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Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
Lim, Jae-Heon,Cho, Woon-Su,Park, Jang-Sung 대한물리치료학회 2015 대한물리치료학회지 Vol.27 No.5
Purpose: The study was to determine whether mechanical horseback-riding training according to velocity may improve trunk muscles thickness in healthy adults. Methods: Twenty healthy adults participated in this study. The subjects were divided into 2 groups as follows: 10 subjects in high velocity mechanical horseback-riding training (MHRT) and 10 subjects in low velocity MHRT. Subjects in all groups performed a total of 18 sessions 3 times a day for 20 minutes and this experiment lasted for 6 weeks. Mann-Whitney and Wilcoxon Signed Rank test were used in analysis the results of trunk muscle thickness. Ultrasonography was performed to evaluate for thickness of rectus abdominis (RA), external oblique (EO), internal oblique (IO), transverse abdominis (TrA), erector spine (ES), and multifidus (MF) in trunk muscles. Results: Results on the changes of EO, IO, and ES of high velocity MHRT showed a significant increase after 6 weeks (p<0.05). Regarding the changes of EO, IO, ES, TrA, and MF of low velocity MHRT, a significant increase was observed after 6 weeks (p<0.05). The differences in change of trunk muscle thickness before training, after 6-week training between groups, TrA and MF of low velocity MHRT were significantly higher (p<0.05). Conclusion: Based on the results of the current study, the velocity of MHRT was shown to affect change of trunk muscle thickness in healthy adults. In particular, low velocity MHRT may serve as a useful method to provide for TrA, MF thickness improvement related to trunk stabilizers.
Sang-Heon Lim,Choon-Man Lee,Won Jee Chung 한국정밀공학회 2006 International Journal of Precision Engineering and Vol.7 No.1
Cutting by a high speed laser cutting machine is one of most effective technologies to improve productivity. This paper has presented the cutting characteristics and optimal cutting conditions in a high speed feeding type laser cutting machine by using Tacuchi method in the design of experiment. An 1.9(34) orthogonal array is adopted to study the effect of adjustment parameters. The adjustment parameters consist of cutting speed, laser power, laser output duty and assistant gas pressure. The surface roughness of sheet metal is regarded as a quality feature. Analysis of variance is performed in order to evaluate the effect of adjustment parameters on the quality feature of laser cutting process.
Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility
Sung, Hui-Jin,Ok, Seong-Ho,Sohn, Jin-Young,Son, Yong Hyeok,Kim, Jun Kyu,Lee, Soo Hee,Han, Jeong Yeol,Lim, Dong Hoon,Shin, Il-Woo,Lee, Heon-Keun,Chung, Young-Kyun,Choi, Mun-Jeoung,Sohn, Ju-Tae Hindawi Publishing Corporation 2012 Journal of biomedicine & biotechnology Vol.2012 No.-
<P>Aminoamide local anesthetics induce vasoconstriction <I>in vivo</I> and <I>in vitro</I>. The goals of this <I>in vitro</I> study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contraction. Cumulative concentration-response curves to local anesthetics (levobupivacaine, ropivacaine, lidocaine, and mepivacaine) were obtained from isolated rat aorta. Regression analyses were performed to determine the relationship between the reported physicochemical properties of local anesthetics and the local anesthetic concentration that produced 50% (ED<SUB>50</SUB>) of the local anesthetic-induced maximum vasoconstriction. We determined the order of potency (ED<SUB>50</SUB>) of vasoconstriction among local anesthetics to be levobupivacaine > ropivacaine > lidocaine > mepivacaine. The relative importance of the independent variables that affect the vasoconstriction potency is octanol/buffer partition coefficient > potency > pKa > molecular weight. The ED<SUB>50</SUB> in endothelium-denuded aorta negatively correlated with the octanol/buffer partition coefficient of local anesthetics (<I>r</I><SUP>2</SUP> = 0.9563; <I>P</I> < 0.001). The potency of the vasoconstriction in the endothelium-denuded aorta induced by local anesthetics is determined primarily by lipid solubility and, in part, by other physicochemical properties including potency and pKa.</P>
Performance Analysis of a Vector DLL Based GPS Receiver
Lim, Deok Won,Choi, Heon Ho,Lee, Sang Jeong,Heo, Moon Beom The Institute of Positioning 2012 Journal of Positioning, Navigation, and Timing Vol.1 No.1
For a Global Positioning System (GPS) receiver, it is known that a Vector Delay Locked Loop (DLL) in which the code signals of each satellite are tracked in parallel by using navigation results shows better performance in the aspect of the tracking accuracy and the robustness than that of a Scalar DLL. However, the quantitative analysis and the logical grounds for that performance enhancement of the Vector DLL are not sufficient. This paper, therefore, proposes the structure of the GPS receiver with the Vector DLL and analyzes the performance of it. The tracking and the positioning accuracy of the Vector DLL are theoretically analyzed and confirmed by simulation results. From the simulation results, it can be seen that the tracking and positioning accuracy has been improved about 30% in case that the receiver is static and the positioning is conducted for every Pre-detection Integration Time (PIT) while C/N0 is 45 dB-Hz.
