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- 저자 : Saini, Sharanjot (검색결과 132 건)
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Parampreet Singh Saini,Rajesh Kumar,Manu Saini,Tarush Gupta,Sunil Gaba,Ramesh Kumar Sharma 대한두개안면성형외과학회 2024 Archives of Craniofacial Surgery Vol.25 No.4
Background: The eyes are the central aesthetic unit of the face. Maxillofacial trauma can alter facial proportions and affect visual function with varying degrees of severity. Conventional approaches to reconstruction have numerous limitations, making the process challenging. The primary objective of this study was to evaluate the application of three-dimensional (3D) navigation in complex unilateral orbital reconstruction. Methods: A prospective cohort study was conducted over 19 months (January 2020 to July 2021), with consecutive enrollment of 12 patients who met the inclusion criteria. Each patient was followed for a minimum period of 6 months. The principal investigator carried out a comparative analysis of several factors, including fracture morphology, orbital volume, globe projection, diplopia, facial morphic changes, lid retraction, and infraorbital nerve hypoesthesia. Results: Nine patients had impure orbital fractures, while the remainder had pure fractures. The median orbital volume on the normal side (30.12 cm3; interquartile range [IQR], 28.45–30.64) was comparable to that of the reconstructed orbit (29.67 cm3; IQR, 27.92–31.52). Diplopia improved significantly (T(10) = 2.667, p= 0.02), although there was no statistically significant improvement in globe projection. Gross symmetry of facial landmarks was achieved, with comparable facial width-to-height ratio and palpebral fissure lengths. Two patients reported infraorbital hypoesthesia at presentation, which persisted at the 6-month follow-up. Additionally, five patients developed lower lid retraction (1–2 mm), and one experienced implant impingement at the infraorbital border. Conclusion: Our study provides level II evidence supporting the use of 3D navigation to improve surgical outcomes in complex orbital reconstruction.
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Saini, Ramesh Kumar,Moon, So Hyun,Gansukh, Enkhtaivan,Keum, Young-Soo Elsevier 2018 Food chemistry Vol.266 No.-
<P><B>Abstract</B></P> <P>The foremost problem in carotenoid research is the excessive cost and difficulty of maintaining pure carotenoid compounds. This work presents an economical, efficient, and simplified one-step scheme for the purification of four major xanthophyll carotenoids from lettuce by utilizing preparative thin layer chromatography on Hyflo-Super-Cel: MgO (Heavy): calcium sulfate hemihydrate (9:9:2 w/w) based adsorbent. The mobile phase of acetone: hexane (1:1) provided the perfect separation of major xanthophylls, resulting in 95–96% purity after just single-step separation, with no interference from chlorophylls or other minor carotenoids. The identity of carotenoids was confirmed by absorption spectroscopy, chemical tests and APCI<SUP>+</SUP>–MS/MS. The proposed scheme can be used to isolate the carotenoids at the analytical and preparative scale. In anticancer studies, among four xanthophylls, 9-<I>Z</I>-neoxanthin was found most potent for reduction of cell viability of cervical (HeLa) and lung cancer (A549) cells, with IC<SUB>50</SUB> values of 3.8 and 7.5 μM, respectively.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hyflo-Super-Cel: MgO: calcium sulfate hemihydrate based adsorbent was used. </LI> <LI> The mobile phase of acetone: hexane (1:1) provided the perfect separation. </LI> <LI> Utilizing proposed scheme carotenoids can be isolated with 95–96% purity. </LI> <LI> 9-<I>Z</I>-neoxanthin is the most potent inhibitor of HeLa and A549 cells proliferation. </LI> </UL> </P>
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Saini, Ramesh Kumar,Keum, Young-Soo American Chemical Society 2018 Journal of agricultural and food chemistry Vol.66 No.21
