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Design, Synthesis In Vitro Anticancer Activity and Docking Studies of (−)-Catechin Derivatives
Deepak Kumar,S. J. Harshavardhan,Sridhar Chirumarry,Y. Poornachandra,장기완,C. Ganesh Kumar,윤용진,Bao-Xiang Zhao,Jun-Ying Miao,신동수 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.2
Novel series of ()-catechin derivatives 1a-l were synthesized, characterized and assayed for their cytotoxicity against four selected human cancer cell lines by standard MTT assay method. Most of the compounds significantly active among which 1d exhibited promising activity with IC50 values of 2.5, 4.8 and 5.4 μM specifically against hepatocellular liver carcinoma (HepG2), lung adenocarcinoma (A549) and prostate (DU-145) cell lines, while compound 1j showed promising cytotoxicity against human breast adenocarcinoma MDA-MB-231 (IC50 value of 6.6 μM). Compounds 1a, 1d, 1e, 1f and 1j exhibited broad spectrum cytotoxicity against all the cell lines screened. Molecular docking studies of compound 1d established the good binding affinity and are in favor of the observed biological activity. These data collectively suggest that compound 1d could serve as a new template for further optimization as anticancer agent.
Deepak Kumar,Sridhar Chirumarry,B. V. D. Vijaykumar,S. J. Harshavardhan,장기완,이동하,신동수 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.4
An efficient synthesis of (3Z,6Z)-cis-9,10-epoxy-3,6-henicosadiene (1), the major component of sex pheromone of saltmarsh caterpillar moth Estigmene acrea (Drury), was accomplished from commercially available pentadec-3-yn-1-ol and bromoundecane. Chirality was introduced by employing Sharpless asymmetric dihydroxylation on cis-olefin intermediate in the synthesis of 1, for the first time. The other key reactions include metal-dissolving coupling, Lindlar's catalyst-assisted partial hydrogenation, one-pot, three-step epoxidation from vicinal diol, and Wittig olefination. The overall yield of 1 was 24.7% in eight steps. The efficiency and simplicity of this synthesis allow the potential use of pheromone 1 in pest management programs.
Synthesis of POSS Derived Organic-Inorganic Hybrid Esters for Insulating Oil Applications
Kyeong-min Choi,S. J. Harshavardhan,Ch. Sridhar,B. V. D. Vijaykumar,Deepak Kumar,장기완,이만식,신동수 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.9
In this work, a new family of polyhedral oligomeric silsesquioxanes (POSS) based esters have been synthesized that consists eight ester functional groups. These are classified into Type-I and Type-II esters based on the starting materials, octakis(3-chloropropyl)silsesquioxane (Cl-POSS) and octakis(3-hydroxypropyldimethylsiloxy) octasilsesquioxane (OHPS) respectively. These new POSS type ester moieties can be used as insulating oils and oil additives in the transformers and also considered to be alternatives to mineral and vegetable oils that are presently used in the insulation system.
Synthesis of POSS Derived Organic-Inorganic Hybrid Esters for Insulating Oil Applications
Choi, Kyeong-Min,Harshavardhan, S.J.,Sridhar, Ch.,Vijaykumar, B.V.D.,Kumar, Deepak,Jang, Kiwan,Lee, Man-Sig,Shin, Dong-Soo Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.9
In this work, a new family of polyhedral oligomeric silsesquioxanes (POSS) based esters have been synthesized that consists eight ester functional groups. These are classified into Type-I and Type-II esters based on the starting materials, octakis(3-chloropropyl)silsesquioxane (Cl-POSS) and octakis(3-hydroxypropyldimethylsiloxy) octasilsesquioxane (OHPS) respectively. These new POSS type ester moieties can be used as insulating oils and oil additives in the transformers and also considered to be alternatives to mineral and vegetable oils that are presently used in the insulation system.