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- 저자 : Sang-Chul Lim (검색결과 3,019 건)
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Lim, Sung-Chul,Duong, Hong-Quan,Parajuli, Keshab Raj,Han, Song Iy National Hellenic Research Foundation 2012 Oncology reports Vol.28 No.4
<P>Ursodeoxycholic acid (UDCA) has been regarded as a suppressor of gastrointestinal cancer, but the mechanisms underlying its antitumor effects are not fully understood. Previously, we reported the antitumor effect of UDCA by demonstrating that UDCA induces apoptosis of gastric cancer cells. Bile acids are known to activate the ERK pathway and ERK is a representative oncogenic kinase in cancer cells. Here, we investigated the role of ERK in UDCA-induced gastric cancer cell apoptosis. We found that UDCA enhanced the phosphorylation of ERK1/2 and MEK1/2. The prevention of MEK by the pharmacologic inhibitors PD98059 and U0126, resulted in decreased UDCA-induced apoptosis as shown by the reduction of apoptotic body formation, caspase-8 activity, and caspase-3, -6 and PARP cleavage, indicating that ERK exerts pro-apoptotic activity upon exposure to UDCA. In addition, U0126 reduced UDCA-triggered TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2/DR5) expression. In gene silencing studies, we observed that RNA interference of ERK2 decreased apoptosis and reduced DR5 overexpression. Lipid raft disrupting agent, methyl-β-cyclodextrin, blunted the phosphorylation of ERK1/2, indicating that ERK activation is regulated in a lipid raft-dependent manner. On the other hand, tumor-promoting bile acid, deoxycholic acid (DCA), also phosphorylated ERK in SNU601 cells. However, the DCA-triggered ERK pathway exerted anti-apoptotic function in the cells. Suppression of the ERK pathway enhanced DCA-induced apoptosis, and ERK activation was observed to be lipid raft-independently controlled. These results indicated that UDCA and DCA may cause differential responses in gastric cancer cells through the ERK signaling molecule. Thus, ERK activation may be a possible mechanism by which UDCA and DCA represent differential activities in gastrointestinal cancer.</P>
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Effects of Organic Additives on Grain Growth in Electrodeposited Cu Thin Film during Self-Annealing
Sung, Minjae,Kim, Hoe Chul,Lim, Taeho,Kim, Jae Jeong The Electrochemical Society 2017 Journal of the Electrochemical Society Vol.164 No.13
<P>The microstructural changes in electrodeposited Cu films during self-annealing is demonstrated in this study. The structural change is strongly influenced by the organic additives in the Cu electrodeposition. The use of either polyethylene glycol (PEG) or bis-(3-sulfopropyl)disulfide (SPS) decreases the Cu(111) grain size of deposited films, as the adsorption of the additives suppresses the surface diffusion of the Cu ions during the electrodeposition. After the electrodeposition, the average grain size of the deposited film was simultaneously increased by 10% in a self-annealing process to reduce the defect energy, which is mainly composed of the surface energy of the grains. Meanwhile, the grain grew 4 times larger than the as-deposited grain size during the self-annealing when both the PEG and SPS were introduced. The drastic grain growth was attributed to the accumulation of a high defect energy in the deposited film. The dynamic interaction between the co-adsorbed PEG and SPS on the Cu surface during the electrodeposition promotes an unoriented dispersion-type deposition, resulting in high-strain energy as well as surface energy. Releasing the strain energy accumulated by the high density of misorientation also leads to the simultaneous growth of Cu(200) grains. (c) 2017 The Electrochemical Society. All rights reserved.</P>
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National Program for Developing Biotech Crops in Korea
( Sung-han Park ),( Jung-il Cho ),( Youn-shic Kim ),( Su-min Kim ),( Su-mi Lim ),( Gang-seob Lee ),( Soo-chul Park ) 한국육종학회 2018 Plant Breeding and Biotechnology Vol.6 No.3
Global area of genetically modified crops (GM crops or biotech crops) continued to grow and reached 189.8 million hectares in 2017. Recently, a total of 24 countries approved GM crops for planting and an additional 43 countries formally imported biotech crops for food, feed, and processing, meaning that biotech crops are now commonly accepted in those countries. Although biotech crops should be one of key solutions for the challenge of the global food security which will be caused by population growth and climate change, it is real that there are still some debates to accept biotech crops in many countries including Korea. Because of that, safety assessment is an inevitable step for developing and commercializing GM crops. It is, therefore, very important to understand safety regulation. In addition to considering safety assessment, there are several critical points which we must consider before starting to produce GM crops such as target traits and their market values. In other words, passing safety regulation processing and proving market value should be considered first in the development of GM seeds. National Program for GM Crops (NCGC), one of the Next-Generation BioGreen 21 Programs organized by RDA in South Korea, was established in 2011 to develop biotech crops that will be used in the future to solve problems in our agriculture. To accomplish this mission, the NCGC carried out the exploration of useful functional genes, development of qualified events, and the safety assessment of developed events. This report will present the results of our research to develop useful biotech crops.
