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Lee, Young-Mi,Seiichi Hirota,Tomoko Jippo-Kanemoto,Kim, Hyung-Ryong,Shin, Tae-Yong,Yeom, Young-il,Lee, Kyung-Kwang,Yukihiko Kitamura,Shintaro Nomura,Kim, Hyung-Min 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-
The effect of glycyrrhetinic acid (18-O-B-glycyrrhetinic acid, GA) on histamine metabolism was investigated in cultured mast cells (CMCs) cocultured with Swiss 3T3 fibroblasts. GA strongly inhibited histamine synthesis in the cocultured CMCs. Since 50 uM GA inhibited about 80% of histidine decarboxylase (HDC) activity, the inhibitory activity of GA for histamine synthesis was considecred to be derived from the inhibition of HDC activity. The number of berberine-sulfate-positive cells also decreased in the presence of GA, which indicated that maturation of CMCs was inhibited by GA. Furthermore, we examined the efect of GA on the mRNA expression of novel protein kinase C??(nPKC??), a major isoform of CMCs, by Northern blot analysis. The expression of nPKC?? mRNA in the presence of GA was significantly lower than in the absence of GA. These results suggest the possibility that the inhibition of histamine syntesis by GA is regulatd by nPKC??.
Asian Consensus Guidelines for the Diagnosis and Management of Gastrointestinal Stromal Tumor
구동회,류민희,김경미,양한광,Akira Sawaki,Seiichi Hirota,Jie Zheng,Bo Zhang,Chin-Yuan Tzen,Chun-Nan Yeh,Toshirou Nishida,Lin Shen,Li-Tzong Chen,강윤구 대한암학회 2016 Cancer Research and Treatment Vol.48 No.4
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors originating in the gastrointestinal tract. With the introduction of molecular-targeted therapy for GISTs which has yielded remarkable outcomes, these tumors have become a model of multidisciplinary oncological treatment. Although Western clinical guidelines are available for GISTs, such as those published by the National Comprehensive Cancer Network (NCCN) and the European Society of Medical Oncology (ESMO), the clinical situations in Asian countries are different from those in Western countries in terms of diagnostic methods, surgical approach, and availability of new targeted agents. Accordingly, we have reviewed current versions of several GIST guidelines published by Asian countries (Japan, Korea, China, and Taiwan) and the NCCN and ESMO and discussed the areas of dissensus. We here present the first version of the Asian GIST consensus guidelines that were prepared through a series of meetings involving multidisciplinary experts in the four countries. These guidelines provide an optimal approach to the diagnosis and management of GIST patients in Asian countries.