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Choi, S. W.,Bae, W. J.,Ha, U. S.,Hong, S. H.,Lee, J. Y.,Kim, S. W.,Cho, H. J. Springer Science + Business Media 2017 World journal of urology Vol.35 No.3
<P>To investigate the factors predictive of surgical outcomes of tubeless percutaneous nephrolithotomy (TPCNL) and to compare the predictability and accuracy of the Guy's stone score, S.T.O.N.E. nephrolithometry, and CROES nomogram. We reviewed retrospectively the surgical outcomes recorded consecutively and imaging data of preoperative computed tomography scans of 141 patients who had undergone TPCNL from June 2012 to October 2015. Guy's, S.T.O.N.E., and CROES stone-scoring systems (SSSs) and other prognostic factors were assessed using univariate and multivariate statistical analyses. The initial stone-free and complication rates after TPCNL were 78.7 (111/141) and 17.0 % (24/141). On univariate analysis, all three scoring systems were identified as significant factors in terms of stone-free rate (SFR). The multivariate logistic regression analysis showed that the Guy's stone score and stone burden 385 mm(2) had significant correlations with stone-free status [odds ratios (OR) = 3.220, p = 0.001 and OR = 6.451, p = 0.002, respectively]. Guy's stone score (OR = 1.879, p = 0.013) was an independent risk factor for the development of complications. The area under the receiver operating characteristic (ROC) curves for the Guy's, S.T.O.N.E., and CROES SSSs and stone burden showed good results (0.821, 0.816, 0.820, and 0.800, respectively). Pairwise comparison of ROC curves showed that there was no significant difference between each final score and stone burden. Of the three scoring systems, Guy's stone score was the only significant predictive factor for SFR and complication rates after TPCNL in the multivariate logistic regression analysis. Stone burden was significantly associated with a postoperative stone-free status (SFS).</P>
S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis
Yi, S.,Um, S.,Lee, J.,Yoo, J.,Bang, S.,Park, E.,Lee, M.,Nam, K.,Jeon, Y.,Park, J.,You, J.,Lee, S.J.,Bae, G.U.,Rhie, J.,Kozma, Sara C.,Thomas, G.,Han, J.W. Cell Press 2016 Molecular Cell Vol.62 No.3
S6K1 has been implicated in a number of key metabolic responses, which contribute to obesity. Critical among these is the control of a transcriptional program required for the commitment of mesenchymal stem cells to the adipocytic lineage. However, in contrast to its role in the cytosol, the functions and targets of nuclear S6K1 are unknown. Here, we show that adipogenic stimuli trigger nuclear translocation of S6K1, leading to H2BS36 phosphorylation and recruitment of EZH2 to H3, which mediates H3K27 trimethylation. This blocks Wnt gene expression, inducing the upregulation of PPARγ and Cebpa and driving increased adipogenesis. Consistent with this finding, white adipose tissue from S6K1-deficient mice exhibits no detectable H2BS36 phosphorylation or H3K27 trimethylation, whereas both responses are highly elevated in obese humans or in mice fed a high-fat diet. These findings define an S6K1-dependent mechanism in early adipogenesis, contributing to the promotion of obesity.
Future Direction of Health Informatics in Sri Lanka
Jeong yee Bae,S.P.R. Chandralatha,W.S.M.S.S. Weerasekara,K.H.R. Sandyani De Silva,T.A. Asurakkody,S.M.S.R. Senadipathi,K.A.D.S. Kodithuwakku,G.D.R. Deepika 위기관리 이론과 실천 2016 Journal of Safety and Crisis Management Vol.6 No.2
Purpose: To propose suggestions for future direction of health informatics in Sri Lanka with the understanding of existing situation in Sri Lanka and world. Methodology: Online literature search from journal articles and other documents Findings: Application of Health Information System (HIS) in health informatics has been implemented on project basis at district level by facing various barriers. Experience of efficiency and effectiveness have been motivated to expand the application up to national level. Conclusion: Applications of health informatics in Sri Lanka is limited when comparing with other countries in the world due to various barriers.
