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Evaluation and Characterization of Fluroquinone Antibiotic loaded in to Polymeric Nanofibers.
Arthanari Saravanakumar(아따나리 사라바나 쿠멀),Mani Ganesh(마니가니쉬),Jun Ho Jang(장준호),Je O Choi(최제오),Yun Ho Cho(조윤호),Jung Ho Lee(이정호),Seung Eun Cha(차성은),Han Seok Oh(오한석),Deok Han Kwon(권덕한),장현태 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.2014 No.2
The aim of this study was to develop novel biomedicated electrospun nanofiber for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate(2 wt.%) (SA)/polyvinyl alcohol(10 wt.%) (PVA) (2:8, 3:7 and 1:9) composites by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy. The optimum ratio(3:7) was used for loading of gatifloxacin hydrochloride (GH) (1wt.%), found to form smooth fibers with uniform structures. The drug entrapment, in the composite nanofibers was confirmed by scanning electron microscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA),differential scanning calorimetry (DSC) and swelling behavior. The drug release behavior was investigated by using phosphate buffered saline (PBS) (pH 7.4) at 37°C for 24hrs. XRD and FT-IR data demonstrates that there are good interactions between PVA and SA caused by possibly hydrogen bonds. As much as 90 % of the GH was released from the electrospun fibers within 6hrs of incubation, beyond this the release was sustained for 24hrs. The thickness of nanofibers greatly influenced the initial release and rate of drug release. Moreover, GH loaded sodium alginate / PVA composite nanofibers exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications.
Saravanakumar, Arthanari,Ganesh, Mani,Jayaprakash, Jayabalan,Jang, Hyun Tae Elsevier 2015 Journal of industrial and engineering chemistry Vol.28 No.-
<P><B>Abstract</B></P> <P>A single step green synthesis of silver nanoparticles (AgNPs) from silver nitrate (AgNO<SUB>3</SUB>) using <I>Cassia tora</I> leaves extract as reducing agent by a simple and ecofriendly method in room temperature. The biosynthesized nanoparticles were characterized by UV-Vis, Scanning electron microscopy (SEM) coupled with X-ray energy dispersive spectrophotometer (EDAX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). In UV-Vis spectroscopy results, the <I>λ</I> <SUB>max</SUB> observed at 425nm. The AgNPs synthesized were spherical, hexagonal and irregular in shapes. The EDAX and XRD spectrum confirms that the presence of silver ions and crystalline nature of synthesized AgNPs. FTIR showed the functional groups such as CO, NH and CN groups involved in the reduction of Ag<SUP>+</SUP> to Ag. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay was performed and it showed percentage inhibition in concentration dependent manner. The synthesized AgNPs showed antibacterial activity against <I>Escherichia coli</I>, <I>Pseudomonas aeruginosa</I>, <I>Staphylococcus aureus</I> and <I>Bacillus subtilis</I> in different extents and the higher activity was observed in <I>Escherichia coli</I>.</P>
Arthanari Saravanakumar(아따나리 사라바나 쿠멀),Mani Ganesh(마니 가니쉬),Mei Mei Peng(펭메이메이),Abidov Sh Aziz(아비도프아지즈),Hyun Tae Jang(장현태) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.2014 No.2
Antioxidant, antimycobacterial activity of opuntia ficus-indica fruit (OFI) extracts were evaluated according to seasonable cultivation. The antioxidant activities of OFI extracts were assessed by different in vitro methods and the total phenolic and flavonoid contents were also examined. The antimycobacterial activity was measured against Mycobacterium tuberculosis strains H37Rv (ATCC 27294) by microplate alamar blue assay (MABA) method. In antioxidant assay, methanol extracts of OFI in summer season showed the highest antioxidant activity in all tested methods and the lowest IC50wasobservedin2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Pearson correlation coefficient was evaluated and the results from the extracts of summer and rainy season OFI were significantly correlated with the total phenolic and flavonoid contents. However, the methanol extracts of OFI in summer showed high level of antimycobacterial activity against the strain of M. tuberculosis H37Rv, with minimum inhibitory concentration (MIC) of 50 µg/ml. The results from this study suggest that OFI could probably be an important source of antioxidant as well as antimycobacterial against M. tuberculosis.
Arthanari Saravanakumar,장현태,Mani Ganesh,Jayabalan Jayaprakash 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.28 No.-
A single step green synthesis of silver nanoparticles (AgNPs) from silver nitrate (AgNO3) using Cassia toraleaves extract as reducing agent by a simple and ecofriendly method in room temperature. Thebiosynthesized nanoparticles were characterized by UV-Vis, Scanning electron microscopy (SEM)coupled with X-ray energy dispersive spectrophotometer (EDAX), X-ray diffraction (XRD) and Fouriertransform infrared spectroscopy (FTIR). In UV-Vis spectroscopy results, the lmax observed at 425 nm. TheAgNPs synthesized were spherical, hexagonal and irregular in shapes. The EDAX and XRD spectrumconfirms that the presence of silver ions and crystalline nature of synthesized AgNPs. FTIR showed thefunctional groups such as C55O, N–H and C–N groups involved in the reduction of Ag+ to Ag. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay was performed and it showed percentageinhibition in concentration dependent manner. The synthesized AgNPs showed antibacterial activityagainst Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis in differentextents and the higher activity was observed in Escherichia coli.
Saravanakumar Arthanari,Ponnusamy Renukadevi,Vanitha Saravanakumar 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
The utility of both in vitro and in vivo methods to assess the release pattern of alginate, HPMC (TTAL) composite microspheres containing stabilized tetanus toxoid (TT) vaccine were evaluated. TT was stabilized with different concentrations of stabilizer, lactose (1–5%, w/v) and encapsulated into alginate, HPMC composite microspheres by W/O/W multiple emulsion method. The morphology of the prepared microspheres was smooth and spherical in shape with a diameter of around 10 mm. The in vitro release efficiency of microspheres was evaluated for the period of 70 days. In TTAL microspheres, 4% (w/v) lactose gave good sustained antigen delivery for the period of 70 days. Antigen releases from microspheres were determined by ELISA. Based on the results of in vitro release, the ideal batch of TTAL was used to carry out the in vivo studies by antibody induction method using alum adsorbed tetanus toxoid (CRIT) as standard. The antibody level was measured for about of 9 months and finally with one booster dose after 12 months. In this case, TTAL antibody level was rose up to 3 IU/ml of guinea pig serum and 2.5 IU/ml of guinea pig serum was observed in CRIT after 1 year with second booster dose. This novel approach would be helpful to replace the existing adjuvant alum in future.
Mani Ganesh,Abidov Sch Aziz,Udumansha Ubaidulla,Pushparaj Hemalatha,Arthanari Saravanakumar,Rramaswamy Ravikumar,Mei Mei Peng,최은영,장현태 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.39 No.-
Novel silver nanoparticles-decorated chitosan (CS)-polyvinyl alcohol (PVA) composite electrospunnanofibers, loaded with sulfanilamide for enhanced wound healing have been developed. Herein, formicacid was used as a reducing agent to produce in situ colloidal silver nanoparticles (AgNPs) in thecomposite polymeric solution with the active agent sulfanilamide. The prepared electrospun fiberswere characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM),X-ray diffraction, ultraviolet spectroscopy, and thermal gravimetric analysis (TG). Further, in vitrorelease, antimicrobial properties and in vivo wound healing activity were evaluated. The results revealedthat the composite fibers displayed a synergistic antibacterial and wound healing activities.