<P>Carotenoids are a diverse group of tetraterpenoid pigments that play indispensable roles in plants and animals. The biosynthesis of carotenoids in plants is strictly regulated at the transcriptional and post-transcriptional levels in accordance with inherited genetic signals and developmental requirements and in response to external environmental stimulants. The alteration in the biosynthesis of carotenoids under the influence of external environmental stimulants, such as high light, drought, salinity, and chilling stresses, has been shown to significantly influence the nutritional value of crop plants. In addition to these stimulants, several pre- and postharvesting cultivation practices significantly influence carotenoid compositions and contents. Thus, this review discusses how various environmental stimulants and pre- and postharvesting factors can be positively modulated for the enhanced biosynthesis and accumulation of carotenoids in the edible parts of crop plants, such as the leaves, roots, tubers, flowers, fruit, and seeds. In addition, future research directions in this context are identified.</P> [FIG OMISSION]</BR>
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Saini, S.,Takamura, M.,Mukaida, M.,Kim, S.-J. Elsevier 2011 Current Applied Physics Vol.11 No.5
<P><B>Abstract</B></P><P>The thin film of <I>a</I>-axis oriented YBa<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>7</SUB> (Y123) were grown on SrLaGaO<SUB>4</SUB> (100) substrate with a buffer layer of 50 nm thick Gd<SUB>2</SUB>CuO<SUB>4</SUB> using pulsed laser deposition technique. The thickness of Y123 thin film is about 400 nm CuO<SUB>2</SUB> planes are aligned perpendicular to the substrate in the thin films. A micron-bridge was fabricated using focused ion beam milling technique in such a way that the current was forced to flow along the <I>c</I>-axis in thin film. Intrinsic Josephson junctions are aligned along the <I>c</I>-axis. The dimensions of bridge are 1 μm in length along the <I>c</I>-axis and 5 μm in width along the <I>b</I>-axis. Transition temperature (<I>T<SUB>cON</SUB></I>) is about 84 K with single phase. The critical current density (<I>J<SUB>c</SUB></I>) of 2 × 10<SUP>6</SUP> A/cm<SUP>2</SUP> was measured from current–voltage (<I>I–V</I>) characteristics at 10 K. The samples were irradiated with external microwave of 20 GHz at different power and the <I>J<SUB>c</SUB></I> was suppressed as we increased the power. This suppression in <I>J<SUB>c</SUB></I> indicates the formation of layered structure with strong coupling. The voltage steps are appeared in non-linear <I>I–V</I> characteristics with microwave irradiation. The voltage steps are collective response of intrinsic Josephson junctions of micron-bridge.</P>
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Saini, K.K.,Sharma, S.D.,Chanderkant,Kar, M.,Singh, D.,Sharma, C.P. North-Holland 2007 Journal of non-crystalline solids Vol.353 No.24
Nanocrystalline thin films of titanium dioxide have been fabricated on glass and silica substrates from partially hydrolyzed precursor solution. These films were subjected to heat treatment for 1h at temperatures 100, 200, 300, 400, 500, 600, 700, 800 and 900<SUP>o</SUP>C and characterized by XRD, SEM, XPS and optical techniques. As deposited films are found to be amorphous and also contain hydroxyl and organic functional groups. Films heat treated above 100<SUP>o</SUP>C do not contain hydroxyl and organic functional groups. Microcrystalline behavior is observed in the films heat treated above 300<SUP>o</SUP>C. Crystallite size increases from ∼5 to 50nm as sintering temperature is increased from 300 to 700<SUP>o</SUP>C. Formation of anatase phase with c-axis length 7.03A is observed in the films annealed up to 700<SUP>o</SUP>C. These films peel off from the substrate beyond 700<SUP>o</SUP>C annealing temperature. Density as well as refractive index of the films increases with increase in annealing temperature up to 700<SUP>o</SUP>C. Refractive index is found to show Cauchys behavior. Transmission better than 70% is observed in the visible range. There is a strong absorption around 370nm, which is attributed to band gap absorption of the material.