Lim Sang-Heon,Lee Choon-Man,Chung Won Jee Korean Society for Precision Engineering 2006 International Journal of Precision Engineering and Vol.7 No.1
Cutting by a high speed laser cutting machine is one of most effective technologies to improve productivity. This paper has presented the cutting characteristics and optimal cutting conditions in a high speed feeding type laser cutting machine by using Tacuchi method in the design of experiment. An L9(34) orthogonal array is adopted to study the effect of adjustment parameters. The adjustment parameters consist of cutting speed, laser power, laser output duty and assistant gas pressure. The surface roughness of sheet metal is regarded as a quality feature. Analysis of variance is performed in order to evaluate the effect of adjustment parameters on the quality feature of laser cutting process.
Effects of Streptomyces griseofuscus 200401 on Melon Powdery Mildew in Greenhouse
Lim, Tae-Heon,Cho, Jeong-Sang,Kang, Sang-Jae,Johnson, Iruthayasamy,Cha, Byeong-Jin,Choi, Yong-Hwa The Korean Society of Plant Pathology 2008 Plant Pathology Journal Vol.24 No.1
The fermentation broth (FB) of Streptomyces griseofuscus 200401 isolated from non-farming soil showed antagonistic activity against powdery mildew fungus both in melon leaf/seedling assay and in field trials. The FB of S. griseofuscus 200401 was tested at different concentrations. In primary test, the control value of 2-fold diluted FB of S. griseofuscus 200401, compared to control, reached to 82.8%. The protective activity recorded 80.5% in 2-fold dilution of FB. The effect was reduced to 28.9% in high dilution (100-fold) treatment. The curative effect was relatively lower than protective activity. In field test, the antifungal activities of S. griseofuscus 200401 remained low in blocks sprayed with 100-fold diluted FB and the control values were 15.2 and 15.9% in 2005 and 2006, respectively. However, the activities were as high as 65% and 67.3% in the blocks treated with 2-fold dilution of FB during the same period.
Multicriteria Optimization of Spindle Units
Sang Heon Lim,Choon Man Lee,Igor Aexeevich Zverev 한국정밀공학회 2006 International Journal of Precision Engineering and Vol.7 No.4
The quality of precision spindle units (S/Us) running on rolling bearings depends strongly on their structural parameters, such as the configuration and geometry of the S/U elements and bearing preloads. When S/Us are designed, their parameters should be optimized to improve the performance characteristics. However, it is practically impossible to state perfectly a general criterion function for S/U quality. Therefore, we propose to use a multicriteria optimization based on the parameter space investigation (PSI) method. We demonstrate the efficiency of the proposed method using the optimization results of high-speed S/Us.
Sang-Heon Cho,Jung-Hee Lee,Hyeong-Seok Lim,Kyoo-Hyung Lee,Dae-Young Kim,Sangmin Choe,Kyun-Seop Bae,Je-Hwan Lee 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.3
The objective of this study was to externally validate a new dosing scheme for busulfan. Thirty-seven adult patients who received busulfan as conditioning therapy for hematopoietic stem cell transplantation (HCT) participated in this prospective study. Patients were randomized to receive intravenous busulfan, either as the conventional dosage (3.2 mg/kg daily) or according to the new dosing scheme based on their actual body weight (ABW) (23×ABW<sup>0.5</sup> mg daily) targeting an area under the concentration-time curve (AUC) of 5924 μM∙min. Pharmacokinetic profiles were collected using a limited sampling strategy by randomly selecting 2 time points at 3.5, 5, 6, 7 or 22 hours after starting busulfan administration. Using an established population pharmacokinetic model with NONMEM software, busulfan concentrations at the available blood sampling times were predicted from dosage history and demographic data. The predicted and measured concentrations were compared by a visual predictive check (VPC). Maximum a <i>posteriori</i> Bayesian estimators were estimated to calculate the predicted AUC (AUC<sub>PRED</sub>). The accuracy and precision of the AUC<sub>PRED</sub> values were assessed by calculating the mean prediction error (MPE) and root mean squared prediction error (RMSE), and compared with the target AUC of 5924 μM∙min. VPC showed that most data fell within the 95% prediction interval. MPE and RMSE of AUC<sub>PRED</sub> were -5.8% and 20.6%, respectively, in the conventional dosing group and –2.1% and 14.0%, respectively, in the new dosing scheme group. These findings demonstrated the validity of a new dosing scheme for daily intravenous busulfan used as conditioning therapy for HCT.