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Pin1 is required for ultraviolet A-stimulated cyclooxygenase-2 induction in mouse epidermal cells
Quyen, B.T.,Choi, H.K.,Kang, K.W. Elsevier ; Elsevier Science Pub. Co 2013 Cancer letters Vol.335 No.1
Ultraviolet A (UVA) radiation (320-400nm) is considered a major cause of human skin photoaging and skin cancer. Overexpression of cyclooxygenase-2 (COX-2) leads to prostanoid formation in skin tissue, disturbs the balance between proliferation and apoptosis, and subsequently promotes tumorigenesis. The peptidyl-prolyl isomerase Pin1 is known to be overexpressed in most cancer cell types and plays an important role in oncogenesis. Here, we studied whether exposure of JB6 Cl41 mouse epidermal cells to UVA affects COX-2 expression and the possible involvement of Pin1 activation. UVA increased COX-2 protein expression and prostaglandin E2 production in an energy-dependent manner. Pre-exposure of JB6 Cl41 cells to UVA potentiated epidermal growth factor-induced anchorage-independent growth; this effect was significantly suppressed by inhibition of COX-2. UVA-stimulated COX-2 expression was significantly decreased by inhibition of Pin1. The increased COX-2 gene transcription in response to UVA was preceded by activation of the transcription factors nuclear factor-κB (NF-κB), cAMP response element-binding protein (CREB), CCAAT/enhancer-binding proteins α and β (C/EBPα and C/EBPβ) and c-Jun/activator protein-1 (AP-1). Pin1 inhibitor treatment suppressed the activation of NF-κB, CREB, and C/EBP by UVA irradiation. Conversely, JB6 C141 cells overexpressing Pin1 showed increased basal COX-2 expression and NF-κB, CREB, C/EBP, and AP-1 activities. These results suggest that UVA-induced COX-2 expression is mediated by Pin1 activation and this is associated with malignant transformation of epidermal cells.
Quyen Thi Tran, Jung-woo Chae 忠南大學校 醫藥品開發硏究所 2021 藥學論文集 Vol.36 No.-
Clevudine (CLV) and entecavir (ETV) were approved in Korea in 2006. While ETV is recommended as first-line monotherapies for treatment chronic hepatitis B in many countries, the application of CLV is limited in Korea and Philippine due to concern about CLV-induced myopathy. Our meta-analysis study was performed to compare the efficacy and safety of CLV to ETV based on literature reviews. Electronic databases were searched and four studies with a total of 697 patients were included in our study. Results showed that virological re- sponse at 48 weeks of treatment was not significantly different between CLV and ETV (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%). The result for alanine aminotransferase normalization rate (RR: 1.05, 95% CI: 0.96-1.14, I2 = 0%) and serological response (RR: 0.59, 95% CI: 0.27-1.29, I2 = 57%) also showed a similar between CLV and ETV. The results at 24 weeks showed no statistically significant difference between CLV and ETV as well. These results suggest that CLV may have similar efficacy as ETV.
Viscous heating and temperature profiles of liquid water flows in copper nanochannel
Quyen Van Dinh,Truong Quoc Vo,김보흥 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.7
Understanding nanoscale fluidic transport becomes increasingly important due to the rapid development of nanotechnology and nanofabrication. By using molecular dynamics (MD) simulations, we investigated the viscous heating of water flows in copper nanochannels. The two scenarios that were studied are Couette flows and Poiseuille flows. We observed the scale effects on the distribution of fluid density, streaming velocity, fluid viscosity, and temperature across the channel. The results revealed the significant effects of surface forces on causing a large deviation between simulation results and classical hypothesis. We found that the energy equation coupled with the thermal-slip boundary conditions still fails to predict the temperature distributions. Hereby, further scale effects are taken into account, which leads to better predictions. The model that we developed in this study shows the relative deviation to the simulation data within 5 %, which is small compared to the conventional continuum approach (i.e., up to 51 %).
The Role of Semantic Features on the L2 Acquisition of English Articles
Quyen Nguyen 한국중원언어학회 2017 언어학연구 Vol.0 No.45
This study examines the role of semantic features associated with the English article system, namely presuppositionality and specificity, in the acquisition of English articles by Vietnamese L2 learners. Specifically, the study aims to determine whether the Vietnamese L2 learners of English overuse the with specific indefinites and presuppositional indefinites and how the overuse changes depending on contexts and the learners’ proficiency level. Using a forced choice elicitation task, the study has yielded two significant contributions. Firstly, it was found that the learners were affected by both semantic factors as manifested in the overusing of the with specific and presuppositional indefinites. Secondly, the effects of two factors were not equal, with presuppositionality having a stronger and more persistent effect than specificity in triggering article misuses. From the findings, it was suggested that instead of associating the with definiteness, L2 learners often mistakenly associate the with specificity and presuppositionality. Such findings put forward some important pedagogical implications for L2 learners and instructors as well.
Quyen Le Hoang Thuy To NGUYEN,Du Van NGUYEN,Ngoc Nguyen Mong CHU,Van Hong TRAN 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.11
The shift from elite education to mass education in Vietnam has met the demand for education for everybody as well as for quality human resource talent for an emerging nation. Under the resource constraint, understanding the quality dimensions of education and its priority level is important for effective and efficient policies. This study was carried out using both qualitative and quantitative methodologies to develop quality criteria and a ranking model. Two rounds of in-depth interviews were conducted with fifteen experts in the field, who were rectors, employers, and recruitment specialists to develop the quality framework applied in Vietnamese universities under total quality management (TQM), starting from the input of the senior secondary school leavers, through a teaching process to the output. The first round of interviews were unstructured questionnaires designed to explore the main factors in quality assessment model. The second round affirmed the experts’ agreement on the assessment model. Then, fuzzy logic was applied to rank eight criteria in the quality assessment model into priority order: cost, teaching and administrative staff, leadership, curriculum, student-related factors, internationalization, admissions, and campus. The results are critical for identifying the necessary actions to enhance the education quality and to further research on the optimal quality model.
Multi-Carrier Differential Chaos-Shift Keying with Repeated Spreading Sequence
Quyen, Nguyen Xuan The Korean Institute of Communications and Informa 2018 Journal of communications and networks Vol.20 No.3
This paper proposes a multi-carrier differential chaos-shift keying (MC-DCSK) system using repeated spreading sequence (RSS), namely RSS-MC-DCSK, for chaos-based wireless communications. In the proposed system, instead of transmitting the chaotic spreading sequence on a predefined subcarrier as in conventional MC-DCSK, a DCSK-modulated signal, of which each two-bit duration consisting of reference and data-bearing sequences is sent via this subcarrier. Meanwhile, a repeated spreading sequence is produced by copying the reference sequence of the DCSK-modulated signal to the same and next bit periods. The parallel bit streams are multiplied with this RSS and the resulting signals are then conveyed by corresponding subcarriers. In the receiver, the signal retrieved from the predefined subcarrier is DCSK-demodulated and simultaneously used to recover the repeated spreading sequence. The correlative demodulation is performed for all the signals retrieved from the remaining subcarriers to decode the data. The structure and operation of the proposed system are described. Bit error rate (BER) performance under a multipath Rayleigh fading channel is theoretically analyzed and then verified by numerical simulations. In addition, the BER performance, energy and spectral efficiencies of RSS-MC-DCSK are evaluated in comparison to those of MC-DCSK.