Ocular Manifestations of Venomous Snake Bite over a One-year Period in a Tertiary Care Hospital

Praveen Kumar K V,Praveen Kumar S,Nirupama Kasturi,Shashi Ahuja 대한안과학회 2015 Korean Journal of Ophthalmology Vol.29 No.4

Purpose: Ocular manifestations in snake-bite injuries are quite rare. However, the unusual presentations, diagnosis and their management can pose challenges when they present to the ophthalmologist. Early detection of these treatable conditions can prevent visual loss in these patients who are systemically unstable and are unaware of their ocular condition. To address this, a study was conducted with the aim of identifying the various ocular manifestations of snake bite in a tertiary care center. Methods: This is a one-year institute-based prospective study report of 12 snake bite victims admitted to a tertiary hospital with ocular manifestations between June 2013 to June 2014, which provides data about the demographic characteristics, clinical profiles, ocular manifestations, and their outcomes. Results: Twelve cases of snake bite with ocular manifestations were included of which six were viper bites, three were cobra bites and three were unknown bites. Six patients presented with bilateral acute angle closure glaucoma (50%), two patients had anterior uveitis (16.6%) of which one patient had concomitant optic neuritis. One patient had exudative retinal detachment (8.3%), one patient had thrombocytopenia with subconjunctival hemorrhage (8.3%) and two patients had external ophthalmoplegia (16.6%). Conclusions: Bilateral angle closure glaucoma was the most common ocular manifestation followed by anterior uveitis and external ophthalmoplegia. Snake bite can result in significant ocular morbidity in a majority of patients but spontaneous recovery with anti-snake venom, steroids and conservative management results in good visual prognosis.

Bilateral Acute Anterior Uveitis and Optic Disc Edema Following a Snake Bite

Praveen K Kumar,Shashi Ahuja,Praveen S Kumar 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.2

The authors wish to report a case of bilateral acute anterior uveitis and optic disc edema following ahemotoxic snake bite, in order to highlight the concomitant occurrence of these conditions and the potentialadverse effects of anti-snake venom (ASV). A 35-year-old male was bitten by a viper at seventeen thirtyhours, and was started on ASV. Two days following treatment he experienced sudden onset redness andpainful diminution of vision in both eyes (OU). On examination, the patient’s visual acuity (VA) in OU was 20/ 200. Examination revealed fresh keratic precipitates, cells, and flare in the anterior chamber (AC), posteriorsynechiae, sluggish and ill-sustained pupillary reaction, and hyperemic, edematous disc with blurredmargins in OU. He was started on topical steroids, cycloplegics and intravenous methylprednisolone. Following treatment, the patient showed improvement and was continued on topical medications and oralprednisolone tapered over 3 weeks, after which VA OU improved, the AC showed no cells and flare anddisc edema resolved. Uveitis and optic disc edema in snake bite can either be due to the direct toxic effectsof the venom or the effect of ASV. Steroids have a beneficial role in the management of these symptoms.

Novel Spectrally Efficient UWB Pulses Using Zinc and Frequency-Domain Walsh Basis Functions

Praveen Chaurasiya,Ashkan Ashrafi,Santosh Nagaraj 한국전자통신연구원 2013 ETRI Journal Vol.35 No.3

In this paper, two sets of spectrally efficient ultrawideband (UWB) pulses using zinc and frequency-domain Walsh basis functions are proposed. These signals comply with the Federal Communications Commission (FCC) regulations for UWB indoor communications within the stipulated bandwidth of 3.1 GHz to 10.6 GHz. They also demonstrate high energy spectral efficiency by conforming more closely to the FCC mask than other UWB signals described in the literature. The performance of these pulses under various modulation techniques is discussed in this paper, and the proposed pulses are compared with Gaussian monocycles in terms of spectral efficiency, autocorrelation, crosscorrelation, and bit error rate performance.

Potential use of waste rubber shreds in drainage layer of landfills - An experimental study

Praveen, V.,Sunil, B.M. Techno-Press 2016 Advances in environmental research Vol.5 No.3

Laboratory tests were conducted to evaluate the performance of waste rubber shreds in leachate collection layer of engineered landfills. The study found that waste rubber shreds layer in combination with a gravel layer can be of potential use in landfill drainage system. To study the performance, conventional gravel along with waste rubber shreds were used in different combinations (with total layer thickness = 500 mm) as leachate collection media. For the laboratory study poly vinyl chloride (PVC) pipes were used. The size range of waste rubber shreds used were 25 mm to 75 mm in length and width = 10 to 20 mm. The gravel size used in the leachate collection media is 10 mm to 20 mm size. Performance study of 7 Test Cols. with different combinations of waste rubber shreds and gravel bed thickness were studied to find out the best combination. The study found that the Test Col.-3 having waste rubber shreds thickness = 200 mm and gravel layer thickness = 300 mm gave the best results in terms of percentage removal in various physicochemical parameters present in the leachate. Further to find the best size rubber shreds three more Test Cols - 8, 9 and 10 were constructed having the rubber shreds and gravel layer ratio same as that of Test Col.-3 but having rubber shreds width = 10 mm, 15 mm and 20 mm respectively. Based on the results obtained using Test Cols. 8, 9 and 10 the study found that smaller size rubber shreds gave bests results in terms of improvement in various leachate parameters.

