the molecular controlsthat govern these paracrine effects remain poorly understood. To elucidate the molecular regulators of this process, weperformed a global knockdown of microRNAs (miRNAs) inhuman adipose-derived mesenchymal stem cells (hADSCs) byinhibiting DGCR8, a key protein in miRNA biogenesis. Globaldisruption of miRNA biogenesis in hADSCs caused dramaticchanges in the expression of subsets of growth factors andcytokines. By performing an extensive bio in formatic an alysis, we were able to associate numerous putative mi RNAs with these genes. Taken together, our results strongly suggest thatmiRNAs are essential for the production of growth factors and cytokines in hADSCs.