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Lim, Sung-Chul,Chae, Munseok S.,Heo, Jongwook W.,Hong, Seung-Tae Elsevier 2017 Journal of solid state chemistry Vol.254 No.-
<P><B>Abstract</B></P> <P>The electrochemical lithium-ion intercalation properties of molybdenum metal-cluster oxide Li<SUB> <I>x</I> </SUB>Mo<SUB>4</SUB>O<SUB>6</SUB> (0.33 ≤ <I>x</I> ≤ 1.0) in an organic electrolyte of 1.0M LiPF<SUB>6</SUB> in ethylene carbonate/dimethyl carbonate (1:2v/v) were characterized for the first time. Li<SUB>0.66</SUB>Mo<SUB>4</SUB>O<SUB>6</SUB> (tetragonal, <I>P4/mbm</I>, <I>a</I> = 9.5914(3) Å, <I>c</I> = 2.8798(1) Å, <I>V</I> = 264.927(15) Å<SUP>3</SUP>, <I>Z</I> = 2) was prepared via ion-exchange of indium and lithium ions from InMo<SUB>4</SUB>O<SUB>6</SUB> (tetragonal, <I>P4/mbm</I>, <I>a</I> = 9.66610(4) Å, <I>c</I> = 2.86507(2) Å, <I>V</I> = 267.694(2) Å<SUP>3</SUP>, <I>Z</I> = 2), which was first synthesized from a stoichiometric mixture of In, Mo, and MoO<SUB>3</SUB> via a solid-state reaction for 11h at 1100°C. Then, Li<SUB>0.33</SUB>Mo<SUB>4</SUB>O<SUB>6</SUB> was obtained via electrochemical charge of the electrode at 3.4V vs. Li. The electrochemical lithium-ion insertion into Li<SUB>0.33</SUB>Mo<SUB>4</SUB>O<SUB>6</SUB> occurs stepwise: three separate peaks were observed in the cyclic voltammogram and three quasi-plateaus in the galvanostatic profile, indicating a complicated intercalation mechanism. However, examination of the structural evolution of Li<SUB> <I>x</I> </SUB>Mo<SUB>4</SUB>O<SUB>6</SUB> during the electrochemical cycle indicated a reversible reaction over the measured voltage range (2.0–3.2V) and <I>x</I> range (0.33 ≤ <I>x</I> ≤ 1.00). Despite the excellent electrochemical reversibility, Li<SUB> <I>x</I> </SUB>Mo<SUB>4</SUB>O<SUB>6</SUB> showed poor rate performance with a low capacity of 36.3mAhg<SUP>−1</SUP> at a rate of 0.05C. Nonetheless, this work demonstrates a new structural class of lithium cathode materials with condensed metal clusters and 1D tunnels, and provides a host material candidate for multivalent-ion batteries.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An electrochemical Li-ion intercalation into Mo metal-cluster oxide is demonstrated. </LI> <LI> Reversible structural changes are observed during the electrochemical cycle. </LI> <LI> A new structural class of lithium cathode materials is provided. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>The electrochemical lithium-ion intercalation properties of a molybdenum metal-cluster oxide of Li<SUB> <I>x</I> </SUB>Mo<SUB>4</SUB>O<SUB>6</SUB> (0.33 ≤ <I>x</I> ≤ 1.0) in an organic electrolyte of 1.0M LiPF<SUB>6</SUB> in EC/DMC (1:2v/v) were characterized for the first time.</P> <P>[DISPLAY OMISSION]</P>
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Lim, Dong-Hyun,Ki, Kwang-Seok,Park, Seong-Min,Kim, Sang-Bum,Park, Ji-Hoo,Jung, Jeong Sung,Vijayakumar, Mayakrishnan,Kim, Dong-Hyeon,Lee, Hyun-Jeong,Choi, Hee-Chul,Kim, Tae-Il The Korean Society of Grassland and Forage Science 2019 한국초지조사료학회지 Vol.39 No.4
