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- 저자 : Pervaiz A Dar (검색결과 3 건)
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Bacterial ghosts as adjuvants: mechanisms and potential
Hajam, Irshad A.,Dar, Pervaiz A.,Won, Gayeon,Lee, John Hwa BioMed Central 2017 VETERINARY RESEARCH Vol.48 No.-
<P>Bacterial ghosts (BG) are empty cell envelopes derived from Gram-negative bacteria. They contain many innate immunostimulatory agonists, and are potent activators of a broad range of cell types involved in innate and adaptive immunity. Several considerable studies have demonstrated the effectiveness of BG as adjuvants as well as their ability to induce proinflammatory cytokine production by a range of immune and non-immune cell types. These proinflammatory cytokines trigger a generalized recruitment of T and B lymphocytes to lymph nodes that maximize the chances of encounter with their cognate antigen, and subsequent elicitation of potent immune responses. The plasticity of BG has allowed for the generation of envelope-bound foreign antigens in immunologically active forms that have proven to be effective vaccines in animal models. Besides their adjuvant property, BG also effectively deliver DNA-encoded antigens to dendritic cells, thereby leading to high transfection efficiencies, which subsequently result in higher gene expressions and improved immunogenicity of DNA-based vaccines. In this review, we summarize our understanding of BG interactions with the host immune system, their exploitation as an adjuvant and a delivery system, and address important areas of future research interest.</P>
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Bacterial flagellin—a potent immunomodulatory agent
Hajam, Irshad A,Dar, Pervaiz A,Shahnawaz, Imam,Jaume, Juan Carlos,Lee, John Hwa Nature Publishing Group 2017 Experimental and molecular medicine Vol.49 No.9
<P>Flagellin is a subunit protein of the flagellum, a whip-like appendage that enables bacterial motility. Traditionally, flagellin was viewed as a virulence factor that contributes to the adhesion and invasion of host cells, but now it has emerged as a potent immune activator, shaping both the innate and adaptive arms of immunity during microbial infections. In this review, we summarize our understanding of bacterial flagellin and host immune system interactions and the role flagellin as an adjuvant, anti-tumor and radioprotective agent, and we address important areas of future research interests.</P>
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Bacterial flagellin—a potent immunomodulatory agent
HAJAM IRSHAD AHMED,Pervaiz A Dar,Imam Shahnawaz,Juan Carlos Jaume,이존화 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Flagellin is a subunit protein of the flagellum, a whip-like appendage that enables bacterial motility. Traditionally, flagellin was viewed as a virulence factor that contributes to the adhesion and invasion of host cells, but now it has emerged as a potent immune activator, shaping both the innate and adaptive arms of immunity during microbial infections. In this review, we summarize our understanding of bacterial flagellin and host immune system interactions and the role flagellin as an adjuvant, anti-tumor and radioprotective agent, and we address important areas of future research interests.
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