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Microstructure and Wear Resistance of in situ Porous TiO/Cu Composites
Qingdong Qin,Bowei Huang,Wei. Li 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.4
An in situ porous TiO/Cu composite is successfully prepared using powder metallurgy by the reaction of Ti2CO and Cu powder. Morphological examination of the composite shows that the porosity of composites lies in the range between 10.2% and 35.2%. Dry sliding un-lubricated wear tests show that the wear resistance of the composite is higher than that of the Cu-Al alloy ingot. The coefficient of friction test shows that, as the volume fraction of the reinforced phase increases, the coefficient of friction decreases. The wear rate variation trend of the oil-lubricated wear test results is similar to that of the un-lubricated wear test results. The coefficient of friction for oil lubrication is similar for different volume fractions of the reinforced phase. The wear resistance of the composite at a sliding velocity of 200 rpm is slightly larger than that at 50 rpm. The porosity of the composites enhances the high-velocity oil-lubricated sliding wear resistance.
Integrated Guidance and Control Design based on a Reference Model
Jian Chen,Qingdong Li,Cunjia Liu,Peng Li,Zhang Ren 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.5
In this paper, an Integrated Guidance and Control (IGC) algorithm based on a reference model is proposedfor a side-jet missile. First, a IGC structure is introduced, incorporating the response characteristics of the missilecontrol loop into the guidance loop. To describe the response characteristics, then a reference model is built. Next,with the back stepping scheme and sliding mode control algorithm, the reference model is adopted to derive a novelguidance law, which contains response parameters of missile control system to formulate the IGC design. Finally,simulations and comparisons with the time-scale separation design and an existing IGC design, are conducted toverify the proposed IGC algorithm. It can be shown that the proposed algorithm performs better against highlymaneuvering target in different missile-target initial position and heading scenarios.
Zhiyan Liu,Dongge Liu,Bowen Ma,Xiaofang Zhang,Peng Su,Li Chen,Qingdong Zeng 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.6
Cytology in China developed from nothing and underwent a long journey from gynecologic cytology to that of all organs, laying a solid foundation for new developments in the 21st century. Thyroid fine-needle aspiration (FNA) was primarily developed in an endocrinology department and then in the clinical laboratory department or pathology department in the 1970–80s. Wrights staining is popular in endocrine and clinical laboratory departments, while hematoxylin and eosin staining is common in pathology. Liquid based cytology is not common in thyroid FNA cytology, while BRAFV600E mutation analysis has been the most popular molecular test. The history and practice of thyroid FNA practice in China were reviewed based on retrospective study of the practice in Qilu Hospital of Shandong University.
Fei Xiaowei,Dou Ya-nan,Sun Kai,Wei Jialiang,Guo Qingdong,Wang Li,Wu Xiuquan,Lv Weihao,Jiang Xiaofan,Fei Zhou 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The tripartite motif (TRIM) 22 and mitogen-activated protein kinase (MAPK) signaling pathways play critical roles in the growth of glioblastoma (GBM). However, the molecular mechanism underlying the relationship between TRIM22 and MAPK signaling remains unclear. Here, we found that TRIM22 binds to exon 2 of the sphingosine kinase 2 (SPHK2) gene. An ERK1/2-driven luciferase reporter construct identified TRIM22 as a potential activator of MAPK signaling. Knockout and overexpression of TRIM22 regulate the inhibition and activation of MAPK signaling through the RING-finger domain. TRIM22 binds to Raf-1, a negative regulator of MAPK signaling, and accelerates its degradation by inducing K48-linked ubiquitination, which is related to the CC and SPRY domains of TRIM22 and the C1D domain of Raf-1. In vitro and in vivo, an SPHK2 inhibitor (K145), an ERK1/2 inhibitor (selumetinib), and the nonphosphorylated mutant Raf-1S338A inhibited GBM growth. In addition, deletion of the RING domain and the nuclear localization sequence of TRIM22 significantly inhibited TRIM22-induced proliferation of GBM cells in vivo and in vitro. In conclusion, our study showed that TRIM22 regulates SPHK2 transcription and activates MAPK signaling through posttranslational modification of two critical regulators of MAPK signaling in GBM cells.