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Co-Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle–Aptamer Bioconjugates
Zhang, Liangfang,Radovic-Moreno, Aleksandar F.,Alexis, Frank,Gu, Frank X.,Basto, Pamela A.,Bagalkot, Vaishali,Jon, Sangyong,Langer, Robert S.,Farokhzad, Omid C. WILEY-VCH Verlag 2007 ChemMedChem Vol.2 No.9
<B>Graphic Abstract</B> <P>Herein we report a novel targeted drug delivery system consisting of nanoparticle–aptamer bioconjugates, which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co-delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues. <img src='wiley_img/18607179-2007-2-9-CMDC200700121-content.gif' alt='wiley_img/18607179-2007-2-9-CMDC200700121-content'> </P>
Multilayered Polymer-Coated Carbon Nanotubes To Deliver Dasatinib
Moore, Thomas L.,Grimes, Stuart W.,Lewis, Robert L.,Alexis, Frank American Chemical Society 2014 MOLECULAR PHARMACEUTICS Vol.11 No.1
<P>Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib’s release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mpohbp/2014/mpohbp.2014.11.issue-1/mp400448w/production/images/medium/mp-2013-00448w_0009.gif'></P>