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RISS 인기검색어
- 검색키워드
- 저자 : Praveen Rai (검색결과 4 건)
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Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling
Praveen Rai,Drista Sharma,Rani Soni,Nazia Khatoon,Bhaskar Sharma,Tarun Kumar Bhatt 한국미생물학회 2017 The journal of microbiology Vol.55 No.4
Malaria has been present since ancient time and remains amajor global health problem in developing countries. Plasmodiumfalciparum belongs to the phylum Apicomplexan,largely contain disease-causing parasites and characterizedby the presence of apicoplast. It is a very essential organelleof P. falciparum responsible for the synthesis of key moleculesrequired for the growth of the parasite. Indispensablenature of apicoplast makes it a potential drug target. Calciumsignaling is important in the establishment of malaria parasiteinside the host. It has been involved in invasion and egressof merozoites during the asexual life cycle of the parasite. Calcium signaling also regulates apicoplast metabolism. Therefore,in this review, we will focus on the role of apicoplast inmalaria biology and its metabolic regulation through Ca++signaling.
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Rai, Prabhakar,Khan, Rizwan,Raj, Sudarsan,Majhi, Sanjit Manohar,Park, Kyung-Kuen,Yu, Yeon-Tae,Lee, In-Hwan,Sekhar, Praveen Kumar The Royal Society of Chemistry 2014 Nanoscale Vol.6 No.1
Au@Cu2O core-shell nanoparticles (NPs) were synthesized by a solution method at room temperature and applied for gas sensor applications. Transmission electron microscopy (TEM) images showed the formation of Au@Cu2O core-shell NPs, where 12-15 nm Au NPs were covered with 60-30 nm Cu2O shell layers. The surface plasmon resonance (SPR) peak of Au NPs was red-shifted (520-598 nm) after Cu2O shell formation. The response of Au@Cu2O core-shell NPs was higher than that of bare Cu2O NPs to CO at different temperatures and concentrations. Similarly, the response of Au@Cu2O core-shell NPs was higher than that of bare Cu2O NPs for NO2 gas at low temperature. The improved performance of Au@Cu2O core-shell NPs was attributed to the pronounced electronic sensitization, high thermal stability and low screening effect of Au NPs.
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Effect of Mandibular Advancement Splint on Obstructive Sleep Apnea with Insulin Resistant Diabetes
Ashutosh Gupta,Arvind Tripathi,Praveen Rai,Piyush Sharma,Vijay Yadav,Dewanshu Kumar 대한수면연구학회 2020 Journal of sleep medicine Vol.17 No.1
Objectives: Obstructive Sleep apnea (OSA) is characterized by complete or partial obstruction of upper airflow despite the effort to breathe, leading to hypoxemia and hypercapnia. The resultant apnea causes sleep fragmentation, which in turn increases sympathetic activity, decreases insulin sensitivity and glucose uptake, and stimulates hepatic gluconeogenesis that ultimately leads to type 2 diabetes. Most studies exploring the effect of continuous positive airway pressure on insulin sensitivity have showed a positive effect. However, there is no evidence on the effect of mandibular advancement device on insulin resistance (IR). This study was aimed to evaluate the effect of mandibular advancement splint (MAS) on IR in patients with OSA. Methods: The present study was conducted at Department of Prosthodontics, Dental College Azamgarh, from June 2015 to July 2017. Sixty eight dentulous patients with type 2 diabetes and mild to moderate OSA and with stable diabetic regimen were included in the study. A MAS was fabricated and fixed at 70% of the maximum mandibular protrusion recorded. Patients that were comfortable with MAS after one month were assessed for apnea-hypopnea index, mean oxygen saturation, and IR at baseline, 6 months, and 1 year after wearing MAS. Results: An improvement in insulin sensitivity was observed at 6 months for mild OSA patients (p=0.001). For moderate OSA patients, no significant improvement was observed following MAS use (p>0.05). Conclusions: The finding suggested that MAS is effective in improving IR in mild OSA patients.
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Morphotectonic analysis of Sheer Khadd River basin using geospatial tools
Ankit Sharma,Prafull Singh,Praveen Kumar Rai 대한공간정보학회 2018 Spatial Information Research Vol.26 No.4
In the present study, a quantitative morphotectonic analysis of Sheer Khadd River basin has been carried out based on geomorphic and morphometric indices such as hypsometric integral, drainage basin asymmetry, mountain front sinuosity, basin elongation ratio, valley floor width to valley height ratio, river sinuosity and stream length gradient index using ASTER digital elevation model (DEM) and Google Earth images to understand the morphotectonics of the basin. The results indicate that Sheer Khadd River basin is tilting towards east and is elongated in shape due to active faulting and folding activity in the terrain. A moderate hypsometric integral value indicates that the basin is still under mature stage of erosion and reflecting a complexity in topography. Fluctuations in stream length gradient index over fault zones indicate irregularities in the drainage course due to the presence of fluvial knick points. The results of morphotectonic and morphometric analysis using DEM data is useful tool for morphotectonic evaluation of any complex terrain.
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