Continuous suture hepaticojejunostomy is economical with similar long term results as interrupted suture technique: An audit of a prospective database of 556 hepaticojejunostomies

Rajan SAXENA,Nalini Kanta GHOSH,Saurabh GALODHA 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-

Mono-segment (segment 2) donor hepatectomy for pediatric liver transplantation

Rajan GARG,Vinayak NIKAM,Anurag SHRIMAL,Prashantha S RAO,Mitul SHAH,Ravi MOHANKA 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-

Relation between heart rate variability and spectral analysis of electroencephalogram in chronic neuropathic pain patients

Rajan John,Gaur Girwar Singh,Shanmugavel Karthik,S Adinarayanan 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.3

Chronic neuropathic pain (CNP) is a complex condition often arising from neural maladaptation after nerve injury. Understanding CNP complications involves the intricate interplay between brain-heart dynamics, assessed through quantitative electroencephalogram (qEEG) and heart rate variability (HRV). However, insights into their interaction in chronic pain are limited. Resting EEG and simultaneous electrocardiogram (lead II) of the participants were recorded for qEEG and HRV analysis. Correlations between HRV and qEEG parameters were calculated and compared with age, sex, and body mass index (BMI)-matched controls. CNP patients showed reduced HRV and significant increases in qEEG power spectral densities within delta, theta, and beta frequency ranges. A positive correlation was found between low frequency/ high frequency (LF/HF) ratio in HRV analysis and theta, alpha, and beta frequency bands in qEEG among CNP patients. However, no significant correlation was observed between parasympathetic indices and theta, beta bands in qEEG within CNP group, unlike age, sex, and BMI-matched healthy controls. CNP patients display significant HRV reductions and distinctive qEEG patterns. While healthy controls exhibit significant correlations between parasympathetic HRV parameters and qEEG spectral densities, these relationships are diminished or absent in CNP individuals. LF/HF ratio, reflecting sympathovagal balance, correlates significantly with qEEG frequency bands (theta, alpha, beta), illuminating autonomic dysregulation in CNP. These findings emphasize the intricate brain-heart interplay in chronic pain, warranting further exploration.

체첸에서의 실패

( Rajan Menon ),( Graham E . Fuller ) 한국민족연구원 2000 민족연구 Vol.0 No.5

N/A

Effect of bilateral infraorbital nerve block on intraoperative anesthetic requirements, hemodynamics, glycemic levels, and extubation in infants undergoing cheiloplasty under general anesthesia

Rajan, Sunil,Mathew, Jacob,Kumar, Lakshmi The Korean Dental Society of Anesthsiology 2021 Journal of Dental Anesthesia and Pain Medicine Vol.21 No.2

Background: Inappropriate use of intravenous and inhaled anesthetics may be dangerous in infants undergoing facial cleft surgeries. This study primarily aimed to compare the effect of infraorbital nerve block on sevoflurane requirement in infants undergoing cheiloplasty. Intraoperative opioid consumption, hemodynamics, blood glucose levels, extubation time, and delirium were also compared. Methods: This prospective, randomized, double-blinded study was conducted in 34 infants undergoing cheiloplasty under general anesthesia. After induction, group A received bilateral infraorbital nerve block with 0.5 mL of 0.5% bupivacaine and group B 0.5 mL saline. An increase in heart rate or blood pressure > 20% was managed by increasing sevoflurane by 2-2.5%, followed by fentanyl 0.5 ㎍/kg bolus. The chi-square test and independent-sample t-test were used where applicable. Results: Demographics, duration of surgery, and intravenous fluids used were comparable between the groups. Compared to group A, patients in group B had significantly higher consumption of fentanyl (14.2 ± 4.4 ㎍ vs. 22.1 ± 6.2 ㎍) and sevoflurane (14.2 ± 4.8 mL vs. 26.8 ± 15.6 mL). Intraoperative hemodynamic parameters were significantly lower in group A, the number of times increases in hemodynamic parameters occurred, and fentanyl supplemental bolus was required remained significantly lower in group A than in group B. Intraoperative glycemic levels remained higher in group B, and the extubation time was significantly shorter in group A than in group B (4.40 ± 1.60 min vs. 9.2 ± 2.18 min). Group A had a lesser occurrence of postoperative delirium. Conclusion: Supplemental infraorbital block in infants undergoing cheiloplasty under general anesthesia resulted in significantly decreased anesthetic requirements and optimal hemodynamic and glycemic levels with faster extubation and lesser delirium.

Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders

( Rajan Singh ),( Hannah Zogg ),( Lai Wei ),( Allison Bartlett ),( Uday C Ghoshal ),( Singh Rajender ),( Seungil Ro ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.1

Of all microorganisms in the human body, the largest and most complex population resides in the gastrointestinal (GI) tract. The gut microbiota continuously adapts to the host environment and serves multiple critical functions for their hosts, including regulating host immunity, procuring energy from food, and preventing the colonization of pathogens. Mounting evidence has suggested gut microbial imbalance (dysbiosis) as a core pathophysiology in the development of GI motility and metabolic disorders, such as irritable bowel syndrome and diabetes. Current research has focused on discovering associations between these disorders and gut microbial dysbiosis; however, whether these associations are a consequence or cause is still mostly unexplored. State-of-the-art studies have investigated how gut microbes communicate with our body systems through microbiota-derived metabolites and how they are able to modulate host physiology. There is now mounting evidence that alterations in the composition of small intestinal microbes have an association with GI dysmotility and metabolic disorders. Although treatment options for gut microbial dysbiosis are currently limited, antibiotics, fecal microbiota transplantation, probiotics, and dietary interventions are currently the best options. However, treatment with broad-spectrum antibiotics has been viewed with skepticism due to the risk of developing antibiotic resistant bacteria. Studies are warranted to elucidate the cellular and molecular pathways underlying gut microbiota-host crosstalk and for the development of a powerful platform for future therapeutic approaches. Here, we review recent literature on gut microbial alterations and/or interactions involved in the pathophysiology of GI dysmotility and metabolic disorders. (J Neurogastroenterol Motil 2021;27:19-34)

Experimental evaluation of waste plastic oil and its blends on a single cylinder diesel engine

Rajan Kumar,M. K. Mishra,S. K. Singh,Arbind Kumar 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.10

The aim of the present work to investigate the performance of oil derived from the waste plastic on diesel engine. Waste plastic fuel (WPF) is derived from the waste plastics by catalytic pyrolysis. Test were employed to completely characterize the Fuel by determining the physical, chemical and spectroscopic like FTIR , GC-MS properties of WPF and WPF-diesel blends in different proportions and to evaluate the performance and emission characteristics of these fuel and their blends on a single cylinder diesel engine and finally the results were compared with reference test fuel diesel. It is observed that the engine can operate with neat WPF and their blends without any modification and can be used as an alternative fuel for diesel engine. However, it is found that WPF10D90 (10% waste plastic oil and 90% diesel fuel) shows similar results as compare to diesel.

Reclamation of Desert with Regular Application of Waste Water

Rajan Raj Pandey 한국데이터전략학회 2024 Journal of information technology applications & m Vol.31 No.4

. Deserts around the world mostly do not have plants and are ever- expanding their area each year. There is shortage of food and prevalent hunger around the world mostly in the African countries that have desert. The waste water is not properly managed in those places and it causes disease outbreaks. So, the problems of desertification, waste water management and hunger have to be addressed by the world community. This thesis work tries to explore a possibility of reclamation of deserts with regular application of waste water. The results obtained from a four months long test are very encouraging and it can be easily concluded that the deserts can be reclaimed by application of waste water and it will relieve the desert community from the burden of costly treatment of waste water as well. In turn, they will, to some extent, get rid of water borne diseases and the reclaimed land could be used in future to produce more food to feed the hungry community- positively impacting directly to food security of the focused community.

A unique scaffold for bone tissue engineering: An osteogenic combination of graphene oxide-hyaluronic acid-chitosan with simvastatin

Rajan Unnithan, A.,Ramachandra Kurup Sasikala, A.,Park, C.H.,Kim, C.S. Korean Society of Industrial and Engineering Chemi 2017 Journal of industrial and engineering chemistry Vol.46 No.-

<P>The present study explores the first ever fabrication of graphene oxide (GO)Chitosan (CS)Hyaluronic acid (HA) based bioactive composite scaffold containing an osteogenesis-inducing drug simvastatin (SV) for bone tissue engineering application. Porosity, density, swelling, degradation and biomineralization studies favored the SV loaded GOCSHA scaffold in comparison to the conventional CS and HA based scaffolds. The in vitro results showed that the SV also offers a significant influence on osteogenesis and biomineralization and it possess excellent biocompatibility to be used as a bone tissue engineering scaffold, which is able to persuade osteogenesis and mineralization. (C) 2016 Published by Elsevier B.V. on behalf of The Korean Society of Industrial and Engineering Chemistry.</P>

Contemplating charge transport by modeling of DNA nucleobases based nano structures

Rajan Vohra,Ravinder Singh Sawhney,Kunwar Partap Singh 한국물리학회 2020 Current Applied Physics Vol.20 No.5

Electrical charge transport through two basic strands Thymine and Adenine of DNA has been analyzed using jellium model approach. The FFT-2D computations have been performed for semi empirical Extended Huckel Theory using Atomistix Tool kit to contemplate the charge transport metrics like current and conductance. We have scrutinized the behavior of the devices in the range of -2 V–2 V for a step size of 0.2 V. A prominent observation is the drop in HLGs of Adenine and Thymine, when working as device as compared to their intrinsic values and this is comparative more visible in case of Adenine. The current in the thymine based device exhibit linear increase with voltage in spite of having low conductance. Further the broader transmission peaks represent the strong coupling of electrodes to the scattering molecule (Thymine). The NDR effect of Adenine based device for higher bias can be utilized in various future electronics applications.