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Biomarker detection technologies and future directions
Nimse, Satish Balasaheb,Sonawane, Mukesh Digambar,Song, Keum-Soo,Kim, Taisun The Royal Society of Chemistry 2016 The Analyst Vol.141 No.3
<P>Biomarkers play a vital role in disease detection and treatment follow-up. It is important to note that diseases in the early stage are typically treated with the greatest probability of success. However, due to various technical difficulties in current technologies for the detection of biomarkers, the potential of biomarkers is not explored completely. Therefore, the developments of technologies, which can enable the accurate detection of prostate cancer at an early stage with simple, experimental protocols are highly inevitable. This critical review evaluates the current methods and technologies used in the detection of biomarkers. The aim of this article is to provide a comprehensive review covering the advantages and disadvantages of the biomarker detection methods. Future directions for the development of technologies to achieve highly selective and sensitive detection of biomarkers for point-of-care applications are also commented on.</P>
Nimse, Satish Balasaheb,Song, Keum-Soo,Kim, Junghoon,Sayyed, Danishmalik Rafiq,Kim, Taisun Molecular Diversity Preservation International (MD 2013 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.14 No.3
<P>A 9G DNAChip obtained by allowing the formation of a self-assembled monolayer (SAM) of oligonucleotides appended with nine consecutive guanines on the chip surface has been applied in the detection of biomarkers. Using a 9G DNAChip, biomarker in the concentration range of 4 pg/mL to 40 fg/mL can be easily differentiated in the buffer matrix. Moreover, it is the first time that a biomarker with a concentration of 40 fg/mL has been detected in a mixture of proteins without use of any signal amplification technique.</P>
Synthesis and Modification of Novel Iminecalix[4]arene Derivatives
Satish Balasaheb Nimse,Junbae Kim,Keum-Soo Song,Junghoon Kim,이정태,Van-Thao Ta,Van-Thuan Nguyen,김태선 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
The synthesis of novel iminecalix[4]arenes and further modification thereafter is described using a synthetic strategy. The reaction of the benzaldehyde derivatives with tetraamine functions on the calix[4]arene easily afforded the pure compounds in 92.4-95.7% yields, regardless of the effect of the substituents on the benzaldehyde derivatives. These compounds were stable under the conditions to obtain their analogue dialkylated in the narrow rim, with 83.2-89.9% yields. Characterization of the newly synthesized iminecalix[4]arene derivatives by spectroscopic methods revealed that all compounds are in the cone conformations.
Molecular Recognition of Neutral Substrates by New Tetraaminocalix[4]arene Derivative
Satish Balasaheb Nimse,Keum-Soo Song,Chan-Yong Jung,Woon-Yong Eoum,김태선 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.6
The recognition of neutral aromatic substrates by different neutral calix[4]arene receptors 1, 2, and 3 was studied by NMR spectroscopy. The stoichiometry is 1:1 in all cases as was confirmed by jobs plot. Owing to the deep cavity, 1 affords stronger binding abilities for substrate 4 and 5, while all receptors remained inert for substrates 6 and 7. The binding constants determined by 1H NMR titration show that the recognition of substrate 4 by 1 gives strongest complexation (Ka of 9.8 × 102 M-1).
