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Khoi, Pham Ngoc,Xia, Yong,Lian, Sen,Kim, Ho Dong,Kim, Do Hyun,Joo, Young Eun,Chay, Kee-Oh,Kim, Kyung Keun,Jung, Young Do Lychnia 2014 International journal of oncology Vol.45 No.4
<P>Cadmium exposure has been linked to human cancers, including stomach cancer. In this study, the effects of cadmium on urokinase-type plasminogen activator receptor (uPAR) expression in human gastric cancer cells and the underlying signal transduction pathways were investigated. Cadmium induced uPAR expression in a time- and concentration-dependent manner. Cadmium also induced uPAR promoter activity. Additionally, cadmium induced the activation of extracellular signal regulated kinase-1/2 (ERK-1/2), p38 mitogen-activated protein kinase (MAPK), and the activation of c-Jun amino terminal kinase (JNK). A specific inhibitor of MEK-1 (PD98059) inhibited cadmium-induced uPAR expression, while JNK and p38 MAPK inhibitors did not. Expression vectors encoding dominant-negative MEK-1 (pMCL-K97M) also prevented cadmium-induced uPAR promoter activity. Site-directed mutagenesis and electrophoretic mobility shift studies showed that sites for the transcription factors nuclear factor (NF)-kappa B and activator protein-1 (AP-1) were involved in cadmium-induced uPAR transcription. Suppression of the cadmium-induced uPAR promoter activity by a mutated-type NF-kappa B-indncing kinase and I-kappa B and an AP-1 decoy oligonucleotide confirmed that the activation of NF-kappa B and AP-1 are essential for cadmium-induced uPAR upregulation. Cells pretreated with cadmium showed markedly enhanced invasiveness and this effect was partially abrogated by uPAR-neutralizing antibodies and by inhibitors of ERK-1/2, NF-kappa B, and AP-1. These results suggest that cadmium induces uPAR expression via ERK-1/2, NF-kappa B, and AP-1 signaling pathways and, in turn, stimulates cell invasiveness in human gastric cancer AGS cells.</P>
Phung Bao Ngoc,Nguyen Khoi Viet,Hoang Van Hoa,Nguyen Ngoc Trang,Le Thi Thuy Lien,Pham Minh Thong,Vu Dang Luu 아시아심장혈관영상의학회 2022 Cardiovascular Imaging Asia Vol.6 No.2
Left pulmonary artery sling (LPAS) is a rare congenital anomaly in which the left pulmonary artery (LPA) originates from the posterior aspect of the right pulmonary artery and courses between the trachea and esophagus to reach the left lung. This anomaly causes distal tracheal and/or right main stem bronchus compression. Most LPAS cases are associated with early symptom onset, around 2 month-old, and have severe respiratory distress within the first year of life. There are two major types of LPAS based on the location of LPA and abnormal bronchial branching. The diagnosis can be made by using various imaging modalities. Herein, we present the imaging characteristics on multidetector computed tomography of 5 LPAS cases with respiratory distress (2 months to 12 months).
Sulforaphane Inhibits ICAM-1 Expression and Monocyte Adhesion in Human Bladder Cancer T24 Cells
Kyu Youn Ahn,Pham Ngoc Khoi,Young Suk Cho,Shinan Li,Dhiraj Kumar Sah,Yong Xia,Young Do Jung 대한체질인류학회 2021 해부·생물인류학 (Anat Biol Anthropol) Vol.34 No.1
Intracellular adhesion molecule-1 (ICAM-1) belongs to the immunoglobulin-like superfamily of adhesion molecules that mediate cell adhesion to other cells, and ICAM-1 is involved in cancer progression and recurrence. Since the ICAM-1 is considered as one of the therapeutic target against bladder cancer, we examined whether sulforaphane, an aliphatic isothiocyanate, could inhibit ICAM-1 expression in bladder cancer T24 cells. Sulforaphane inhibited phorbol 12-myristate 13-acetate (PMA)-induced ICAM-1 expression at the mRNA and protein levels in human bladder cancer cells, as revealed by reverse transcriptase polymerase chain reaction and western blot analyses, respectively. Specific inhibitor studies have shown that the transcription factors, activator protein-1 (AP-1) and nuclear factor-kappa B (NF-κB), are involved in PMA-induced ICAM-1 expression. We found that sulforaphane inhibited the activation of both AP-1 and NF-κB induced by PMA in bladder cancer cells. Interestingly, we also found that sulforaphane abrogated PMA-induced THP-1 monocyte adhesion to bladder cancer cells. Collectively, our results provide experimental evidence that sulforaphane could serve as a new therapeutic candidate against bladder cancer.