Meta-Model based Optimization and Spring-back Analysis of Sheet Metal Forming

Praveen Kumar(프라빈쿠마르),Seoksoon Lee(이석순) 항공우주시스템공학회 2016 항공우주시스템공학회 학술대회 발표집 Vol.2016 No.11

Certain fractional integral inequalities associated with pathway fractional integral operators

Praveen Agarwal,최준상 대한수학회 2016 대한수학회보 Vol.53 No.1

During the past two decades or so, fractional integral inequalities have proved to be one of the most powerful and far-reaching tools for the development of many branches of pure and applied mathematics. Very recently, many authors have presented some generalized inequalities involving the fractional integral operators. Here, using the pathway fractional integral operator, we give some presumably new and potentially useful fractional integral inequalities whose special cases are shown to yield corresponding inequalities associated with Riemann-Liouville type fractional integral operators. Relevant connections of the results presented here with those earlier ones are also pointed out.

Application of Genetic Algorithm in Software Testing

Praveen Ranjan Srivastava,Tai-hoon Kim 보안공학연구지원센터 2009 International Journal of Software Engineering and Vol.3 No.4

In vitro and in vivo evaluation of gastro-retentive carvedilol loaded chitosan beads using Gastroplus(TM)

Praveen, R.,Prasad Verma, P.R.,Venkatesan, J.,Yoon, D.H.,Kim, S.K.,Singh, S.K. ELSEVIER 2017 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.102 No.-

The objective of present investigation was to develop gastro-retentive controlled release system of carvedilol using biological macromolecule, chitosan. 3<SUP>2</SUP> full factorial design was adopted for optimization of tripolyphosphate (X<SUB>1</SUB>) and curing time (X<SUB>2</SUB>). Bead stability in 0.1N HCl, buoyancy duration, density, drug loading, dissolution efficiency and cumulative percentage release at 8th hour were evaluated as dependent variables. The levels of X<SUB>1</SUB> and X<SUB>2</SUB> of optimized formulation having maximum desirability was found to 2.0% w/v and 62.66min, respectively. The in silico predicted responses and observed response were found to be in good agreement (percent bias error: -13.295 to +13.269). SEM images showed numerous pores in the cross sectional image that renders buoyancy. AUC<SUB>0-~</SUB> of optimized formulation was 1.47 times higher as compared to suspension corroborating enhanced extent of absorption. T<SUB>max</SUB> and mean residence time were significantly higher from optimized formulation vis a vis suspension. In silico study indicated maximum regional absorption from the duodenum (94.1%) followed by jejunum (5.6%). Wagner-Nelson and Loo-Reigelman method were the preferred deconvolution approach over numerical deconvolution to establish IVIVC. In conclusion, the study showed that gastro-retentive controlled release system prepared using chitosan could be a potential drug carrier of carvedilol with improved bioavailability.

Hepatoprotective activity of terpenoids and terpenoid fractions of Scoparia dulcis L

Praveen Thaggikuppe Krishnamurthy,Jitendra Bajaj,Abhishek Sharma,Sellappan Manimaran,Prashantha Kumar Bommenahalli Ravanappa,Vijayan Pottekad 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.4

Scoparia dulcis L. is widely used in the traditional system of medicine for treating liver ailments. In the present study the terpenoids and terpenoid fractions isolated from 1:1:1 petroleum ether,diethyl ether and methanol (PDM) extract of Scoparia dulcis L. were tested for their in vitro 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Selected samples from the assay were further tested for their in vitro hepatoprotective activity against CCl4 induced hepatotoxicity in freshly isolated rat hepatocytes. In the in vitro antioxidant study, fractions 7, 11, 13, 14, and 15and PDM extract show the DPPH radical scavenging activity. The phytochemical screening of all these fractions show the presence of terpenoids. In the in vitro hepatoprotective study all these fractions and the PDM extract significantly prevent the CCl4 induced changes in the aspartate aspartate amino transferase, alanine amino transferase and alkaline phosphatase levels (p < 0.05). The above results are comparable with the standard, silymarin. The results of the study indicate that, the PDM extract of Scoparia dulcis L. possesses potential hepatoprotective activity and this may be attributed to its free radical scavenging potential, which in turn may be attributed to the presence of terpenoids.

A radial point interpolation method for 1D contaminant transport modelling through landfill liners

Praveen Kumar, R.,Dodagoudar, G.R. Techno-Press 2010 Geomechanics & engineering Vol.2 No.2

In the framework of meshfree methods, a new methodology is developed based on radial point interpolation method (RPIM). This methodology is applied to a one-dimensional contaminant transport modelling in the saturated porous media. The one-dimensional form of advection-dispersion equation involving reactive contaminant is considered in the analysis. The Galerkin weak form of the governing equation is formulated using 1D meshfree shape functions constructed using thin plate spline radial basis functions. MATLAB code is developed to obtain the numerical solution. Numerical examples representing various phenomena, which occur during migration of contaminants, are presented to illustrate the applicability of the proposed method and the results are compared with those obtained from the analytical and finite element solutions. The proposed RPIM has generated results with no oscillations and they are insensitive to Peclet constraints. In order to test the practical applicability and performance of the RPIM, three case studies of contaminant transport through the landfill liners are presented. A good agreement is obtained between the results of the RPIM and the field investigation data.