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A. Eckert,R. Neugebauer,M. Rossinger,M. Wahl,F. Schulz 한국소성가공학회 2011 기타자료 Vol.2011 No.8
This paper deals with the determination of application limits of an already presented method [1] to predict distortion of joined car body assemblies caused by mechanical joining technologies. The investigated method is particularly developed concerning the demands coming from the application in the automotive body production. Parameter studies in simulation and experiment are presented which show the influence of pre-straining and clamping on the joints properties and dimensional accuracy of the assembly. The gained cognitions allow conclusions about the quality of prediction of dimensional accuracy using the proposed simplified model in different joining situations. Finally, the investigated method is applied to a car body assembly.
Korean Red Ginseng extract treatment prevents post-antibiotic dysbiosis-induced bone loss in mice
Ho Jun Kang,Nicholas Chargo,Soumya Chennupati,Kerri Neugebauer,Jae Youl Cho,Robert Quinn,Laura R. McCabe,Narayanan Parameswaran The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2
Background: The intestinal microbiota is an important regulator of bone health. In previous studies we have shown that intestinal microbiota dysbiosis, induced by treatment with broad spectrum antibiotics (ABX) followed by natural repopulation, results in gut barrier dysfunction and bone loss. We have also shown that treatment with probiotics or a gut barrier enhancer can inhibit dysbiosis-induced bone loss. The overall goal of this project was to test the effect of Korean Red Ginseng (KRG) extract on bone and gut health using antibiotics (ABX) dysbiosis-induced bone loss model in mice. Methods: Adult male mice (Balb/C, 12-week old) were administered broad spectrum antibiotics (ampicillin and neomycin) for 2 weeks followed by 4 weeks of natural repopulation. During this 4-week period, mice were treated with vehicle (water) or KRG extract. Other controls included mice that did not receive either antibiotics or KRG extract and mice that received only KRG extract. At the end of the experiments, we assessed various parameters to assess bone, microbiota and in vivo intestinal permeability. Results: Consistent with our previous results, post-ABX- dysbiosis led to significant bone loss. Importantly, this was associated with a decrease in gut microbiota alpha diversity and an increase in intestinal permeability. All these effects including bone loss were prevented by KRG extract treatment. Furthermore, our studies identified multiple genera including Lactobacillus and rc4-4 as well as Alistipes finegoldii to be potentially linked to the effect of KRG extract on gut-bone axis. Conclusion: Together, our results demonstrate that KRG extract regulates the gut-bone axis and is effective at preventing dysbiosis-induced bone loss in mice.
Yao, M.J.,Dey, P.,Seol, J.B.,Choi, P.,Herbig, M.,Marceau, R.K.W.,Hickel, T.,Neugebauer, J.,Raabe, D. Elsevier Science 2016 Acta materialia Vol.106 No.-
<P>We report on the investigation of the off-stoichiometry and site-occupancy of kappa-carbide precipitates within an austenitic (gamma), Fe-29.8Mn-7.7Al-1.3C (wt.%) alloy using a combination of atom probe tomography and density functional theory. The chemical composition of the kappa-carbides as measured by atom probe tomography indicates depletion of both interstitial C and substitutional Al, in comparison to the ideal stoichiometric L'12 bulk perovskite. In this work we demonstrate that both these effects are coupled. The off-stoichiometric concentration of Al can, to a certain extent, be explained by strain caused by the kappa/gamma mismatch, which facilitates occupation of Al sites in kappa-carbide by Mn atoms (Mn-Al(gamma) anti-site defects). The large anti-site concentrations observed by our experiments, however, can only be stabilized if there are C vacancies in the vicinity of the anti-site. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</P>