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Thrust estimation of a flapping foil attached to an elastic plate using multiple regression analysis
Rupesh Kumar,Hyun Kyoung Shin 대한조선학회 2019 International Journal of Naval Architecture and Oc Vol.11 No.2
Researchers have previously proven that the flapping motion of the hydrofoil can convert wave energy into propulsive energy. However, the estimation of thrust forces generated by the flapping foil placed in waves remains a challenging task for ocean engineers owing to the complex dynamics and uncertainties involved. In this study, the flapping foil system consists of a rigid NACA0015 section undergoing harmonic flapping motion and a passively actuated elastic flat plate attached to the leading edge of the rigid foil. We have experimentally measured the thrust force generated due to the flapping motion of a rigid foil attached to an elastic plate in a wave flume, and the effects of the elastic plates have been discussed in detail. Furthermore, an empirical formula was introduced to predict the thrust force of a flapping foil based on our experimental results using multiple regression analysis.
Effect of edaravone in diabetes mellitus-induced nephropathy in rats
Varatharajan, Rajavel,Lim, Li Xin,Tan, Kelly,Tay, Chai Sze,Teoh, Yi Leng,Akhtar, Shaikh Sohrab,Rupeshkumar, Mani,Chung, Ivy,Abdullah, Nor Azizan,Banik, Urmila,Dhanaraj, Sokkalingam A.,Balakumar, Pitch The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.4
Edaravone, a synthetic-free radical scavenger, has been reported to reduce ischemia-reperfusion-induced renal injury by improving tubular cell function, and lowering serum creatinine and renal vascular resistance. The present study investigated the effect of edaravone in diabetes mellitus-induced nephropathy in rats. A single administration of streptozotocin (STZ, 55 mg/kg, i .p.) was employed to induce diabetes mellitus in rats. The STZ-administered diabetic rats were allowed for 10 weeks to develop nephropathy. Mean body weight, lipid alteration, renal functional and histopathology were analysed. Diabetic rats developed nephropathy as evidenced by a significant increase in serum creatinine and urea, and marked renal histopathological abnormalities like glomerulosclerosis and tubular cell degeneration. The kidney weight to body weight ratio was increased. Moreover, diabetic rats showed lipid alteration as evidenced by a significant increase in serum triglycerides and decrease in serum high-density lipoproteins. Edaravone (10 mg/kg, i .p., last 4-weeks) treatment markedly prevented the development of nephropathy in diabetic rats by reducing serum creatinine and urea and preventing renal structural abnormalities. In addition, its treatment, without significantly altering the elevated glucose level in diabetic rats, prevented diabetes mellitus-induced lipid alteration by reducing serum triglycerides and increasing serum high-density lipoproteins. Interestingly, the renoprotective effect of edaravone was comparable to that of lisinopril (5 mg/kg, p.o, 4 weeks, standard drug). Edaravone prevented renal structural and functional abnormalities and lipid alteration associated with experimental diabetes mellitus. Edaravone has a potential to prevent nephropathy without showing an anti-diabetic action, implicating its direct renoprotection in diabetic rats.