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박새봄(Park, Sae Bom),김진화(Kim, Jin Hwa) 한국평생교육학회 2009 평생교육학연구 Vol.15 No.3
평생교육학에서 네트워크는 평생학습사회라는 공통가치를 실현하는 실천영역의 중요한 분야이다. 평생교육 실천현장에서 네트워크의 성공은 평생교육사의 네트워킹 수행역량과 밀접한 관련이 있다. 따라서 본 연구의 목적은 평생교육 실천현장에 종사하는 평생교육사의 네트워킹 행위를 직업적 전문성과 관련된 고유한 역할과 직무로 규정하고 평생교육사의 네트워킹 행위를 계량적으로 유형화시켜 그 타당성을 확인하고 수행역량과의 관계를 분석하는 것이었다. 본 연구의 결과, 평생교육사의 네트워킹 행위가 목적의 일치성 준거에 따라 전략형 네트워킹 행위와 교환형 네트워킹 행위, 관계의 친숙성 준거에 따라 개방형 네트워킹 행위와 선택형 네트워킹 행위로 범주화 되었다. 또한 행위의 주도성 준거에 따라 주도형 네트워킹 행위와 수동형 네트워킹 행위, 파워(권한)관계의 영향성 준거에 따라 의존형 네트워킹 행위와 소신형 네트워킹 행위로 유형화할 수 있음이 계량적으로 확인되었다. 그리고 평생교육사의 네트워킹 수행역량은 평생교육사의 평생교육적 특성에 따라 유의미한 차이가 있는 것으로 밝혀졌으며, 또한 평생교육사의 네트워킹 행위 유형 중 주도형 네트워킹 행위, 전략형 네트워킹 행위, 소신형 네트워킹 행위 유형이 네트워크 과업 수행역량에 영향을 미치는 것을 확인되었다. In the academic field of lifelong education, a network is an important part of practice that realizes as common value toward the lifelong learning society. The success of network in lifelong education practice field depends on the lifelong educator's networking performance competency. So far, the related studies have largely focused on network of lifelong education institutions. Thus, relatively far fewer studies have been conducted on the lifelong educator's networking behaviors. The objectives of this study were to classify and validity verification of the lifelong educator's networking behaviors, to analyze of the relationship between the lifelong educator's characteristics variables and patterns of networking behaviors, to explore of the relationship between the lifelong educator's patterns of networking behaviors and competency to perform network tasks, and to analyze the effects of the lifelong educator's patterns of networking behaviors on his competency to perform network tasks. The findings of this research were as follows. First, eight patterns of networking behaviors were identified through the factor analysis. Second, the lifelong educator's networking behaviors can be classified into the following eight patterns: strategy patterns, exchange patterns, open patterns, selective patterns, leading patterns, passivity patterns, active patterns, and dependency patterns. Third, the relationship between eight patterns of networking behaviors and the lifelong educator's background variables was found to be statistically significant. Fourth, leading style of networking behavior, strategy style of networking behavior, and rationality style of networking behavior were found to have effects on the lifelong educator's competency to perform the network task though multiple regression analysis.