The present study was designed to determine the effect of barn or cycle of grazing on changes of biochemical metabolites in prepartum and changes of milk composition in postpartum of dairy cows. For this purpose, a total of sixteen 25 months old Holstein primiparous dairy cows were allocated in two groups (n=8) with an average body weight of 571.61 ± 35.30 kg (Barn) and 578.10 ± 39.20 kg (Grazing). The study was conducted from June 2018 to October 2018. Results revealed that barn raised dairy cows had a higher increase in their serum albumin and calcium level on day 14 prepartum. However, the level of palmitic acid, saturated fatty acid increased significantly, and the level of fat, oleic acid, γ-linoleic acid, arachidonic acid and unsaturated fatty acids decreased significantly in barn raised dairy cow's milk on day 14 postpartum. There were no significant differences observed with respect to all other biochemical metabolites, fatty acids and minerals between barn raised and cycle grazing dairy cows during prepartum and postpartum. Our study results could serve to a better understanding of barn raised cow with respect to changes of biochemical metabolites in prepartum and changes of milk composition, fatty acids and minerals content in grazing dairy cows in postpartum for estimating their physiological status.
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Sung-Hun Lim,Jin-Seok Kim,Jong-Fil Moon,Jae-Chul Kim,Sang-Bong Rhee,Chul-Hwan Kim,Ok-Bae Hyun IEEE 2009 IEEE transactions on applied superconductivity Vol.19 No.3
<P>We suggested that the neutral line is a more effective location for a superconducting fault current limiter (SFCL) in a three-phase power system. To confirm it, we analyzed the quench and recovery characteristics of SFCL applied into the neutral line in cases of non-symmetrical ground faults, such as single line-to-ground and double line-to-ground faults. Through a comparative analysis based on the experimental results for two SFCLs applied either to the neutral line or to the three-phase power line, it was confirmed that the SFCL applied into the neutral line of the power system was more advantageous from the viewpoint of both the practical use of the SFCL and the SFCL's coordination with other related protective devices in the power system.</P>
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Changes in metabolic syndrome in American and Korean youth, 1997-2008.
Lim, Soo,Jang, Hak Chul,Park, Kyong Soo,Cho, Sung Il,Lee, Man-Gyoon,Joung, Hyojee,Mozumdar, Arupendra,Liguori, Gary American Academy of Pediatrics [etc.] 2013 Pediatrics Vol.131 No.1
<P>Metabolic syndrome (MetSyn) in children and adolescence is increasing worldwide; however, its pattern may be different between Asians and Americans. We compare the prevalence and patterns of MetSyn between American and Korean children and adolescents between roughly 1998 and 2007.</P>
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Current Limiting and Recovery Characteristics of SFCLs Using Magnetic Coupling of Two Coils
Sung-Hun Lim,Jong-Fil Moon,Jae-Chul Kim IEEE 2009 IEEE transactions on applied superconductivity Vol.19 No.3
<P>Superconducting fault current limiters (SFCLs) using magnetic coupling of two coils can be divided into the insulated type SFCL and the non-insulated type SFCL depending on whether the two coils are insulated through one iron core or not. Among such SFCLs, the transformer type SFCL belongs to the insulated type SFCL because of its insulated two coils. On the other hand, the flux-lock type SFCL, its two coils electrically connected in parallel or series, can be classified into the non-insulated type SFCL. Basically, the structural component and the operational principle of these SFCLs rely upon the magnetic coupling of two coils, and might therefore be considered to be the same. However, there are important differences in the current limiting and the recovery characteristics of these SFCLs depending on design conditions such as the winding direction and the inductance ratio between two coils.</P>
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