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Nodeless superconductivity in the infinite-layer electron-doped cuprate superconductorSr0.9La0.1CuO2
Khasanov, R.,Shengelaya, A.,Maisuradze, A.,Di Castro, D.,Savić,, I. M.,Weyeneth, S.,Park, M. S.,Jang, D. J.,Lee, S.-I.,Keller, H. American Physical Society 2008 Physical review. B, Condensed matter and materials Vol.77 No.18
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
Keller, Tracy L,Zocco, Davide,Sundrud, Mark S,Hendrick, Margaret,Edenius, Maja,Yum, Jinah,Kim, Yeon-Jin,Lee, Hak-Kyo,Cortese, Joseph F,Wirth, Dyann F,Dignam, John David,Rao, Anjana,Yeo, Chang-Yeol,Maz Nature Publishing Group, a division of Macmillan P 2012 Nature chemical biology Vol.8 No.3
Febrifugine, the bioactive constituent of one of the 50 fundamental herbs of traditional Chinese medicine, has been characterized for its therapeutic activity, though its molecular target has remained unknown. Febrifugine derivatives have been used to treat malaria, cancer, fibrosis and inflammatory disease. We recently demonstrated that halofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T<SUB>H</SUB>17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Here we show that HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity; this inhibition is reversed by the addition of exogenous proline or EPRS. We further show that inhibition of EPRS underlies the broad bioactivities of this family of natural product derivatives. This work both explains the molecular mechanism of a promising family of therapeutics and highlights the AAR pathway as an important drug target for promoting inflammatory resolution.
Influence of Surface Effect On Nickel Micro Deep Drawing Process
C. Keller,M. Aftenid,M. Banu,A.M. Habraken,E. Hug,S. Castagne,L. Duchene 한국소성가공학회 2010 기타자료 Vol.2010 No.6
In this paper, the forming behavior of nickel sheets is investigated as a function of the number of grains across the thickness by finite element simulations. Experimental tensile tests were carried out on nickel samples of approximately 100 μm grain size and thicknesses ranging between 12.5 μm and 3.2 mm. The decrease of the number of grains across the thickness involves a decrease of tensile stress due to the apparition of surface effects. These latter were taken into account for the deep drawing simulation of samples with 250 μm thickness by the use of two different constitutive elasto-plastic laws for surface and core grains. The simulations with two laws predict a modification of the distribution of the V.M. equivalent stress and of the damage zones compared to results from simulations using a simple average law.
Alterations in cardiac DNA methylation in human dilated cardiomyopathy
Haas, Jan,Frese, Karen S,Park, Yoon Jung,Keller, Andreas,Vogel, Britta,Lindroth, Anders M,Weichenhan, Dieter,Franke, Jennifer,Fischer, Simon,Bauer, Andrea,Marquart, Sabine,Sedaghat-Hamedani, Farbod,Ka WILEY-VCH Verlag 2013 EMBO molecular medicine Vol.5 No.3
<P>Dilated cardiomyopathies (DCM) show remarkable variability in their age of onset, phenotypic presentation, and clinical course. Hence, disease mechanisms must exist that modify the occurrence and progression of DCM, either by genetic or epigenetic factors that may interact with environmental stimuli. In the present study, we examined genome-wide cardiac DNA methylation in patients with idiopathic DCM and controls. We detected methylation differences in pathways related to heart disease, but also in genes with yet unknown function in DCM or heart failure, namely <I>Lymphocyte antigen 75</I> (<I>LY75</I>), <I>Tyrosine kinase-type cell surface receptor HER3</I> (<I>ERBB3</I>), <I>Homeobox B13</I> (<I>HOXB13</I>) and <I>Adenosine receptor A2A</I> (<I>ADORA2A</I>). Mass-spectrometric analysis and bisulphite-sequencing enabled confirmation of the observed DNA methylation changes in independent cohorts. Aberrant DNA methylation in DCM patients was associated with significant changes in <I>LY75</I> and <I>ADORA2A</I> mRNA expression, but not in <I>ERBB3</I> and <I>HOXB13</I>. <I>In vivo</I> studies of orthologous <I>ly75</I> and <I>adora2a</I> in zebrafish demonstrate a functional role of these genes in adaptive or maladaptive pathways in heart failure.</P>
EVOLUTION OF NUCLEAR FUEL MANAGEMENT AND REACTOR OPERATIONAL AID TOOLS
TURINSKY PAUL J.,KELLER PAUL M.,ABDEL-KHALIK HANY S. Korean Nuclear Society 2005 Nuclear Engineering and Technology Vol.37 No.1
In this paper are reviewed the current status of nuclear fuel management and reactor operational aid tools. In addition, we indicate deficiencies in current capabilities and what future research is judged warranted. For the nuclear fuel management review the focus is on light water reactors and the utilization of stochastic optimization methods applied to the lattice, fuel bundle, core loading pattern, and for BWRs the control rod pattern/core flow design decision making problems. Significant progress in addressing separately each of these design problems on a single cycle basis is noted; however, the outstanding challenge of addressing the integrated design problem over multiple cycles under conditions of uncertainty remains to be addressed. For the reactor operational aid tools review the focus is on core simulators, used to both process core instrumentation signals and as an operator aid to predict future core behaviors under various operational strategies. After briefly reviewing the current status of capabilities, a more in depth review of adaptive core simulation capabilities, where core simulator input data are adjusted within their known uncertainties to improved agreement between prediction and measurement, is presented. This is done in support of the belief that further development of adaptive core simulation capabilities is required to further significantly advance the utility of core simulators in support of reactor operational aid tools.
Tailoring the electronic properties of Ca<sub>2</sub>RuO<sub>4</sub> via epitaxial strain
Dietl, C.,Sinha, S. K.,Christiani, G.,Khaydukov, Y.,Keller, T.,Putzky, D.,Ibrahimkutty, S.,Wochner, P.,Logvenov, G.,van Aken, P. A.,Kim, B. J.,Keimer, B. American Institute of Physics 2018 APPLIED PHYSICS LETTERS Vol.112 No.3