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RISS 인기검색어
- 검색키워드
- 저자 : Rahul Shinde (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
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Normal Values of High-resolution Anorectal Manometry of Healthy Indians
Rahul Deshmukh,Akash Shukla,Sanjay Chandnani,Pravin M Rathi,Pratik Tibdewal,Shubham Jain,Nitin Ramani,Parmeshwar Junare,Partha Debnath,Leela Shinde,Asif Bagwan,Megha Meshram 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3
Background/AimsHigh-resolution anorectal manometry (HRAM) measures anal sphincter function and anorectal co-ordination. This study aims to provide normal data for HRAM and evaluate the effect of gender, age, and body mass index (BMI) on anorectal functions in healthy Indian subjects. MethodsHRAM was performed on 93 healthy volunteers using a 20-channel, water-perfused catheter. We evaluated anorectal pressures, rectal sensation, and balloon expulsion time. Measurements were recorded during rest, squeeze, and simulated defecation (push). ResultsMedian anal resting pressure (88 mmHg vs 94 mmHg, P = NS), anal squeeze pressure (165 mmHg vs 147 mmHg, P = NS) were not significantly different between males and females. Rectal pressure (70 mmHg vs 54 mmHg, P = 0.024) and anal pressure (82 mmHg vs 63 mmHg, P = 0.008) during simulated evacuation without rectal distention, were higher in males. The threshold for the first sensation was lower in females (40 mL vs 30 mL, P = 0.021) but desire to defecate (105 mL vs 90 mL, P = NS) and maximum tolerable volume (160 mL vs 140 mL, P = NS) were not significantly different in males and females. Anal residual pressure (median mmHg 83 vs 71 mmHg, P = 0.025) was higher in subjects < 40 years of age. Maximum anal squeeze pressure (185 mmHg vs 165 mmHg, P = 0.024) and maximum rectal pressure (75 mmHg vs 62 mmHg, P = 0.032) during push higher in BMI < 23 kg/m2. ConclusionsThe present study provides normal data for the Indian population that can be used for comparison and further work. Age, gender, and BMI affect anorectal parameters in HRAM and should be considered while reporting.
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Nagawade, Rahul R.,Shinde, Devanand B. Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.12
Zirconium(IV) chloride is found to be an efficient catalyst for the electrophilic addition reaction of indole with aldehydes/ketones to afford the corresponding bis(indolyl methanes in good yields. The remarkable features of this new procedure are high conversions, shorter reaction times, cleaner reaction profiles and simple experimental and work-up procedures.
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Therapeutic potential of quercetin as a cardiovascular agent
Patel, Rahul V.,Mistry, Bhupendra M.,Shinde, Surendra K.,Syed, Riyaz,Singh, Vijay,Shin, Han-Seung Elsevier 2018 European journal of medicinal chemistry Vol.155 No.-
<P><B>Abstract</B></P> <P>Flavonoids are integral components of various vegetation and in foods; consequently, they represent an inevitable part of the diet. Historical and epidemiological proof recommend that diet plans consisting of flavonoids such as quercetin have positive health benefits, especially on the heart. Flavonoids have been proven to be active against hypertension, inflammation, diabetes and vascular diseases. Quercetin exhibits significant heart related benefits as inhibition of LDL oxidation, endothelium-independent vasodilator effects, reduction of adhesion molecules and other inflammatory markers, the protective effect on nitric oxide and endothelial function under conditions of oxidative stress, prevention of neuronal oxidative and inflammatory damage and platelet antiaggregant effects. Searching for experimental evidence to validate the cardioprotective effects of quercetin, we review here the recent detailed <I>in vivo</I> studies. Quercetin and its derivatives lead to an enhancement in heart features, indicating the prospective for quercetin to be used therapeutically in the treatment of cardiac diseases. Several evidence-based studies suggest mechanisms to observe cardiovascular diseases such as aging effects, hypertension, angiotensin-converting enzyme activity and endothelial-dependent and independent functions. Different animal models including human are also used to elucidate the <I>in vivo</I> role of quercetin in cardiovascular diseases. The role of quercetin and its derivatives may go beyond their existence in food and has potential as a lead molecule in drug development programs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Quercetin is a popular dietary anti-oxidant present in numerous vegetables and fruits, tea, and wine. </LI> <LI> Chemically, quercetin is a kind of flavonoid that particularly belongs to the flavonols group. </LI> <LI> The numerous cardioprotective activities of quercetin has been discussed. </LI> <LI> Quercetin protects against atherosclerosis, oxidative stress, cardiotoxicity, endothelial cell dysfunction, heart failure etc. </LI> <LI> Quercetin has potential as a lead molecule in drug development programs for cardiovascular diseases. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P> <I>In vivo</I> evidences for the cardio-protective functions of a natural compound quercetin have been reviewed.</P> <P>[DISPLAY OMISSION]</P>
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Devanand B. Shinde,Rahul R. Nagawade 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.12
Zirconium(IV) chloride is found to be an efficient catalyst for the electrophilic addition reaction of indole with aldehydes/ketones to afford the corresponding bis(indolyl)methanes in good yields. The remarkable features of this new procedure are high conversions, shorter reaction times, cleaner reaction profiles and simple experimental and work-up procedures
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Potential of Cranberry Powder for Management of Hyperglycemia Using In Vitro Models
Marcia da Silva Pinto,Reza Ghaedian,Rahul Shinde,Kalidas Shetty 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.5
Aqueous solutions of two different cranberry powders (CP and CP-SAB) were evaluated for organic acids, sugars, total phenolics, antioxidant activity based on the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay, and functionality such as in vitro inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potential management of hyperglycemia and hypertension linked to type 2 diabetes. The total phenolics content was 11 and 51mg/g of sample dry weight for CP and CP-SAB, respectively. p-Coumaric acid and quercetin derivatives were the main phenolic compounds identified in the cranberry powders. CP-SAB had α-glucosidase inhibitory activity that increased with increased dose (1–5mg/mL) from 60% to 100% inhibition. There was limited amount of α-amylase inhibitory activity that reached a maximum of 40% inhibition at 5mg/mL treatment. Significant ACE inhibitory activity was detected for CP-SAB at 100 and 200mg/mL sample concentrations. These in vitro results indicate the potential of cranberry powders as dietary supplement and food-based strategies for potential hyperglycemia management. This biochemical rationale provides the basis for further design of animal and clinical studies using standardized extracts.
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