Biological applications of functionalized calixarenes
Nimse, Satish Balasaheb,Kim, Taisun The Royal Society of Chemistry 2013 Chemical Society reviews Vol.42 No.1
<P>The functionalized calixarene derivatives exhibit remarkable properties towards organic and bioorganic molecules. However, the ability of calixarene derivatives to form stable complexes with biomolecules allows them to be applied for the development of biosensors and in the field of biology, biotechnology, and drug discovery. The applications of the functionalized calixarenes are summarized in this review, and an outlook for the future developments is discussed. A brief survey (of the last 10 years) on their biological application in various fields is also considered (199 references).</P> <P>Graphic Abstract</P><P>The applications of functionalized calixarenes are summarized in this Review, and an outlook for the future developments is discussed. A brief survey (of the last 10 years) on their biological application in various fields is also considered. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cs35233h'> </P>
Molecular Recognition of Neutral Substrates by New Tetraaminocalix[4]arene Derivative
Nimse, Satish Balasaheb,Song, Keum-Soo,Jung, Chan-Yong,Eoum, Woon-Yong,Kim, Tai-Sun Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.6
The recognition of neutral aromatic substrates by different neutral calix[4]arene receptors 1, 2, and 3 was studied by NMR spectroscopy. The stoichiometry is 1:1 in all cases as was confirmed by jobs plot. Owing to the deep cavity, 1 affords stronger binding abilities for substrate 4 and 5, while all receptors remained inert for substrates 6 and 7. The binding constants determined by $^1H$ NMR titration show that the recognition of substrate 4 by 1 gives strongest complexation ($K_a\;of\;9.8\;{\times}\;102\;M^{-1}$).
Synthesis and Modification of Novel Iminecalix[4]arene Derivatives
Nimse, Satish Balasaheb,Kim, Jun-Bae,Lee, Jeong-Tae,Song, Keum-Soo,Kim, Jung-Hoon,Ta, Van-Thao,Nguyen, Van-Thuan,Kim, Tai-Sun Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
The synthesis of novel iminecalix[4]arenes and further modification thereafter is described using a synthetic strategy. The reaction of the benzaldehyde derivatives with tetraamine functions on the calix[4]arene easily afforded the pure compounds in 92.4-95.7% yields, regardless of the effect of the substituents on the benzaldehyde derivatives. These compounds were stable under the conditions to obtain their analogue dialkylated in the narrow rim, with 83.2-89.9% yields. Characterization of the newly synthesized iminecalix[4]arene derivatives by spectroscopic methods revealed that all compounds are in the cone conformations.
A glass fibre membrane platform for ultra-sensitive detection of cardiac troponin T
Song, Keum-Soo,Nimse, Satish Balasaheb,Sonawane, Mukesh Digambar,Lin, Yahui,Zhou,Kim, Taisun The Royal Society of Chemistry 2017 The Analyst Vol.142 No.20
<P>A glass fibre membrane platform that allows quantification of circulating cTnT with a LoD of 0.87 pg mL<SUP>−1</SUP> is described. The proposed platform uses a glass fibre membrane, DNA-guided detection method, and antibody-conjugated fluorescent beads for the quantification of cTnT in the analytical detection range of 1-120 pg mL<SUP>−1</SUP> at room temperature in 30 min. Glass fibre membranes were chemically modified to immobilize the oligonucleotide probes that catch a biomolecular complex (FB-dAB-cTnT-cAB-DNA) containing complementary oligonucleotides. There were no interferences from human cTnI, cTnC, skTnT, biotin, and hemoglobin (each 1 μg mL<SUP>−1</SUP>). The linearity in the serial dilution test of plasma samples indicates that this platform is highly applicable for regular health check-up to assess the risk of AMI and HF.</P>
A new platform for a convenient genotyping system
Song, Keum-Soo,Nimse, Satish Balasaheb,Kim, Junghoon,Sayyed, Danishmalik Rafiq,Kim, Taisun The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.26
<P>The high SNP discrimination ratio of 360 : 1, 100% target-specific hybridization at 25 °C, detection limit of 10<SUP>1</SUP> copies, and differentiation of 10<SUP>1</SUP> to 10<SUP>7</SUP> copies of the PCR product of high-risk HPV genotypes in clinical samples ensure the application of the 9G membrane in a convenient platform for DNA genotyping.</P> <P>Graphic Abstract</P><P>The high SNP discrimination ratio of 360 : 1, 100% target-specific hybridization at 25 °C, detection limit of 10<SUP>1</SUP> copies, and differentiation of 10<SUP>1</SUP> to 10<SUP>7</SUP> copies of the PCR product of high-risk HPV genotypes in clinical samples ensure the application of the 9G membrane in the point-of-care DNA genotyping. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc39231g'> </P>