Sound wave stimulates plant gene response and improve salt stress tolerance of rice seedlings
M. J. Jeong,D. W. Bae,H. H. Bae,S. C. Shin,S. I. Lee,J. A Kim,S. H. Park,D. H. Kim,S. C. Park 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
We investigated whether sound could alter gene expression in plants. Using a sound-treated subtractive library, a set of sound-responsive genes in plants was demonstrated through mRNA expression analyses. Of them, the rbcS and ald genes, which are light responsive, up-regulated their expression with sound treatment in both light and in dark conditions. This suggested that sound could be used as a gene regulator instead of light. When we analyzed ald gene expression using various single wavelengths, a significant increase in mRNA levels was found at 125 or 250 Hz but decreased at 50 Hz, indicating that the gene responded to sound in a wavelength-specific manner. To determine whether the ald promoter respond to sound, we generated transgenic rice plants harboring the chimeric gene consisting of a 1,506-bp promoter fragment of the ald gene fused to Escherichia coli GUS reporter gene. Analyses of mRNA expressison level of three independent transgenic lines sound-treated with 50 or 250 Hz for 4 h showed that the Gus gene expression in all three transgenic lines was up regulated by 250 Hz, but down regulated by 50 Hz. These results correlated with sound responsive mRNA expression pattern observed for the ald gene in rice plants, indicating that the 1,506-bp ald promoter confers sound-responsiveness on a reporter gene in transgenic rice plants. We also investigated whether sound waves could improve salt tolerance in rice seedling. The rice seedlings were sound treated with 800 Hz for 1hr, and then treated with 0, 75, 150, and 225mM NaCl for 3 days to observe changes in physiological and morphological aspects. Sound treatment seedlings resulted in enhanced salt stress tolerance, mainly demonstrated by the sound treated seedlings exhibiting of increased root relative water contents (RWC), root length and weight, photochemical efficiency (ratio of variable to maximum fluorescence, Fv/Fm), and germination rate under salt stress condition. This demonstrates that a specific sound wave might be used, not only to alter gene expression in plant, but also to improve salt stress tolerance.
Bae, J.S.,Park, S.H.,Jamiyandorj, U.,Kim, K.M.,Noh, S.J.,Kim, J.R.,Park, H.J.,Kwon, K.S.,Jung, S.H.,Park, H.S.,Park, B.H.,Lee, H.,Moon, W.S.,Sylvester, K.G.,Jang, K.Y. American Association of Pathologists and Bacteriol 2016 The American journal of pathology Vol.186 No.12
<P>Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists, and protein kinase CK2 alpha 1 (CSNK2A1) has been shown to be involved in tumorigenesis by phosphorylating various proteins, including SIRT1. Therefore, we evaluated the roles of CSNK2A1, SIRT6, and phosphorylated SIRT6 and their relationships in breast carcinoma. Nuclear expression of CSNK2A1 and SIRT6 predicted shorter overall survival and relapse-free survival by multivariate analysis. Inhibition of CSNK2A1 decreased the proliferative and invasive activity of cancer cells. In addition, CSNK2A1 was bound to SIRT6 and phosphorylated SIRT6; evidence for this is provided from immunofluorescence staining, co-immunoprecipitation of CSNK2A1 and SIRT6, a glutathione S-transferase pull-down assay, an in vitro kinase assay, and transfection of mutant CSNK2A1. Knockdown of SIRT6 decreased the proliferation and invasiveness of cancer cells. Overexpression of SIRT6 increased proliferation, but mutation at the Ser338 phosphorylation site of SIRT6 inhibited the proliferation of MCF7 cells. Moreover, both knockdown of SIRT6 and a mutation at the phosphorylation site of SIRT6 decreased expression of matrix metallopeptidase 9, beta-catenin, cyclin D1, and NF-kappa B. Especially, SIRT6 expression was associated with the nuclear localization of B-catenin. This study demonstrates that CSNK2A1 and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.</P>