Drug adsorption and anti-microbial activity of functionalized multiwalled carbon nanotubes

Saxena, Megha,Mittal, Disha,Boudh, Richa,Kumar, Kapinder,Verma, Anita K.,Saxena, Reena Techno-Press 2021 Advances in nano research Vol.11 No.6

Multiwalled carbon nanotubes (MWCNTs) were first oxidized (O-CNTs) to introduce carboxylic group and then further functionalized (F-CNTs) with m-phenylenediamine, which was confirmed by FTIR and SEM. It was used as an effective adsorbent for the adsorptive removal of diclofenac drug from water. Under optimum conditions of pH 6, stirring speed 600 rpm, the maximum adsorption capacity obtained was 532 mg g^-1 which is superior to the values reported in literature. The adsorption was quite rapid as 25 mg L^-1 drug solution was adsorbed in only 3 minutes of contact time with 10 mg of adsorbent dose. The adsorption kinetics and isotherms were studied using various models to evaluate the adsorption process. The results showed that the data best fit in kinetics pseudo-second order and Langmuir isotherm model. Furthermore, the oxidized and functionalized MWCNTs were applied on gram-negative Escherichia coli and gram-positive Staphylococcus aureus using agar disc diffusion assay to validate their anti-microbial activity. Results were unique as both oxidized and functionalized MWCNTs were equally active against both E. coli and S. aureus. The newly synthesized F-CNTs have great potential in water treatment, with their dual action of removing drug and pathogens from water, makes it potential applicant to save environment.

Systematic review of the effectiveness of homoeopathy in the treatment of autism spectrum disorder

Vibha Saxena,Gish Chacko,Udit Saxena 한국언어재활사협회 2021 Clinical Archives of Communication Disorders Vol.6 No.1

Purpose: Over the years there is a significant increase in Autism Spectrum Disorder (ASD), yet there is no standard medical treatment available for this population. Homoeopathy as reported in literature can prove to be a boon for ASD treatment as in homoeopathy patients are prescribed medicine based on specific symptoms in light of associated physical and mental aspect. A systematic review of literature was required to put together the reported information on the relation between homoeopathy and ASD. This work reviews all the related literature in-depth. Methods: Literature on the concerned issue was searched from databases like Scopus, PubMed, ScienceDirect, JASTOR, Google Scholar, PsycINFO (psychology and psychiatry literature), and ERIC (Education Resources Information Center). Results: In total, 19 published articles were found on the investigation of using homoeopathy in the treatment of ASD. Seventeen studies showed that homoeopathy can be effective in the treatment of ASD. Result of 1 study was inconclusive and 1 more study found homoeopathy to be not suitable in treating ASD. Conclusions: Most reports support the use of homoeopathy in the treatment of ASD. They describe that homoeopathy efficiently control ASD symptoms and also supplements other therapies used in the treatment of ASD. Few authors suggested otherwise too.

Polycrystalline Silicon Thin-Film Transistor Using Xe Flash-Lamp Annealing

Saxena, Saurabh,Dong Cheol Kim,Jeang Hun Park,Jin Jang IEEE 2010 IEEE electron device letters Vol.31 No.11

<P>We report a high-performance thin-film transistor (TFT) using polycrystalline silicon (poly-Si) by short-pulse Flash-lamp annealing of amorphous silicon. Large grains of average size of ~15 μm with wide branchlike grain boundaries were found in the poly-Si, and there was no amorphous phase inside. The fabricated p-channel poly-Si TFT on the grain exhibited field-effect mobility of 138 cm<SUP>2</SUP>/V · sec, a threshold voltage of -1.3 V, and an on/off current ratio of 10<SUP>8</SUP>.</P>

Chronic persistent post-surgical pain following staging laparotomy for carcinoma of ovary and its relationship to signal transduction genes

Saxena, Ashok Kumar,Chilkoti, Geetanjali T,Chopra, Anand K,Banerjee, Basu Dev,Sharma, Tusha The Korean Pain Society 2016 The Korean Journal of Pain Vol.29 No.4