Kang, Yun Pyo,Lee, Won Jun,Hong, Ji Yeon,Lee, Sae Bom,Park, Jeong Hill,Kim, Donghak,Park, Sunghyouk,Park, Choon-Sik,Park, Sung-Woo,Kwon, Sung Won American Chemical Society 2014 JOURNAL OF PROTEOME RESEARCH Vol.13 No.9
<P>To better understand the respiratory lipid phenotypes of asthma, we developed a novel method for lipid profiling of bronchoalveolar lavage fluid (BALF) using HPLC-QTOF-MS with an internal spectral library and high-throughput lipid-identifying software. The method was applied to BALF from 38 asthmatic patients (18 patients with nonsteroid treated bronchial asthma [NSBA] and 20 patients with steroid treated bronchial asthma [SBA]) and 13 healthy subjects (NC). We identified 69 lipids, which were categorized into one of six lipid classes: lysophosphatidylcholine (LPC), phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylserine (PS), sphingomyelin (SM) and triglyceride (TG). Compared with the NC group, the individual quantity levels of the six classes of lipids were significantly higher in the NSBA subjects. In the SBA subjects, the PC, PG, PS, SM, and TG levels were similar to the levels observed in the NC group. Using differentially expressed lipid species (<I>p</I> value < 0.05, FDR < 0.1 and VIP score of PLS-DA > 1), 34 lipid biomarker candidates with high prediction performance between asthmatics and controls were identified (AUROC > 0.9). These novel findings revealed specific characteristics of lipid phenotypes in asthmatic patients and suggested the importance of future research on the relationship between lipid levels and asthma.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2014/jprobs.2014.13.issue-9/pr5002059/production/images/medium/pr-2014-002059_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr5002059'>ACS Electronic Supporting Info</A></P>
Cytokine expression and localization during the development of glomerulosclerosis in FGS mice
Park, Sang-Joon,Lee, Sae-Bom,Lee, Young-Ho,Ryu, Si-Yun,Jeong, Kyu-Shik,Lee, Cha-Soo Korean Society of Veterinary Pathology 1999 한국수의병리학회지 Vol.3 No.1
To elucidate the mechanism of age-related development in FGS/NgaKIST mice with spontaneous glomerulosclerotic lesion, we examined expression and localization of various cytokine mRNA in the kidney in the progression of diseases. This mouse model is the first to develop spontanously occuring glomerosclerotic lesion in the kidney. In this study, we detected the up-regulation of local cytokine genes such as IL-1$\beta$, IL-2, IL-6, IL-10, TNF-$\alpha$, TGF-$\beta$, and IFN- $\gamma$ in the kidneys. In RT-PCR and Southern blot analysis, we detected gradual expressions of cytokine mRNA of IL-1$\beta$, IL-2, IL-6, IFN- $\gamma$, and TNF $\alpha$ mRNA during the course of disease. Other cytokines including IL -10 and TGF -$\beta$ were found to be appeared the slightly expressed level at 3 to 12 weeks before onset of inflammatory lesion but they are highly expressed at the end-stage of the disease accompaning high proteinurea and wasting. In situ RT-PCR, each cytokine mRNA were specifically localized in a variety of cells including mesangial, endothelial, parietal epithelial, tubular epithelial, arterial muscle cell, and infiltrated inflammatory cells. In addition, TNF - $\alpha$was detected moderately in the visceral and parietal epithelial cell, but weakly in endothelial and mesangial cells, whereas IL-1 $\beta$ and IL -6 were strong in mesangial regions. IL-6 and TNF- $\alpha$ was highly localized in the damaged proximal and collecting tubules. Especially, TGF -$\beta$ mRNA was highly found in mesangial cells within glomerulus and interstitium during the end-stage of this disease.. These results indicate that pro inflammatory cytokines such as IL-1 $\beta$, IL-2, IL-6, and TNF- $\alpha$ were gradually expressed from the early stage of this disease to the end-stage, and that IL-10 and TGF-$\beta$ may be important in the accumulation of extracellular matrix(ECM) within glomerulus and periglomerular fibrosis in the progression of this disease as well as tissue destruction in end-stage of this disease.