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Saini Mandeep,Kataruka Mohit,Gogoi Biraj,Sharma Vyom,Madan Gurdarshdeep Singh,Sood Chetan 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.2
Study Design: Retrospective pilot study. Purpose: To assess the incidence of renal tract abnormalities using ultrasonography (US) in a military cohort with traumatic spinal cord injury (TSCI) at a tertiary level spinal cord injury center. Overview of Literature: Neurogenic bladder in TSCI patients results in significant urological morbidity. There is lack of data for these patients during the first 18 months of long-term rehabilitation in an institutional setting. Methods: We retrospectively reviewed patient records to collect data on demographic characteristics, injury level, injury severity, time since injury, bladder management methods (such as an indwelling catheter [IC], clean intermittent catheterization [CIC], or self-voiding [S]); we correlated these data with the findings of the renal tract US. Results: The study included 73 out of 81 male participants. The mean patient age was 29.99 years; the study group included 34.2% tetraplegics and 65.8% people with paraplegia. The time since injury was 6–12 months for 42.5% of the subjects and 12–18 months for 57.5% of the subjects. A normal US scan was recorded in 65.7% patients, and bladder trabeculation was the commonest finding in 15.1% of the subjects, followed by hydronephrosis (HDN) in 12.3%, and renal calculus and atrophy in 1.3% participants each. We found 22.22% of the IC group participants had higher US abnormalities than those in the reflex voiding group (statistically non-significant difference, p=0.7). Trabeculations (21.4%) and HDN (19%) were more common in those who had sustained the injury 12–18 months previously as compared to that in those who had injured themselves 6–12 months previously (p=0.04). The proportion of patients who had a normal US scan was higher in the group who sustained the injury 6–12 months previously versus those who had sustained the injury 12–18 months previously; the difference was statistically significant (p=0.02). There was no significant (p=0.72) correlation in the bladder management method, injury level, and renal tract abnormalities between the groups. Conclusions: This retrospective study shows that 65% of TSCI participants had no renal tract abnormality on US scan and bladder trabeculation ruled out as the most common finding. Long-term supervised rehabilitation may help achieve good renal quality of life; however, further prospective trials are required on this subject.
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Saini, Nisha,Kumar, Rajeev,Lgaz, Hssane,Salghi, Rachid,Chung, Ill-Min,Kumar, Sumit,Lata, Suman Elsevier 2018 Journal of molecular liquids Vol.269 No.-
<P>Corrosion protective performance of commercial mild steel (soft steel) by urispas drug was evaluated by gravimetric measurements, potentiostatic polarization and electrochemical impedance spectroscopy in 1 M H2SO4 solution. The results indicate that urispas acts as quite a good corrosion constraint for mild steel exhibiting 97.85% inhibition efficiency at 150 ppm of the drug at 303 K on polarizing it electrochemically which is a quite minified amount of urispas. Weight loss study also shows that inhibition efficiency gets optimized at 150 ppm of the drug molecule at lower temperature. Polarization curves depict that the drug acts as a mixed type inhibitor. The results of electrochemical impedance spectroscopy (EIS) indicate that the charge transfer phenomenon controlled the corrosion reaction. The morphological behavior of the uncorroded and corroded coupons was investigated by scanning electron microscopy and atomic force microscopy studies. The mechanism of adsorption from the variation of inhibition effectiveness with kinetic and activation parameter through Langmuir, Freundlich, Frumkin and Flory-Huggins isotherm, put forward a significant physiochemical mode of interaction of the drug on the metal surface. The outcomes obtained from all the experimental techniques and the information obtained via molecular dynamics (MD) and density functional theory (DFT) evaluation are in good correlation. (C) 2018 Elsevier B.V. All rights reserved.</P>
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Saini, Ramesh Kumar,Keum, Young-Soo Elsevier 2018 Life sciences Vol.203 No.-
<P><B>Abstract</B></P> <P>Linoleic acid (LA) (n−6) and α-linolenic acid (ALA) (n−3) are essential fatty acids (EFAs) as they cannot be synthesized by humans or other higher animals. In the human body, these fatty acids (FAs) give rise to arachidonic acid (ARA, n−6), eicosapentaenoic acid (EPA, n−3), and docosahexaenoic acid (DHA, n−3) that play key roles in regulating body homeostasis. Locally acting bioactive signaling lipids called eicosanoids derived from these FAs also regulate diverse homeostatic processes. In general, ARA gives rise to pro-inflammatory eicosanoids whereas EPA and DHA give rise to anti-inflammatory eicosanoids. Thus, a proportionally higher consumption of n−3 PUFAs can protect us against inflammatory diseases, cancer, cardiovascular diseases, and other chronic diseases. The present review summarizes major sources, intake, and global consumption of n−3 and n−6 PUFAs. Their metabolism to biosynthesize long-chain PUFAs and eicosanoids and their roles in brain metabolism, cardiovascular disease, obesity, cancer, and bone health are also discussed.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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