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- 저자 : Penghua Li (검색결과 5 건)
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Yaru Li,Shuchen Zhang,Ziwei Zhu,Ruonan Zhou,Pingyuan Xu,Lingyan Zhou,Yue Kan,Jiao Li,Juan Zhao,Penghua Fang,Xizhong Yu,Wenbin Shang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4
Background: Ginsenoside Rb1 (GRb1) is capable of regulating lipid and glucose metabolism through itsaction on adipocytes. However, the beneficial role of GRb1-induced up-regulation of adiponectin in liversteatosis remains unelucidated. Thus, we tested whether GRb1 ameliorates liver steatosis and insulinresistance by promoting the expression of adiponectin. Methods: 3T3-L1 adipocytes and hepatocytes were used to investigate GRb1's action on adiponectinexpression and triglyceride (TG) accumulation. Wild type (WT) mice and adiponectin knockout (KO)mice fed high fat diet were treated with GRb1 for 2 weeks. Hepatic fat accumulation and function as wellas insulin sensitivity was measured. The activation of AMPK was also detected in the liver andhepatocytes. Results: GRb1 reversed the reduction of adiponectin secretion in adipocytes. The conditioned medium(CM) from adipocytes treated with GRb1 reduced TG accumulation in hepatocytes, which was partlyattenuated by the adiponectin antibody. In the KO mice, the GRb1-induced significant decrease of TGcontent, ALT and AST was blocked by the deletion of adiponectin. The elevations of GRb1-induced insulinsensitivity indicated by OGTT, ITT and HOMA-IR were also weakened in the KO mice. The CM treatmentsignificantly enhanced the phosphorylation of AMPK in hepatocytes, but not GRb1 treatment. Likewise,the phosphorylation of AMPK in liver of the WT mice was increased by GRb1, but not in the KO mice. Conclusions: The up-regulation of adiponectin by GRb1 contributes to the amelioration of liver steatosisand insulin resistance, which further elucidates a new mechanism underlying the beneficial effects ofGRb1 on obesity
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Rui Li,Xinyan Li,Hao Wang,Xianlun Tang,Penghua Li,Mengjie Shou 한국정보처리학회 2022 Journal of information processing systems Vol.18 No.5
A composite bionic soft gripper integrated with electromagnets and magneto-active elastomers is designed bycombining the structure of the human hand and the snake’s behavior of enhancing friction by actively adjustingthe scales. A silicon-based polymer containing magnetized hard magnetic particles is proposed as a soft finger,and it can be reversibly bent by adjusting the magnetic field. Experiments show that the length, width, andheight of rectangular soft fingers and the volume ratio of neodymium–iron–boron have different effects onbending angle. The flexible fingers with 20 vol% are the most efficient, which can bend to 90° when themagnetic field is 22 mT. The flexible gripper with four fingers can pick up 10.51 g of objects at the magneticfield of 105 mT. In addition, this composite bionic soft gripper has excellent magnetron performance, and itcan change surface like snakes and operate like human hands. This research may help develop soft devices formagnetic field control and try to provide new solutions for soft grasping.
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Honglei Zhang,Longzhu Li,Changhai Liu,Wenchang Wang,Penghua Liang,Naotoshi Mitsuzak,Zhidong Chen 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.3
This work provides a facile anodic electrodeposition method for synthesizing carbon coated α-Fe2O3 photoanode followedby annealing treatment with argon atmosphere. Compared with bare hematite photoanode, the carbon coated α-Fe2O3 photoanodesannealed at lower temperature (Fe2O3/C-L) and higher temperature (Fe2O3/C-H) have higher photocurrent densityas 0.3 and 0.5 mA cm−2 (at 1.23 V vs. RHE), respectively. The excellent PEC performance is attributed to the synergisticreaction of carbon and vacancy oxygen. The morphology and properties of the sample were characterized with scanningelectron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, UV–Vis spectra, X-raydiffractometry, X-ray photoelectron spectra, and photoelectrical measurements.
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An Improved Consistent Subspace Identification Method Using Parity Space for State-space Models
Jie Hou,Fengwei Chen,Penghua Li,Zhiqin Zhu,Fei Liu 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.5
In this paper, an alternative consistent subspace identification method using parity space is proposed. The future/past input data and the past output data are used to construct the instrument variable to eliminate thenoise effect on consistent estimation. The extended observability matrix and the triangular block-Toeplitz matrixare then retrieved from a parity space of the noise-free matrix using a singular value decomposition based method. The system matrices are finally estimated from the above estimated matrices. The consistency of the proposedmethod for estimation of the extended observability matrix and the triangular block-Toeplitz matrix is established. Compared with the classical SIMs using parity space like SIMPCA and SIMPCA-Wc, the proposed method generallyenhances the estimated model efficiency/accuracy thanks to the use of future input data. Two examples arepresented to illustrate the effectiveness and merit of the proposed method.
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( Xi Lin ),( Sha Liu ),( Guangrong Xie ),( Jing Chen ),( Penghua Li ),( Jianhua Chen ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.11
Wild strain L-6 was subjected to combined mutagenesis, including UV irradiation, atmospheric and room temperature plasma, and ion beam implantation, to increase the yield of 1,3-dihydroxyacetone (DHA). With application of a high-throughput screening method, mutant Gluconobacter oxydans I-2-239 with a DHA productivity of 103.5 g/l in flask-shake fermentation was finally obtained with the starting glycerol concentration of 120 g/l, which was 115.7% higher than the wild strain. The cultivation time also decreased from 54 h to 36 h. Compared with the wild strain, a dramatic increase in enzyme activity was observed for the mutant strain, although the increase in biomass was limited. DNA and amino acid sequence alignment revealed 11 nucleotide substitutions and 10 amino acid substitutions between the sldAB of strains L-6 and I-2-239. Simulation of the 3-D structure and prediction of active site residues and PQQ binding site residues suggested that these mutations were mainly related to PQQ binding, which was speculated to be favorable for the catalyzing capacity of glycerol dehydrogenase. RT-qPCR assay indicated that the transcription levels of sldA and sldB in the mutant strain were respectively 4.8-fold and 5.4-fold higher than that in the wild strain, suggesting another possible reason for the increased DHA productivity of the mutant strain.
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