Bui Hung Thang,Pham Van Trinh,Le Dinh Quang,Nguyen Thi Huong,Phan Hong Khoi,Phan Ngoc Minh 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.3
Carbon nanotubes (CNTs) are some of the most valuable materials with high thermal conductivity. The thermal conductivity of individual multiwalled carbon nanotubes (MWCNTs) grown byusing chemical vapor deposition is 600 ± 100 Wm−1K−1 compared with the thermal conductivity419 Wm−1K−1 of Ag. Carbon-nanotube-based liquids – a new class of nanomaterials, have shownmany interesting properties and distinctive features offering potential in heat dissipation applicationsfor electronic devices, such as computer microprocessor, high power LED, etc. In this work,a multiwalled carbon-nanotube-based liquid was made of well-dispersed hydroxyl-functional multiwalledcarbon nanotubes (MWCNT-OH) in ethylene glycol (EG)/distilled water (DW) solutionsby using Tween-80 surfactant and an ultrasonication method. The concentration of MWCNT-OHin EG/DW solutions ranged from 0.1 to 1.2 gram/liter. The dispersion of the MWCNT-OH-basedEG/DW solutions was evaluated by using a Zeta-Sizer analyzer. The MWCNT-OH-based EG/DWsolutions were used as coolants in the liquid cooling system for the Intel Core i5 processor. Thethermal dissipation efficiency and the thermal response of the system were evaluated by directlymeasuring the temperature of the micro-processor using the Core Temp software and the temperaturesensors built inside the micro-processor. The results confirmed the advantages of CNTs inthermal dissipation systems for computer processors and other high-power electronic devices.
EGCG inhibits recepteur d’origine nantais expression by suppressing Egr-1 in gastric cancer cells
PARK, JUNG SUN,KHOI, PHAM NGOC,JOO, YOUNG EUN,LEE, YOUNG HAN,LANG, SVEN A.,STOELTZING, OLIVER,JUNG, YOUNG DO Spandidos Publications 2013 International journal of oncology Vol.42 No.3
<P>Abnormal accumulation and activation of the recepteur d'origine nantais (RON) has been implicated in epithelial tumor carcinogenesis. In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), the major green tea catechin, on the induction of RON and tumor growth in human gastric cancer. EGCG inhibited phorbol 12-myristate 13-acetate (PMA)-induced RON expression and reduced RON transcriptional activity. However, (-)-epigalloca-techin (EGC), (-)-epicatechin gallate (ECG) and (-)?epicatechin (EC) did not affect RON expression. Experiments with deleted and site-directed mutagenesis of the RON promoter indicated that Egr-1 binding sites in the RON promoter may be the EGCG?response element acting as a cis-element in gastric cancer cells. EGCG also inhibited PMA-induced Egr-1 expression and DNA binding in a dose-dependent manner. Furthermore, gastric cancer cells pretreated with PMA showed markedly enhanced invasiveness, which was partially abrogated by EGCG and siRNA-targeted RON and Egr-1. EGCG significantly reduced tumor growth in an in vivo tumor model, whereas RON expression was downregulated. These results suggest that EGCG may exert at least part of its anticancer effect by controlling RON expression through suppression of Egr-1 activation.</P>
XIA, YONG,LIAN, SEN,KHOI, PHAM NGOC,YOON, HYUN JOONG,HAN, JAE YOUNG,CHAY, KEE OH,KIM, KYUNG KEUN,JUNG, YOUNG DO Spandidos Publications 2015 International journal of oncology Vol.46 No.4