Park, Ki Seong,Song, Ho-Chun,Cho, Sang-Geon,Kang, Sae-Ryung,Kim, Jahae,Jun, Haeng Man,Song, Minchul,Jeong, Geum-Cheol,Park, Hee Jeong,Kwon, Seong Young,Min, Jung-Joon,Bom, Henry Hee-Seung The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.3
Purpose Closed-mouth bone scintigraphy (CM scan) and closed-mouth single-photon emission computed tomography (CM SPECT) are used for conventional evaluation of osteoarthritis of the temporomandibular joint (TMJ). However, the adequacy of open-mouth bone scintigraphy (OM scan) has not yet been evaluated. Therefore, the purpose of this study was to compare the diagnostic performance of CM scan, CM SPECT, and OM scan. Methods Thirty-six patients with suspicion of an abnormality of the TMJ and who underwent a $^{99m}Tc-HDP$ CM scan, CM SPECT, and an OM scan were enrolled. The scans were assessed visually for the presence of positive focal uptake in the TMJ. Osteoarthritis was defined as arthralgia plus crepitus or radiologic signs of arthrosis. Results Of 72 TMJs, 21 (29.2 %) were diagnosed with osteoarthritis. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 90.5 %, 49.0 %, 42.2 %, 92.6 % and 61.1 % for the CM scan, 81.0 %, 58.8 %, 44.7 %, 88.2 % and 65.3 % for CM SPECT, and 81.0 %, 82.4 %, 65.4 %, 91.3 % and 81.9 % for the OM scan, respectively. The accuracy of the OM scan was higher than that of CM SPECT and the CM scans (p = 0.004 and p < 0.001, respectively). Conclusions The OM scan was more accurate than the conventional CM scan and even CM SPECT for diagnosing TMJ osteoarthritis.
H9 Induces Apoptosis via the Intrinsic Pathway in Non-Small-Cell Lung Cancer A549 Cells
( Sae Bom Kwon ),( Min Je Kim ),( Sun Young Ham ),( Ga Wan Park ),( Kang Duk Choi ),( Seung Hyun Jung ),( Do Young Yoon ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.3
H9 is an ethanol extract prepared from nine traditional/medicinal herbs. This study was focused on the anticancer effect of H9 in non-small-cell lung cancer cells. The effects of H9 on cell viability, apoptosis, mitochondrial membrane potential (MMP; Δψm), and apoptosisrelated protein expression were investigated in A549 human lung cancer cells. In this study, H9-induced apoptosis was confirmed by propidium iodide staining, expression levels of mRNA were determined by reverse transcriptase polymerase chain reaction, protein expression levels were checked by western blot analysis, and MMP (Δψm) was measured by JC- 1 staining. Our results indicated that H9 decreased the viability of A549 cells and induced cell morphological changes in a dose-dependent manner. H9 also altered expression levels of molecules involved in the intrinsic signaling pathway. H9 inhibited Bcl-xL expression, whereas Bax expression was enhanced and cytochrome C was released. Furthermore, H9 treatment led to the activation of caspase-3/caspase-9 and proteolytic cleavage of poly(ADPribose) polymerase; the MMP was collapsed by H9. However, the expression levels of extrinsic pathway molecules such as Fas/FasL, TRAIL/TRAIL-R, DR5, and Fas-associated death receptor were downregulated by H9. These results indicated that H9 inhibited proliferation and induced apoptosis by activating intrinsic pathways but not extrinsic pathways in human lung cancer cells. Our results suggest that H9 can be used as an alternative remedy for human non-small-cell lung cancer.
( Sae-bom Yoon ),( Hae-ryong Park ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.4
Microenvironmental stress, which is naturally observed in solid tumors, has been implicated in anticancer drug resistance. This tumor-specific stress causes the degradation of topoisomerase IIα, rendering cells resistant to topoisomerase IIα-targeted anticancer agents. In addition, microenvironmental stress can induce the overexpression of 78kDa glucose regulated protein (GRP78), which can subsequently block the activation of apoptosis induced by treatment with anticancer agents. Therefore, inhibition of topoisomerase IIα degradation and reduction in GRP78 expression may be effective strategies for inhibiting anticancer drug resistance. In this study, we investigated the active compound arctigenin, which inhibited microenvironmental stress-induced etoposide resistance in HT-29 cells. Arctigenin was also highly toxic to etoposide-resistant HT-29 cells, with an IC<sub>50</sub> value of 10 μM for colony formation. We further showed that arctigenin inhibited the degradation of topoisomerase IIα and reduced the expression of GRP78. Thus, these results suggest that arctigenin is a novel therapeutic agent that inhibits resistance to etoposide associated with microenvironmental stress conditions.