Background: The present study was undertaken to evaluate the incidence of chronic persistent post-surgical pain (CPPP) and the role of signal transduction genes in patients undergoing staging laparotomy for carcinoma ovary. Methods: The present observational study was undertaken following institutional ethical committee approval and informed consent from all the participants. A total 21 patients of ASA grade I to III with age 20-70 years, scheduled for elective staging laparotomy for carcinoma ovary were included. Patients were excluded if had other causes of pain, cognitive dysfunction or chronic neurological disorders. Statistical analysis of pool data was done using SPSS version-17. For various scales like GPE, PDQ, NPSI, the visual analogue scale (VAS), global perceived effect (GPE), the pain DETECT questionnaire (PDQ), and neuropathic pain symptoms inventory (NPSI), one factor repaeted measure ANOVA applied with simple contrast with baseline as on post-operative day 1 (considered as reference and compared with subsequent time-interval), and the P values were adjusted according to "Bonferroni adjustments". In patients with CPPP, the ${\Delta}ct$ values of mRNA expressions of genes at the end of postoperative day 90 were compared with the baseline control values by one factor repeated ANOVA. P value < 0.005 significant. Results: The present study demonstrates 38.1% (8 out of 21 patients) incidence of CPPP. The functional status and quality of life as were observed to be significantly diminished in all patients with chronic pain. An up-regulation in the mRNA expression of signal transduction and a positive correlation was noted between the mRNA expression of signal transduction genes and VAS score in all patients with CPPP at the end of postoperative day 90. Conclusions: The reported incidence of CPPP in patients with carcinoma ovary was 38.1%. An up-regulation and positive correlation between mRNA expression of signal transduction genes and VAS score depicts its potential role in the pathogenesis of CPPP.

LOWER FORMATION RADICAL FOR NEAR RINGS

Saxena, P.K.,Bhandari, M.C. Department of Mathematics 1978 Kyungpook mathematical journal Vol.18 No.1

In [7) Scott has defined C-formation radical for a class C of near rings and has studied its porperties under chain conditions. A natural question that arises is: Does there exist a Lower C-Formation radical class L(M) containing a given class M of ideals of near rings in C? In this paper we answer this by giving. two constructions for L(M) and prove that prime radical is hereditary.

ON THE H-FUNCTION OF n-VARIABLES

Saxena, R.K. Department of Mathematics 1977 Kyungpook mathematical journal Vol.17 No.2

ON THE H-FUNCTION OF n-VARIABLES II

Saxena, R.K. Department of Mathematics 1980 Kyungpook mathematical journal Vol.20 No.2

THE HYPOTHALAMIC PITUITARY GONADAL AXIS IN THYROTOXICOSIS : THE EFFECT OF LUTEINIZING HORMONE RELEASING HORMONE

Saxena, Sulakshna,Pascasio, Flora N.,Manipol, Vicitacion 대한핵의학회 1984 핵의학 분자영상 Vol.18 No.1

Authentication and Authorization Scheme for Various User Roles and Devices in Smart Grid

Saxena, Neetesh,Bong Jun Choi,Rongxing Lu IEEE 2016 IEEE transactions on information forensics and sec Vol.11 No.5

<P>The smart grid, as the next generation of the power grid, is characterized by employing many different types of intelligent devices, such as intelligent electronic devices located at substations, smart meters positioned in the home area network, and outdoor field equipment deployed in the fields. In addition, there are various users in the smart grid network, including customers, operators, maintenance personnel, and so on, who use these devices for various purposes. Therefore, a secure and efficient mutual authentication and authorization scheme is needed in the smart grid to prevent various insider and outsider attacks on many different devices. In this paper, we propose an authentication and authorization scheme for mitigating outsider and insider threats in the smart grid by verifying the user authorization and performing the user authentication together whenever a user accesses the devices. The proposed scheme computes each user role dynamically using an attribute-based access control and verifies the identity of the user together with the device. Security and performance analysis show that the proposed scheme resists various insider as well as outsider attacks, and is more efficient in terms of communication and computation costs in comparison with the existing schemes. The correctness of the proposed scheme is also proved using BAN-Logic and Proverif.</P>

LOWER AND UPPER FORMATION RADICAL OF NEAR-RINGS

Saxena, P.K.,Bhandari, M.C. Department of Mathematics 1979 Kyungpook mathematical journal Vol.19 No.2

In this paper we continue the study of formation radical (F-radical) classes initiated in [3]. Hereditary and stronger properties of F-radical classes are discussed by giving construction for lower hereditary, lower stronger and lower strongly hereditary F-radical classes containing a given class M. It is shown that the Baer F-radical B is the lower strongly hereditary F-radical class containing the class of all nilpotent ideals and it is the upper radical class with $\{(I,\;N){\mid}N{\in}C,\;N\;is\;prime\}{\subset}SB$ where SB denotes the semisimple F-radical class of B and C is an arbitrary but fixed class of homomorphically closed near-rings. The existence of a largest F-radical class contained in a given class is examined using the concept of complementary F-radical introduced by Scott [5].