<P>Cell invasion is one of crucial reasons for cancer metastasis and malignancy. Recepteur d'origine Nantais (RON) has been reported to play an important role in the cancer cell invasion process. High accumulation and activation of RON has been implicated in gastric adenocarcinoma AGS cells. Chrysin is a naturally occurring phytochemical, a type of flavonoid, which has been reported to suppress tumor metastasis. However, the effects of chrysin on RON expression in gastric cancer are not well studied. In the present study, we examined whether chrysin affects RON expression in gastric cancer, and if so, its underlying mechanism. We examined the effect of chrysin on RON expression and activity, via RT-PCR, promoter study, and western blotting in human gastric cancer AGS cells. Chrysin significantly inhibited endogenous and inducible RON expression in a dose-dependent manner. After demonstrating that Egr-1 and NF-kappa B are the critically required transcription factors for RON expression, we discovered that chrysin suppressed Egr-1 and NF-K13 transcription factor activities. Additionally, the phorbol-12-myristate-13-acetate(PMA) induced cell invasion was partially abrogated by chrysin and an RON antibody. Our results suggest that chrysin has anticancer effects at least by suppressing RON expression through blocking Egr-1 and NF-kappa B in gastric cancer AGS cells.</P>
Helicobacter pylori and interleukin-8 in gastric cancer.
Lee, Ko Eun,Khoi, Pham Ngoc,Xia, Yong,Park, Jung Sun,Joo, Young Eun,Kim, Kyung Keun,Choi, Seok Yong,Jung, Young Do WJG Press 2013 World journal of gastroenterology Vol.19 No.45
<P>Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H. pylori infection and both cancer development and progression. Interleukin-8 (IL-8) is overexpressed in gastric mucosa exposed to H. pylori. The expression of IL-8 directly correlates with a poor prognosis in gastric cancer. IL-8 is multifunctional. In addition to its potent chemotactic activity, it can induce proliferation and migration of cancer cells. In this review, we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer. The relationship between IL-8 and H. pylori is discussed. We also summarize the current therapeutics against IL-8 in gastric cancer.</P>
Le Thi Thuy Lien,Nguyen Khoi Viet,Hoang Van Hoa,Phung Bao Ngoc,Nguyen Ngoc Trang,Vu Thi Kim Thoa,Nguyen Cong Tien,Phan Anh Phuong,Pham Minh Thong,Vu Dang Luu 아시아심장혈관영상의학회 2022 Cardiovascular Imaging Asia Vol.6 No.2
Objective: To compare left ventricular (LV) function, ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and regional wall motion analyzed in 256-slice dualsource coronary CT angiography (DSCT) with 2D transthoracic echocardiography (TTE). Materials and Methods: One hundred twelve patients suspected of coronary artery disease underwent DSCT and 2D-TTE within one week for LVEF, EDV, and ESV. The correlation between DSCT and 2D-TTE measurements was analyzed through linear regression and Bland- Altman analysis. Regional wall motion was visually scored with a 3-point scale (1, normal; 2, hypokinesia; 3, dysphagia, akinesia). Results: Average LVEF at 66.45%±1.27% (range 23%–85%) as determined on DSCT compared with 66.09%±1.01% (range 25%–84%) on 2D-TTE. LVEF exhibited a good correlation between DSCT and 2D-TTE (r=0.715; p<0.001). Good correlations between DSCT and 2D-TTE were demonstrated for LVEDV (r=0.732; p<0.001) and LVESV (r=0.841; p<0.001). Mean differences (±SD) of 1.78±24.10 mL (p<0.05) and 0.77±13.70 mL (p<0.05) were observed between DSCT and 2D-TTE for LVEDV and LVESV, respectively. LVEF was slightly overestimated with DSCT (0.52%±9.59%; p<0.05). Although the LVEF values calculated by DSCT and 2D-TTE were similar, EDV and ESV from DSCT were statistically higher than those from 2D-TTE (p<0.05). Agreement between DSCT and 2D-TTE in regional wall motion was 96.4%, κ=0.840. Conclusion: DSCT can provide comparable results to those using 2D-TTE for LV function (EF, EDV, and ESV) and regional wall motion assessment in a heterogeneous population.