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- 저자 : Roy P. Yu (검색결과 3 건)
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A Call for a Rational Polypharmacy Policy: International Insights From Psychiatrists
Yukako Nakagami,Kohei Hayakawa,Toru Horinouchi,Victor Pereira-Sanchez,Marcus P,J,Tan,Seon-Cheol Park,Yong Chon Park,Seok Woo Moon,Tae Young Choi,Ajit Avasthi,Sandeep Grover,Roy Abraham Kallivayalil,Yu 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.11
Objective Recently, rational polypharmacy approaches have been proposed, regardless of the lower risk and cost of monotherapy. Considering monotherapy as first-line treatment and polypharmacy as rational treatment, a balanced attitude toward polypharmacy is recommended. However, the high prevalence of polypharmacy led the Japanese government to establish a polypharmacy reduction policy. Based on this, the association between the policy and psychiatrists’ attitude toward polypharmacy has been under debate. Methods We developed an original questionnaire about Psychiatrists’ attitudes toward polypharmacy (PAP). We compared the PAP scores with the treatment decision-making in clinical case vignettes. Multiple regression analyses were performed to quantify associations of explanatory variables including policy factors and PAP scores. The anonymous questionnaires were administered to psychiatrists worldwide. Results The study included 347 psychiatrists from 34 countries. Decision-making toward polypharmacy was associated with high PAP scores. Multiple regression analysis revealed that low PAP scores were associated with the policy factor (β=-0.20, p=0.004). The culture in Korea was associated with high PAP scores (β=0.34, p<0.001), whereas the culture in India and Nepal were associated with low scores (β=-0.15, p=0.01, and β=-0.17, p=0.006, respectively). Conclusion Policy on polypharmacy may influence psychiatrists’ decision-making. Thus, policies considering rational polypharmacy should be established.
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Tissue Expanders in Staged Calvarial Reconstruction: A Systematic Review
Andrea Y. Lo,Roy P. Yu,Anjali C. Raghuram,Michael N. Cooper,Holly J. Thompson,Charles Y. Liu,Alex K. Wong 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.6
Cranioplasties are common procedures in plastic surgery. The use of tissue expansion (TE) in staged cranioplasties is less common. We present two cases of cranioplasties with TE and systematically review literature describing the use of TE in staged cranioplasties and postoperative outcomes. A systematic review was performed by querying multiple databases. Eligible articles include published case series, retrospective reviews, and systematic reviews that described use of TE for staged bony cranioplasty. Data regarding study size, patient demographics, preoperative characteristics, staged procedure characteristics, and postoperative outcomes were collected. Of 755 identified publications, 26 met inclusion criteria. 85 patients underwent a staged cranioplasty with TE. Average defect size was 122 cm2, and 30.9% of patients received a previous reconstruction. Average expansion period was 14.2 weeks. The most common soft tissue closures were performed with skin expansion only (75.3%), free/pedicled flap (20.1%), and skin graft (4.7%). The mean postoperative follow-up time was 23.9 months. Overall infection and local complication rates were 3.53 and 9.41%, respectively. The most common complications were cerebrospinal fluid leak (7.1%), hematoma (7.1%), implant exposure (3.5%), and infection (3.5%). Factors associated with higher complication rates include the following: use of alloplastic calvarial implants and defects of congenital etiology (p¼0.023 and 0.035, respectively). This is the first comprehensive review to describe current practices and outcomes in staged cranioplasty with TE. Adequate soft tissue coverage contributes to successful cranioplasties and TE can play a safe and effective role in selected cases.
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Ji Young Yu,D. P. Roy,I. Schienbein,E. A. Paschos 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.2
We present predictions for the ux averaged muon energy spectra of quasi-elastic (QE) and 1-pion production events for the K2K long-baseline experiment. By using general kinematical considerations, we show that the muon-energy spectra closely follow the neutrino-energy spectrum with downward shift of the energy scale by 0:15 GeV (QE) and 0:4 GeV (1-pion production). These predictions seem to agree with the observed muon energy spectra in the K2K nearby detector. We also show the spectral distortion of these muon energy spectra due to neutrino oscillation for the SK detector. Comparison of the predicted spectral distortions with the observed muon-spectra of the 1-Ring and 2-Ring muon events in the SK detector will help to determine the oscillation parameters. The results will also be applicable to other LBL experiments.
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